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Comparing Discrete and Piecewise Affine Differential Equation Models of Gene Regulatory Networks

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Information Processign in Cells and Tissues (IPCAT 2012)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 7223))

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Abstract

We compare the discrete asynchronous logical modeling formalism for gene regulatory networks due to R. Thomas with piecewise-affine differential equation models. We show that although the two approaches are based on equivalent information, the resulting qualitative dynamics are different.

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Author information

Authors and Affiliations

  1. DFG Research Center Matheon, Freie Universität Berlin, Arnimallee 6, D-14195, Berlin, Germany

    Shahrad Jamshidi, Heike Siebert & Alexander Bockmayr

Authors
  1. Shahrad Jamshidi
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  2. Heike Siebert
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  3. Alexander Bockmayr
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Editor information

Editors and Affiliations

  1. Department of Electronics, University of York, YO10 5DD, York, UK

    Michael A. Lones  & Stephen L. Smith  & 

  2. MRC Laboratory of Molecular Biology, Hills Road, CB2 0QH, Cambridge, UK

    Sarah Teichmann

  3. The Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland

    Felix Naef

  4. Department of Electronics, University of York, YO10 5DD, York, UK

    James A. Walker  & Martin A. Trefzer  & 

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© 2012 Springer-Verlag Berlin Heidelberg

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Jamshidi, S., Siebert, H., Bockmayr, A. (2012). Comparing Discrete and Piecewise Affine Differential Equation Models of Gene Regulatory Networks. In: Lones, M.A., Smith, S.L., Teichmann, S., Naef, F., Walker, J.A., Trefzer, M.A. (eds) Information Processign in Cells and Tissues. IPCAT 2012. Lecture Notes in Computer Science, vol 7223. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28792-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-28792-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-28791-6

  • Online ISBN: 978-3-642-28792-3

  • eBook Packages: Computer ScienceComputer Science (R0)

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