Skip to main content

Automatic Breast Cancer Diagnosis Based on K-Means Clustering and Adaptive Thresholding Hybrid Segmentation

  • Conference paper
Image Processing and Communications Challenges 3

Part of the book series: Advances in Intelligent and Soft Computing ((AINSC,volume 102))

Summary

The paper presents k-means based hybrid segmentation method for breast cancer diagnosis problem. It is part of the computer system to support diagnosis based on microscope images of the fine needle biopsy. The system assumes distinguishing malignant from benign cases. Described method is an alternative to the previously presented algorithms based on fuzzy c-means clustering and competitive neural networks. However, it uses similar idea of combining clustering in RGB space with adaptive thresholding. At first, thresholding reveals objects on background. Then image is clustered with k-means algorithm to distinguish nuclei from red blood cells and other objects. Correct segmentation is crucial to obtain good quality features measurements and consequently successful diagnosis. The system of malignancy classification was tested on a set of real case medical images with promising results.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Al-Kofahi, Y., Lassoued, W., Lee, W., Roysam, B.: Improved Automatic Detection and Segmentation of Cell Nuclei in Histopathology Images. IEEE Trans. on Biomedcial Engineering 57(4), 841–852 (2010)

    Article  Google Scholar 

  2. Breiman, L., Friedman, J., Stone, C.J., Olshen, R.A.: Classification and Regression Trees. Chapman & Hall, Boca Raton (1993)

    Google Scholar 

  3. Clocksin, W.F.: Automatic segmentation of overlapping nuclei with high background variation using robust estimation and flexible contour models. In: Proc 12th Int. Conf. Image Analysis and Processing, ICIAPŠ 2003, pp. 682–687 (2003)

    Google Scholar 

  4. Cloppet, F., Boucher, A.: Segmentation of overlapping/aggregating nuclei cells in biological images. In: Proc. 19th Int. Conf. on Pattern Recognition, ICPR 2003, pp. 1–4 (2008)

    Google Scholar 

  5. Filipczuk, P., Kowal, M., Marciniak, A.: Feature selection for breast cancer malignancy classification problem. J. Medical Informatics & Technologies 15, 193–199 (2010)

    Google Scholar 

  6. Gil, J., Wu, H., Wang, B.Y.: Image analysis and morphometry in the diagnosis of breast cancer. J. Microsc. Res. Tech. 59, 109–118 (2002)

    Article  Google Scholar 

  7. Gurcan, M.N., Boucheron, L.E., Can, A., Madabhushi, A., Rajpoot, N.M., Yener, B.: Histopathological Image Analysis: A Review. IEEE Reviews in Biomedical Engineering 2, 147–171 (2009)

    Article  Google Scholar 

  8. Gonzalez, R.C., Woods, R.E.: Digital Image Processing. Prentice Hall, New Jersey (2001)

    Google Scholar 

  9. Hrebień, M., Steć, P., Obuchowicz, A., Nieczkowski, T.: Segmentation of breast cancer fine needle biopsy cytological images. Int. J. Appl. Math and Comp. Sci. 18(2), 159–170 (2008)

    Article  Google Scholar 

  10. Jeleń, Ł., Fevens, T., Krzyżak, A.: Classification of breast cancer malignancy using cytological images of fine needle aspiration biopsies. Int. J. Appl. Math and Comp. Sci. 18(1), 75–83 (2008)

    Article  Google Scholar 

  11. Kanungo, T., Mount, D.M., Netanyahu, N.S., Piatko, C.D., Silverman, R., Wu, A.Y.: An efficient k-means clustering algorithm: Analysis and implementation. IEEE Trans. Pattern Analysis and Machine Intelligence 24, 881–892 (2002)

    Article  Google Scholar 

  12. Kowal, M., Korbicz, J.: Segmentation of breast cancer fine needle biopsy cytological images using fuzzy clustering. In: Koronacki, J., Raś, Z.W., Wierzchoń, S.T., Kacprzyk, J. (eds.) Advances in Machine Learning I. Studies in Computational Intelligence, vol. 262, pp. 405–417. Springer, Heidelberg (2010)

    Chapter  Google Scholar 

  13. Lloyd, S.P.: Least squares quantization in PCM. IEEE Trans. Information Theory 28(2), 129–137 (1982)

    Article  MathSciNet  MATH  Google Scholar 

  14. MacKay, D.: Information Theory, Inference and Learning Algorithms. Cambridge University Press, Cambridge (2003)

    MATH  Google Scholar 

  15. Marciniak, A., Obuchowicza, A., Monczak, R., Kołodziński, M.: Cytomorphometry of Fine Needle Biopsy Material from the Breast Cancer. In: Proc. 4th Int. Conf. on Computer Recognition Systems CORES 2005, pp. 603–609. Springer, Heidelberg (2005)

    Google Scholar 

  16. Mitchell, T.M.: Machine Learning. McGraw-Hill, New York (1997)

    MATH  Google Scholar 

  17. Obuchowicz, A., Hrebień, M., Nieczkowski, T., Marciniak, A.: Computational intelligence techniques in image segmentation for cytopathology. In: Smoliñski, T.G., Milanova, M.G., Hassanien, A.-G. (eds.) Computational Intelligence in Biomedicine and Bioinformatics: Current Trends and Applications, pp. 169–199. Springer, Heidelberg (2008)

    Chapter  Google Scholar 

  18. Otsu, N.: A threshold selection method from gray-level histograms. IEEE Trans. Sys. Man. and Cyber. (9), 62–66 (1979)

    Article  Google Scholar 

  19. Peng, Y., Park, M., Xu, M., Luo, S., Jin, J.S., Cui, Y., Wong, F.W.S., Santos, L.D.: Clustering nuclei using machine learning techniques. In: Proc. Int. IEEE/ICME Conf. on Complex Medical Engineering, pp. 52–57 (2010)

    Google Scholar 

  20. Sezgin, M., Sankur, B.: Survey over image thresholding techniques and quantitative performance evaluation. J. Electronic Imaging 13(1), 146–165 (2003)

    Article  Google Scholar 

  21. Shapiro, L.G., Stockman, G.C.: Computer Vision. Prentice Hall, New Jersey (2002)

    Google Scholar 

  22. Śmietanski, J., Tadeusiewicz, R., Łuczyńska, E.: Texture Analysis in Perfusion Images of Prostate Cancer - a Case Study. Int. J. Appl. Math and Comp. Sci. 20(1), 149–156 (2010)

    Article  Google Scholar 

  23. Suri, J.S., Setarhdan, K., Singh, S.: Advanced Algorithmic Approaches to Medical Image Segmentation. Springer, London (2002)

    Book  Google Scholar 

  24. Underwood, J.C.E.: Introduction to biopsy interpretation and surgical pathology. Springer, London (1987)

    Google Scholar 

  25. Wolberg, W.H., Street, W.N.: Mangasarian: Breast cytology diagnosis via digital image analysis. Analytical and Quantitative Cytology and Histology 15, 396–404 (1993)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Filipczuk, P., Kowal, M., Obuchowicz, A. (2011). Automatic Breast Cancer Diagnosis Based on K-Means Clustering and Adaptive Thresholding Hybrid Segmentation. In: Choraś, R.S. (eds) Image Processing and Communications Challenges 3. Advances in Intelligent and Soft Computing, vol 102. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23154-4_33

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-23154-4_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-23153-7

  • Online ISBN: 978-3-642-23154-4

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics