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Comparison of Subregional Breast Density with Whole Breast Density

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Digital Mammography (IWDM 2010)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 6136))

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Abstract

The purpose of this paper is to compare subregional breast density and whole breast density and their association with breast cancer risk. The film mammograms of 278 cases and 834 age and ethnicity-matched controls were digitized and analyzed using single-energy x-ray absorptiometry (SXA). The subregion was a 3-cm diameter circle centered in the breast. The whole and subregional densities are found to be highly correlated (r2=0.7). The 4:1 quartile odds ratio after controlling for other significant risk factors (age, BMI, family history and age at first live birth) was 3.6 (95 CI 2.1-5.4) and the 2.4 (95 CI 1.5-3.7) for the whole and subregional breast density, respectively. Further studies are underway to optimize the placement of the ROI and combined multiple regions.

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Author information

Authors and Affiliations

  1. Department of Radiology and Bioimaging, University California at San Francisco, 1635 Divisadero Street, Suite 525, San Francisco, CA, 94115, USA

    Serghei Malkov, Jeff Wang & John Shepherd

  2. Departments of Medicine and Epidemiology and Biostatistics, University California at San Francisco, San Francisco, CA, USA

    Lin Ma, Karla Kerlikowske & Steve Cummings

  3. San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA

    Steve Cummings

Authors
  1. Serghei Malkov
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  2. Lin Ma
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  3. Karla Kerlikowske
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  4. Jeff Wang
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  5. Steve Cummings
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  6. John Shepherd
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Editor information

Editors and Affiliations

  1. Institute of Informatics and Applications, University of Girona, Girona, Catalonia, Spain

    Joan Martí

  2. Institute of Informatics and Applications, University of Girona, Campus Montilivi, Ed. P-IV, 17071, Girona, Spain

    Arnau Oliver

  3. Computer Vision and Robotics Group, University of Girona, Av. Lluís Santaló, 17071, Girona, Spain

    Jordi Freixenet  & Robert Martí  & 

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© 2010 Springer-Verlag Berlin Heidelberg

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Malkov, S., Ma, L., Kerlikowske, K., Wang, J., Cummings, S., Shepherd, J. (2010). Comparison of Subregional Breast Density with Whole Breast Density. In: Martí, J., Oliver, A., Freixenet, J., Martí, R. (eds) Digital Mammography. IWDM 2010. Lecture Notes in Computer Science, vol 6136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13666-5_54

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  • DOI: https://doi.org/10.1007/978-3-642-13666-5_54

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-13665-8

  • Online ISBN: 978-3-642-13666-5

  • eBook Packages: Computer ScienceComputer Science (R0)

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