Abstract
Less than a half of hepatitis C patients respond to the current therapy by peg-interferon combined with ribavirin, and the genomic basis of those drug resistance remains unknown. It is recognized that the emerging challenge in the development of therapies for hepatitis C is new functions and mysteries of hepatitis C virus (HCV) non structural 5A (NS5A) protein. Different from current studies using small experimental samples to analyze relations between the HCV NS5A region and the response to interferon/ribavirin therapy, we introduce a data mining-based framework that exploits the largest available HCV database. This paper focuses on the methodology and early results of analyzing NS5A data.
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Kawasaki, S., Ho, T.B., Kanda, T., Yokosuka, O., Takabayashi, K., Le, N. (2011). Discovering Relationship between Hepatitis C Virus NS5A Protein and Interferon/Ribavirin Therapy. In: Theeramunkong, T., Kunifuji, S., Sornlertlamvanich, V., Nattee, C. (eds) Knowledge, Information, and Creativity Support Systems. Lecture Notes in Computer Science(), vol 6746. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24788-0_8
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DOI: https://doi.org/10.1007/978-3-642-24788-0_8
Publisher Name: Springer, Berlin, Heidelberg
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