Abstract
Intracellular transport involves the processive displacement of molecular motors on microtubules. These motors are specialized to walk in one or the other direction on the microtubule. It is not known yet how this bi-directional traffic is organized in order to be efficient. Here we use some modeling based on cellular automata models to point out the problems caused by bidirectional transport, we discuss the role of confinement around the microtubule, and we illustrate how the dynamics of the microtubules could help preventing jam formation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ebbinghaus, M., Appert-Rolland, C., Santen, L.: Bidirectional transport on dynamic networks (2010) (submitted), arXiv:0912.3658
Ebbinghaus, M., Santen, L.: A model for bidirectional traffic of cytoskeletal motors. J. Stat. Mech., P03030 (2009)
Klumpp, S., Lipowsky, R.: Phase transitions in systems with two species of molecular motors. Europhys. Lett. 66, 90–96 (2004)
Lipowsky, R., Klumpp, S., Nieuwenhuizen, T.M.: Random walks of cytoskeletal motors in open and closed compartments. Phys. Rev. Lett. 87, 108101 (2001)
Nishinari, K., Okada, Y., Schadschneider, A., Chowdhury, D.: Intracellular transport of single-headed molecular motors KIF1A. Phys. Rev. Lett. 95, 118101 (2005)
Parmeggiani, A., Franosch, T., Frey, E.: Phase coexistence in driven one dimensional transport. Phys. Rev. Lett. 90, 086601 (2003)
Shemesh, O.A., Erez, H., Ginzburg, I., Spira, M.E.: Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching. Traffic 9, 458–471 (2008)
Stokin, G.B., Lillo, C., Falzone, T.L., Brusch, R.G., Rockenstein, E., Mount, S.L., Raman, R., Davies, P., Masliah, E., Williams, D.S., Goldstein, L.S.B.: Axonopathy and transport deficits early in the pathogenesis of alzheimer’s disease. Science 307, 1282 (2005)
Tailleur, J., Evans, M., Kafri, Y.: Nonequilibrium phase transitions in the extraction of membrane tubes by molecular motors. Phys. Rev. Lett. 102, 118109 (2009)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ebbinghaus, M., Appert-Rolland, C., Santen, L. (2010). Bidirectional Traffic on Microtubules. In: Bandini, S., Manzoni, S., Umeo, H., Vizzari, G. (eds) Cellular Automata. ACRI 2010. Lecture Notes in Computer Science, vol 6350. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15979-4_58
Download citation
DOI: https://doi.org/10.1007/978-3-642-15979-4_58
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-15978-7
Online ISBN: 978-3-642-15979-4
eBook Packages: Computer ScienceComputer Science (R0)