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Biophysical Modeling of a Drosophila Photoreceptor

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Neural Information Processing (ICONIP 2009)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 5863))

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Abstract

It remains unclear how visual information is co-processed by different layers of neurons in the retina. In particular, relatively little is known how retina translates vast environmental light changes into neural responses of limited range. We began examining this question in a bottom-up way in a relatively simple fly eye. To gain understanding of how complex bio-molecular interactions govern the conversion of light input into voltage output (phototransduction), we are building a biophysical model of the Drosophila R1-R6 photoreceptor. Our model, which relates molecular dynamics of the underlying biochemical reactions to external light input, attempts to capture the molecular dynamics of phototransduction gain control in a quantitative way.

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References

  1. Hardie, R.C.: Voltage-sensitive potassium channels in Drosophila photoreceptors. Journal of Neuroscience 11, 3079–3095 (1991)

    Google Scholar 

  2. Hardie, R.C.: Whole-cell recordings of the light induced current in dissociated Drosophila photoreceptors: Evidence for feedback by calcium permeating the light-sensitive channels. Proceedings: Biological Sciences 245, 203–210 (1991)

    Article  Google Scholar 

  3. Hardie, R.C., Postma, M.: Phototransduction in microvillar photoreceptors of Drosophila and other invertebrates. The Senses: A Comprehensive Reference 1, 77–130 (2008)

    Article  Google Scholar 

  4. Hochstrate, P., Hamdorf, K.: Microvillar components of light adaptation in blowflies. Journal of General Physiology 95, 891–910 (1990)

    Article  Google Scholar 

  5. Juusola, M., Hardie, R.C.: Light adaptation in drosophila photoreceptors: I. response dynamics and signaling efficiency at 25 °c. Journal of General Physiology 117, 3–25 (2001)

    Article  Google Scholar 

  6. Krause, Y., Krause, S., Huang, J., Liu, C.-H., Hardie, R.C., WeckstrÅ‘m, M.: Light-dependent modulation of shab channels via phosphoinositide depletion in Drosophila photoreceptors. Neuron. 59, 596–607 (2008)

    Article  Google Scholar 

  7. Liu, C.H., Satoh, A.K., Postma, M., Huang, J., Ready, D.F., Hardie, R.C.: ca 2 +  dependent metarhodopsin inactivation mediated by calmodulin and ninac myosin iii. Neuron. 59, 778–789 (2008)

    Article  Google Scholar 

  8. Luo, C.H., Rudy, Y.: A dynamic model of the cardiac ventricular action potential: I. simulations of ionic currents and concentration changes. Circulation Research 74, 1071–1096 (1994)

    Google Scholar 

  9. Mullins, L.J.: A mechanism for na  + /ca 2 +  transport. Journal of General Physiology 70, 681–695 (1977)

    Article  Google Scholar 

  10. J.E. Niven, M. VaÌ‹haÌ‹sÅ‘yrinki, M. Kauranen, R.C. Hardie, M. Juusola, and M. WeckstrÅ‘m. The contribution of shaker k  +  channels to the information capacity of Drosophila photoreceptors. Nature 6923, 630–634 (2003)

    Article  Google Scholar 

  11. Oberwinkler, J.C.: Calcium influx, diffusion and extrusion in fly photoreceptor cells. PhD thesis, University of Groningen (2000)

    Google Scholar 

  12. Oberwinkler, J.C., Stavenga, D.G.: Light dependence of calcium and membrane potential measured in blowfly photoreceptors in vivo. Journal of General Physiology 112, 113–124 (1998)

    Article  Google Scholar 

  13. Peretz, A., Abitbol, I., Sobko, A., Wu, C.F., Attali, B.: A ca 2 + /calmodulin-dependent protein kinase modulates Drosophila photoreceptor k  +  currents: A role in shaping the photoreceptor potential. Journal of Neuroscience 18, 9153–9162 (1998)

    Google Scholar 

  14. Postma, M., Oberwinkler, J.C., Stavenga, D.G.: Does ca 2 +  reach millimolar concentrations after single photon absorption in Drosophila photoreceptor microvilli? Biophys. J. 77, 1811–1823 (1999)

    Article  Google Scholar 

  15. Pumir, A., Graves, J., Ranganathan, R., Shraiman, B.I.: Systems analysis of the single photon response in invertebrate photoreceptors. Proc. Natl. Acad. Sci. U.S.A 105, 10354–10359 (2008)

    Article  Google Scholar 

  16. Rasmusson, R.L., Clark, J.W., Giles, W.R., Robinson, K., Clark, R.B., Shibata, E.F., Campbell, D.L.: A mathematical model of electrophysiological activity in a bullfrog atrial cell. American Journal of Physiology - Heart and Circulatory Physiology 259, 370–389 (1990)

    Google Scholar 

  17. van Hateren, J.H., Snippe, H.P.: Phototransduction in primate cones and blowfly photoreceptors: Different mechanisms, different algorithms, similar response. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 192, 187–197 (2006)

    Article  Google Scholar 

  18. Wolff, T., Ready, D.F.: The Development of Drosophila melanogaster. Cold Spring Harbor Laboratory Press, Plainview (1993)

    Google Scholar 

  19. Wong, F., Knight, B.W., Dodge, F.A.: Dispersion of latencies in photoreceptors of limulus and the adapting-bump model. Jounal of General Physiology 76, 517–537 (1980)

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Automatic Control and Systems Engineering, University of Sheffield, Mappin Street, Sheffield, S1 3JD, UK

    Zhuoyi Song, Daniel Coca & Stephen Billings

  2. Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN, Sheffield, UK

    Zhuoyi Song & Mikko Juusola

  3. Department of Physiology, Development and Neuroscience, Cambridge University, Downing Street, Cambridge, CB2 3DY, UK

    Marten Postma & Roger C. Hardie

Authors
  1. Zhuoyi Song
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  2. Daniel Coca
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  3. Stephen Billings
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  4. Marten Postma
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  5. Roger C. Hardie
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  6. Mikko Juusola
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Editor information

Editors and Affiliations

  1. Department of Electronic Engineering, City University of Hong Kong, Hong Kong,  

    Chi Sing Leung

  2. School of Electrical Engineering and Computer Science, Kyungpook National University, 1370 Sankyuk-Dong, Puk-Gu, 702-701, Taegu, Korea

    Minho Lee

  3. School of Information Technology, King Mongkut’s University of Technology Thonburi, 126 Pracha-U-Thit Rd., Bangmod, Thungkru, 10140, Bangkok, Thailand

    Jonathan H. Chan

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© 2009 Springer-Verlag Berlin Heidelberg

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Song, Z., Coca, D., Billings, S., Postma, M., Hardie, R.C., Juusola, M. (2009). Biophysical Modeling of a Drosophila Photoreceptor. In: Leung, C.S., Lee, M., Chan, J.H. (eds) Neural Information Processing. ICONIP 2009. Lecture Notes in Computer Science, vol 5863. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-10677-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-10677-4_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-10676-7

  • Online ISBN: 978-3-642-10677-4

  • eBook Packages: Computer ScienceComputer Science (R0)

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