Abstract
In this paper we discuss the possibility of building advanced medical knowledge-based applications using a combination of two promising technologies: semantic web technologies for the representation of domain knowledge and known facts, and rule-based systems for the definition of rules for knowledge base. We developed a prototype web application GeneMap, which enables browsing on diseases and related genes, which are known to influence the development of a disease; the publicly available Diseasome Dataset is used as a source of semantically-annotated medical data. The prototype is used to show how the two technologies can be efficiently combined to improve both the performance of such applications and the possibility of discovering new patterns that could lead towards new medical knowledge.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Stevens, R., Goble, C.A., Bechhofer, S.: Ontology-based knowledge representation for bioinformatics. Brief Bioinformatics 1, 398–416 (2000)
Stephens, S., LaVigna, D., DiLascio, M., Luciano, J.: Aggregation of bioinformatics data using Semantic Web technology. Web Semantics: Science, Services and Agents on the World Wide Web 4(3), 216–221 (2006)
Pasquier, C.: Biological data integration using Semantic Web technologies. Biochimie 90(4), 584–594 (2008)
Podgorelec, V., Grasic, B., Pavlic, L.: Medical diagnostic process optimization through the semantic integration of data resources. Computer Methods and Programs in Biomedicine 95(2), S55–S67 (2009)
García-Sánchez, F., Fernández-Breis, J.T., Valencia-García, R., Gómez, J.M., Martínez-Béjar, R.: Combining Semantic Web technologies with Multi-Agent Systems for integrated access to biological resources. Journal of Biomedical Informatics 41(5), 848–859 (2008)
Mei, J., Bontas, E.P., Lin, Z.: OWL2Jess: A Transformational Implementation of the OWL Semantics. In: Chen, G., Pan, Y., Guo, M., Lu, J. (eds.) ISPA-WS 2005. LNCS, vol. 3759, pp. 599–608. Springer, Heidelberg (2005)
Ceusters, W., Smith, B., Flanagan, J.: Ontology and medical terminology: Why description logics are not enough. In: Proceedings of Towards an Electronic Patient Record, TEPR 2003, Boston, MA (2003)
Passin, T.B.: Explorers guide to Semantic Web. Manning, Greenwich (2004)
Manola, F., Miller, E. (eds.): RDF Primer. W3C Recommendation (2004)
McGuiness, D.L., Harmelen, F. (eds.): OWL Web Ontology Language Overview. W3C Recommendation (2004)
Lacy, L.W.: OWL: Representing Information Using the Web Ontology Language. Trafford Publishing (2005)
Horrocks, I., Patel-Schneider, P.F., Boley, H., Tabet, S., Grosof, B., Dean, M.: SWRL: A Semantic Web Rule Language Combining OWL and RuleML. W3C Consortium (2004), http://www.w3.org/Submission/SWRL/
Browne, P.: JBoss Drools Business Rules. Packt Publishing, Birmingham (2009)
Jena - A Semantic Web Framework for Java, http://jena.sourceforge.net/
Friedman-Hill, E.: Jess in Action: Java Rule-Based Systems. Manning Publications, Greenwich (2003)
Rawlings, C.J., Searls, D.B.: Computational gene discovery and human disease. Current Opinion in Genetics & Development 7(3), 416–423 (1997)
Gudivada, R.C., Qu, X.A., Chen, J., Jegga, A.G., Neumann, E.K., Aronow, B.J.: Identifying disease-causal genes using Semantic Web-based representation of integrated genomic and phenomic knowledge. Journal of Biomedical Informatics 41(5), 717–729 (2008)
Diseasome Dataset, http://www4.wiwiss.fu-berlin.de/diseasome/
The DrugBank Database, http://www.drugbank.ca/
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Podgorelec, V., Gradišnik, M. (2012). Combining Semantic Web Technologies and Rule-Based Systems for Building Advanced Medical Applications. In: Cipolla-Ficarra, F., Veltman, K., Verber, D., Cipolla-Ficarra, M., Kammüller, F. (eds) Advances in New Technologies, Interactive Interfaces and Communicability. ADNTIIC 2011. Lecture Notes in Computer Science, vol 7547. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34010-9_21
Download citation
DOI: https://doi.org/10.1007/978-3-642-34010-9_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-34009-3
Online ISBN: 978-3-642-34010-9
eBook Packages: Computer ScienceComputer Science (R0)