Abstract
Experimental evidence shows that most tumors express the histamine synthesizing enzyme, L-histidine decarboxylase [1]. These tumor cells trigger sporadic reactions when they come in contact with histamine cells. In order to suppress these reactions, antihistamine drugs are used which competitively block the receptor mediated response of a tumor cell. We describe the effect of antihistamine drugs on the tumor cells, confirming whether these antihistamine drugs tend to increase or rather decrease the development of a brain tumor.
Drug target sites will be analyzed for similar proteins surrounding the brain tumor .These target sites alignment with similar proteins will open up the conserved regions. Protein motifs in the conserved regions that are over expressed and involved in tumor growth will be identified. The proteins identified will be docked with antihistamine drugs. Results will be analyzed by the scoring function of the algorithms. Selection of drug molecules may help us to design an anti neo plastic agent that can be therapeutically targeted to treat brain tumor.
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Feroz, S., Habib, A., Siddiqua, M., Saleem, S., Shar, N.A., Jafri, A.R. (2012). Association of Anti-Histamine Drugs with Brain Tumor. In: Huang, T., Zeng, Z., Li, C., Leung, C.S. (eds) Neural Information Processing. ICONIP 2012. Lecture Notes in Computer Science, vol 7663. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34475-6_2
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DOI: https://doi.org/10.1007/978-3-642-34475-6_2
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