Abstract
Digital breast tomosynthesis (DBT) provides a possible solution to overcome the problem of overlapping tissue since it provides a 3D volume representation of the imaged object. In order to study the detectability of lesions in DBT, we have developed a simulation tool where objects are simulated into real projection DBT images. The methodology has already been validated for 3D geometrical shapes and has now been extended to irregularly shaped lesions. The work focuses on the simulation of clusters of microcalcifications that are modeled using micro-CT images of biopsy specimens containing such lesions. The compilation of a database of microcalcifications clusters classified following Le Gal nomenclature is ongoing. These extracted model lesions were then simulated into images of biopsy specimens next to the original real cluster in order to confirm the realism of the simulation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Dobbins III, J.T.: Tomosynthesis imaging: At a translational crossroads. Med. Phys. 36(6), 1956–1967 (2009)
Wu, T., Stewart, A., Stanton, M., McCauley, T., Phillips, W., Kopans, D.B., Moore, R.H., Eberhard, J.W., Opsahl-Ong, B., Niklason, L., Williams, M.B.: Tomographic mammography using a limited number of lowdose cone-beam projection images. Med. Phys. 30, 365–380 (2003)
Shaheen, E., Zanca, F., Sisini, F., Zhang, G., Jacobs, J., Bosmans, H.: Simulation of 3D objects into breast tomosynthesis images. Radiat. Prot. Dosimet. 10 (2010)
Zanca, F., Chakraborty, D.P., Van Ongeval, C., Jacobs, J., Claus, F., Marchal, G., Bosmans, H.: An improved method for simulating microcalcifications in digital mammograms. Med. Phys. 35, 4012–4018 (2008)
Ruschin, M., et al.: Improved in-plane visibility of tumors using breast tomosynthesis. In: Proc. of SPIE, vol. 6510, pp. 65101J1– 65101J11 (2007)
Siddon, R.L.: Fast calculation of the exact radiological path for a three-dimensional CT array. Med. Phys. 12, 252–255 (1985)
Boone, J.M., Lindfors, K.K., Cooper III, V.N., Seibert, J.A.: Scatter/primary in mammography: Comprehensive results. Med. Phys. 27, 2408–2416 (2000)
Fandos-Morera, A., Prats-Esteve, M., Tura-Soteras, J.M., Traveria-Cros, A.: Breast Tumors: Composition of Microcalcifications. Radiology 169, 325–327 (1988)
Le Gal, M., et al.: Diagnostic value of clustered microcalcifications discovered by mammography. Bull. Cancer (Paris) 71, 57–64 (1984)
Mertelmeier, T., Orman, J., Haerer, W., Dudam, M.K.: Optimizing filtered backprojection reconstruction for a breast tomosynthesis prototype device. In: Proc. of SPIE, vol. 6142, pp. 61420F1– 61420F12 (2006)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Shaheen, E. et al. (2010). Realistic Simulation of Microcalcifications in Breast Tomosynthesis. In: MartÃ, J., Oliver, A., Freixenet, J., MartÃ, R. (eds) Digital Mammography. IWDM 2010. Lecture Notes in Computer Science, vol 6136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13666-5_32
Download citation
DOI: https://doi.org/10.1007/978-3-642-13666-5_32
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-13665-8
Online ISBN: 978-3-642-13666-5
eBook Packages: Computer ScienceComputer Science (R0)