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Scanner for Integrated X-Ray Breast Tomosynthesis and Molecular Breast Imaging Tomosynthesis

  • Conference paper
Digital Mammography (IWDM 2010)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 6136))

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Abstract

A dual modality tomosynthesis (DMT) breast scanner has been developed that combines x-ray breast tomosynthesis (XBT) and molecular breast imaging tomosynthesis (MBIT) on a common upright gantry to obtain co-registered structural and functional tomosynthesis images. This paper describes the scanner’s design and operation, and summarizes the results of a pilot clinical evaluation using the tracer 99mTc-sestamibi. The pilot study results suggest that DMT breast scanning is feasible and provides improved specificity and positive predictive value compared to XBT alone. Potential clinical roles for DMT scanning include problem solving for equivocal mammographic/ultrasound studies; as an aid in biopsy target selection following a positive mammogram with multiple suspicious areas; cancer surveillance in patients with a personal history of breast cancer; pre-surgical planning for determination of disease extent; as an alternative for women for whom MRI is impossible; and for monitoring response to neoadjuvant therapy.

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Author information

Authors and Affiliations

  1. Department of Radiology, University of Virginia, Charlottesville, VA, USA

    Mark B. Williams, Patricia G. Judy, Zongyi Gong & Audrey E. Graham

  2. Department of Radiology, West Virginia University, Morgantown, WV, USA

    Stan Majewski

  3. Dexela, Ltd., London, UK

    Spencer Gunn

Authors
  1. Mark B. Williams
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  2. Patricia G. Judy
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  3. Zongyi Gong
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  4. Audrey E. Graham
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  5. Stan Majewski
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  6. Spencer Gunn
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Editor information

Editors and Affiliations

  1. Institute of Informatics and Applications, University of Girona, Girona, Catalonia, Spain

    Joan Martí

  2. Institute of Informatics and Applications, University of Girona, Campus Montilivi, Ed. P-IV, 17071, Girona, Spain

    Arnau Oliver

  3. Computer Vision and Robotics Group, University of Girona, Av. Lluís Santaló, 17071, Girona, Spain

    Jordi Freixenet  & Robert Martí  & 

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© 2010 Springer-Verlag Berlin Heidelberg

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Williams, M.B., Judy, P.G., Gong, Z., Graham, A.E., Majewski, S., Gunn, S. (2010). Scanner for Integrated X-Ray Breast Tomosynthesis and Molecular Breast Imaging Tomosynthesis. In: Martí, J., Oliver, A., Freixenet, J., Martí, R. (eds) Digital Mammography. IWDM 2010. Lecture Notes in Computer Science, vol 6136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13666-5_60

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  • DOI: https://doi.org/10.1007/978-3-642-13666-5_60

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-13665-8

  • Online ISBN: 978-3-642-13666-5

  • eBook Packages: Computer ScienceComputer Science (R0)

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