Abstract
In the cooperative kinase network, a kinase interacts with other kinases for sustaining cellular signaling processes that greatly influence the major functions of cells. Here a key question is how the interacting kinases form a filtering network to estimate the original signal in the presence of stochastic fluctuation caused by the interactions. In this short paper, a filter is designed to estimate the concentration of the molecular signal Ste20 of the MAPK (mitogen-activated protein kinase) cascade in budding yeast based on the Ste20-Ste11-Ste7 pathway, in which kinases interact with each other. The filter is tested in simulations and the result shows that the estimated signal can be used to recognize the original signal. It is concluded that the Ste20-Ste11-Ste7 pathway can be regulated to analyze cell cycle processes through the interactions among kinases in the MAPK cascade.
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© 2012 ICST Institute for Computer Science, Social Informatics and Telecommunications Engineering
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Liu, JQ., Nakano, T. (2012). A Filter for the Cooperative Kinase Network of Budding Yeast Saccharomyces cerevisiae . In: Suzuki, J., Nakano, T. (eds) Bio-Inspired Models of Network, Information, and Computing Systems. BIONETICS 2010. Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, vol 87. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32615-8_55
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DOI: https://doi.org/10.1007/978-3-642-32615-8_55
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-32614-1
Online ISBN: 978-3-642-32615-8
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