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Complex Detection in Protein-Protein Interaction Networks: A Compact Overview for Researchers and Practitioners

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Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics (EvoBIO 2012)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 7246))

Abstract

The availability of large volumes of protein-protein interaction data has allowed the study of biological networks to unveil the complex structure and organization in the cell. It has been recognized by biologists that proteins interacting with each other often participate in the same biological processes, and that protein modules may be often associated with specific biological functions. Thus the detection of protein complexes is an important research problem in systems biology. In this review, recent graph-based approaches to clustering protein interaction networks are described and classified with respect to common peculiarities. The goal is that of providing a useful guide and reference for both computer scientists and biologists.

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Author information

Authors and Affiliations

  1. Institute for High Performance Computing and Networking, National Research Council of Italy, CNR-ICAR, via P. Bucci 41C, 87036, Rende, CS, Italy

    Clara Pizzuti & Simona E. Rombo

  2. DEIS, Universitá della Calabria, via P. Bucci 41C, 87036, Rende, CS, Italy

    Simona E. Rombo

  3. Department of Computer Science, Radboud University, Nijmegen, The Netherlands

    Elena Marchiori

Authors
  1. Clara Pizzuti
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  2. Simona E. Rombo
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  3. Elena Marchiori
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Editor information

Editors and Affiliations

  1. Department of Animal Production Epidemiology and Ecology, University of Torino, Via Leonardo da Vinci 44, 10095, Grugliasco, (TO), Italy

    Mario Giacobini

  2. Universidade Nove de Lisboa, ISEGI, 1070-312 Lisboa, Portugal and University of Milano-Bicocca, D.I.S.Co., Viale Sarca 336, 20126 Milan, Italy

    Leonardo Vanneschi

  3. Center for Human Genetics Research, Department of Biomedical Informatics, Vanderbilt University, 519 Light Hall, 37232, Nashville, TN, USA

    William S. Bush

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Pizzuti, C., Rombo, S.E., Marchiori, E. (2012). Complex Detection in Protein-Protein Interaction Networks: A Compact Overview for Researchers and Practitioners. In: Giacobini, M., Vanneschi, L., Bush, W.S. (eds) Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics. EvoBIO 2012. Lecture Notes in Computer Science, vol 7246. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29066-4_19

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  • DOI: https://doi.org/10.1007/978-3-642-29066-4_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-29065-7

  • Online ISBN: 978-3-642-29066-4

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