Abstract
Surface-based morphometry (SBM) is widely used in biomedical imaging and other domains to localize shape changes related to different conditions. This paper presents a computational framework that integrates a set of effective surface registration and analysis methods to form a unified SBM processing pipeline. Surface registration includes two parts: surface alignment in the object space by employing the iterative closest point (ICP) method, and surface alignment in the parameter space by using conformal mapping and landmark-based thin-plate spline methods. Statistical group analysis of registered surface data is then conducted by surface-based general linear model and random field theory addressing multiple testing issues. The effectiveness of the proposed framework is demonstrated by applying it to a fetal alcohol syndrome (FAS) study for identifying facial dysmorphology in FAS patients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Besl, P.J., McKay, N.D.: A method for registration of 3-d shapes. IEEE Trans. on Pattern Analysis and Machine Intelligence 14(2), 239–256 (1992)
Bookstein, F.L.: Shape and the information in medical images: a decade of the morphometric synthesis. Comput. Vis. Image Underst. 66(2), 97–118 (1997)
Bronstein, A.M., Bronstein, M.M., Kimmel, R.: Calculus of nonrigid surfaces for geometry and texture manipulation. IEEE Trans. on Visualization and Computer Graphics 13(5), 902–913 (2007)
do Carmo, M.P.: Differential geometry of curves and surfaces. Prentice Hall, Englewood Cliffs (1976)
Eck, M., DeRose, T.D., Duchamp, T., et al.: Multiresolution analysis of arbitrary meshes. In: Proc. of ACM SIGGRAPH 1995, pp. 173–182 (1995)
Fang, S., McLaughlin, J., et al.: Automated diagnosis of fetal alcohol syndrome using 3D facial image analysis. In: Orthodontics & Craniofacial Res., pp. 162–171 (2008)
Floater, M.S., Hormann, K.: Surface parameterization: a tutorial and survey. In: Advances in Multiresolution for Geometric Modelling, pp. 157–186. Springer, Heidelberg (2005)
Gu, X., Wang, Y., et al.: Genus zero surface conformal mapping and its application to brain surface mapping. IEEE Trans. on Medical Imaging 23(8), 949–958 (2004)
Hammond, P., Hutton, T.J., Allanson, J.E., et al.: 3D analysis of facial morphology. American Journal of Medical Genetics 126A, 339–348 (2004)
Hoyme, H., May, P., Kalberg, W., et al.: A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: Clarification of the 1996 institute of medicine criteria. Pediatrics, 39–47 (2005)
Jones, K.L., Robinson, L.K., Bakhireva, L.N., et al.: Accuracy of the diagnosis of physical features of fetal alcohol syndrome by pediatricians after specialized training. Pediatrics 118, 1734–1738 (2006)
Jones, K.L., Smith, D.W.: Recognition of the fetal alcohol syndrome in early infancy. Lancet 2, 999–1001 (1973)
Moore, E.S., Ward, R.E., Wetherill, L.F., et al.: Unique facial features distinguish fetal alcohol syndrome patients and controls in diverse ethnic populations. Alcoholism: Clinical and Experimental Research 31, 1707–1713 (2007)
Peyre, G.: Toobox_Graph, http://www.ceremade.dauphine.fr/~peyre/matlab/graph/content.html
Sheffer, A., Praun, E., Rose, K.: Mesh parameterization methods and their applications. Found. Trends. Comput. Graph. Vis. 2(2), 105–171 (2006)
Shen, L., Farid, H., McPeek, M.A.: Modeling 3-dimensional morphological structures using spherical harmonics. Evolution 63(4), 1003–1016 (2009)
Shen, L., Saykin, A., Chung, M.K., et al.: Morphometric analysis of hippocampal shape in mild cognitive impairment: an imaging genetics study. In: IEEE 7th Int. Sym. on Bioinformatics and BioEngineering, Boston, MA, pp. 211–217 (2007)
Stoler, J.M., Holmes, L.B.: Recognition of facial features of fetal alcohol syndrome in the newborn. American Journal of Medical Genetics Part C 127(1), 21–27 (2004)
Tutte, W.T.: How to draw a graph. London Mathematical Soc. 13, 743–768 (1963)
Wan, J., Shen, L., Sheehan, K.E., et al.: Shape analysis of thalamic atrophy in multiple sclerosis. In: MIAMS, pp. 93–104. Imperial College, London (2009)
Wang, Y., Gupta, M., et al.: High resolution tracking of non-rigid 3d motion of densely sampled data using harmonic maps. In: Int. Conf. on Computer Vision (2005)
Worsley, K.J., Andermann, M., Koulis, M., et al.: Detecting changes in non-isotropic images. Human Brain Mapping 8, 98–101 (1999)
Author information
Authors and Affiliations
Consortia
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Wan, J. et al. (2010). A Framework for 3D Analysis of Facial Morphology in Fetal Alcohol Syndrome. In: Liao, H., Edwards, P.J."., Pan, X., Fan, Y., Yang, GZ. (eds) Medical Imaging and Augmented Reality. MIAR 2010. Lecture Notes in Computer Science, vol 6326. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15699-1_13
Download citation
DOI: https://doi.org/10.1007/978-3-642-15699-1_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-15698-4
Online ISBN: 978-3-642-15699-1
eBook Packages: Computer ScienceComputer Science (R0)