Skip to main content

Iterative Reconstruction with Monte Carlo Based System Matrix for Dedicated Breast PET

  • Conference paper
Breast Imaging (IWDM 2012)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 7361))

Included in the following conference series:

  • 2860 Accesses

Abstract

Increasing sensitivity by reducing the ring diameter of breast PET system may degrade image performance at field of view periphery. In this work, the authors present a framework for computing and incorporating an accurate system model of breast PET utilizing GATE Monte Carlo simulation to compensate for this performance degradation. The system matrix (SM) generation count statistics was maximized by taking into account the geometric symmetry of the scanner. The SM was incorporated into MLEM reconstruction and compared with the Siddon ray-tracing algorithm to evaluate point source resolution and contrast recovery coefficient (CRC) of hot spheres at various radial locations. Both spatial resolution and CRC using SM based MLEM was approximately position invariant, whereas the CRC and spatial resolution with Siddon based MLEM was substantially lower for locations near the periphery of the FOV. The CRC vs noise tradeoff was markedly better with the SM based MLEM.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Champion, L., Brain, E., Giraudet, A.L., Le Stanc, E., Wartski, M., Edeline, V., Madar, O., Bellet, D., Pecking, A., Alberini, J.L.: Breast cancer recurrence diagnosis suspected on tumor marker rising: value of whole-body 18FDG-PET/CT imaging and impact on patient management. Cancer 117(8), 1621–1629 (2011)

    Article  Google Scholar 

  2. Murthy, K., Aznar, M., Thompson, C.J., Loutfi, A., Lisbone, R., Gagnon, J.H.: Results of preliminary clinical trials of the positron emission mammography system PEM-I: a dedicated breast imaging system producing glucose metabolic images using FDG. J. Nucl. Med. 41, 1851–1858 (2000)

    Google Scholar 

  3. Zhang, Y., Ramirez, R., Li, H., Liu, S., An, S., Wang, C., Baghaei, H., Wong, W.H.: The system design, engineering architecture and preliminary results of a lower-cost high-sensitivity high-resolution Positron Emission Mammography Camera. In: IEEE NSS Conf. Rec., pp. M10–M138 (2008)

    Google Scholar 

  4. Bowen, S.L., Wu, Y., Chaudhari, A.J.: Initial Characterization of a dedicated breast PET/CT scanner during human imaging. JNM 50, 1401–1408 (2009)

    Google Scholar 

  5. Kadrmas, D.J.: LOR-OSEM: statistical PET reconstruction from raw line-of-response histograms. Phys. Med. Biol. 49, 4731–4744 (2004)

    Article  Google Scholar 

  6. Staelens, S., Strul, D., Santin, G., Vandenberghe, S., Koole, M., D’Asseler, Y., Lemahieu, I., Van de Walle, R.: Monte Carlo simulations of a scintillation camera using GATE: validation and application modelling. Phys. Med. Biol. 48, 3021–3042 (2003)

    Article  Google Scholar 

  7. Siddon, R.L.: Fast calculation of the exact radiological path for a three-dimensional CT array. Med. Phys. 12(2), 252–256 (1985)

    Article  Google Scholar 

  8. Panin, V., Kehren, F., Michael, C., Casey, M.: Fully 3-D PET reconstruction using system matrix derived from point source measurements. IEEE Trans. Med. Imaging. 25, 907–921 (2006)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Saha, K., Straus, K.J., Glick, S.J. (2012). Iterative Reconstruction with Monte Carlo Based System Matrix for Dedicated Breast PET. In: Maidment, A.D.A., Bakic, P.R., Gavenonis, S. (eds) Breast Imaging. IWDM 2012. Lecture Notes in Computer Science, vol 7361. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31271-7_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-31271-7_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-31270-0

  • Online ISBN: 978-3-642-31271-7

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics