Abstract
In current clinical settings, there are several technological challenges to perform automated functional analysis from cardiac MRI. In this work, we present a framework to automatically segment the heart anatomy, define segments of the left ventricle, and extract myocardial motions for quantitative analysis of cardiac global and regional functions. This framework makes use of the cardiac MRI sequences that are widely available in clinical practice, and improves the performance of the automated processing by combining information from multiple MRI sequences. We employed 20 pathological datasets to evaluate the proposed framework where the automatic analysis was compared with the manual intervention assisted analysis. The results showed high correlation between the two methods for the global function analysis (volume: \(R^2\!\!>\!\!0.8\), ejection fraction:\(R^2\!\!=\!\!0.88\)), and for the regional dyssynchrony analysis (wall motion: \(R^2\!\!=\!\!0.89\); thickening: \(R^2\!\!=\!\!0.81\)). We also found that the automated method could fully include apical and basal volume, resulting in consistent overestimation of the left ventricle volume (~40mL, \(P\!\!<\!\!0.05\)) and small underestimation of ejection fraction (− 0.024, \(P\!\!<\!\!0.001\)).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fact Sheet No. 317, World Health Organization: Cardiovascular diseases (February 2007)
Camara, O., Oubel, E., Piella, G., Balocco, S., De Craene, M., Frangi, A.: Multi-sequence Registration of Cine, Tagged and Delay-Enhancement MRI with Shift Correction and Steerable Pyramid-Based Detagging. In: Ayache, N., Delingette, H., Sermesant, M. (eds.) FIMH 2009. LNCS, vol. 5528, pp. 330–338. Springer, Heidelberg (2009)
Frangi, A.F., Niessen, W.J., Viergever, M.A.: Three-dimensional modeling for functional analysis of cardiac images: A review. IEEE Transactions on Medical Imaging 20, 2–5 (2001)
Uribe, S., Muthurangu, V., Boubertakh, R., Schaeffter, T., Razavi, R., Hill, D.L., Hansen, M.S.: Whole-heart cine MRI using real-time respiratory self-gating. Magnetic Resonance in Medicine 57(3), 606–613 (2007)
Nesser, H.J., Sugeng, L., Corsi, C., Weinert, L., Niel, J., Ebner, C., Steringer-Mascherbauer, R., Schmidt, F., Schummers, G., Lang, R.M., Mor-Avi, V.: Volumetric analysis of regional left ventricular function with real-time three-dimensional echocardiography: validation by magnetic resonance and clinical utility testing. Heart, 572–578 (2007)
Li, C., Carreras, F., Leta, R., Carballeira, L., Pujadas, S., Pons-Llado, G.: Mechanical left ventricular dyssynchrony detection by endocardium displacement analysis with 3d speckle tracking technology. The International Journal of Cardiovascular Imaging 26, 867–870 (2010)
Grevera, G.J., Udupa, J.K.: Shape-based interpolation of multidimensional grey-level images. IEEE Trans. Medical Imaging 15(6), 881–892 (1996)
Zhuang, X., Rhode, K., Arridge, S., Razavi, R., Hill, D., Hawkes, D., Ourselin, S.: An atlas-based segmentation propagation framework using locally affine registration – application to automatic whole heart segmentation. In: Metaxas, D., Axel, L., Fichtinger, G., Székely, G. (eds.) MICCAI 2008, Part II. LNCS, vol. 5242, pp. 425–433. Springer, Heidelberg (2008)
Zhuang, X., Rhode, K., Razavi, R., Hawkes, D.J., Ourselin, S.: A registration-based propagation framework for automatic whole heart segmentation of cardiac MRI. IEEE Transactions on Medical Imaging 29(9), 1612–1625 (2010)
Studholme, C., Hill, D.L.G., Hawkes, D.J.: An overlap invariant entropy measure of 3D medical image alignment. Pattern Recognition 32(1), 71–86 (1999)
Chandrashekara, R., Mohiaddin, R., Rueckert, D.: Analysis of 3-D myocardial motion in tagged MR images using nonrigid image registration. IEEE Transactions on Medical Imaging 23(10), 1245–1250 (2004)
Chen, T., Wang, X., Chung, S., Metaxas, D.N., Axel, L.: Automated 3d motion tracking using gabor filter bank, robust point matching, and deformable models. IEEE Trans. Med. Imaging 29(1), 1–11 (2010)
Zhang, S., Wang, X., Metaxas, D.N., Chen, T., Axel, L.: LV surface reconstruction from sparse TMRI using laplacian surface deformation and optimization. In: ISBI, pp. 698–701 (2009)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Zhuang, X. et al. (2011). A Framework Combining Multi-sequence MRI for Fully Automated Quantitative Analysis of Cardiac Global And Regional Functions. In: Metaxas, D.N., Axel, L. (eds) Functional Imaging and Modeling of the Heart. FIMH 2011. Lecture Notes in Computer Science, vol 6666. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21028-0_47
Download citation
DOI: https://doi.org/10.1007/978-3-642-21028-0_47
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-21027-3
Online ISBN: 978-3-642-21028-0
eBook Packages: Computer ScienceComputer Science (R0)