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Automatic Detection of Osteolytic Lesions in Rat Femur With Bone Metastases

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Bildverarbeitung für die Medizin 2013

Part of the book series: Informatik aktuell ((INFORMAT))

Zusammenfassung

A method for the automatic detection of osteolytic lesions caused by bone metastases is presented. Osteolytic means that bone mass is lost and these lesions are visible as holes in the bone structure. For the analysis of the process of metastases and their response to therapies the measurement of these lesions is neccessary. As manual segmentation of all lesions is too complex for a larger study, automatic tools are needed. The challenging task of measuring missing structures is solved here by comparison of a modified bone with a healthy model. The algorithm is tested on rat femur bones. First tests have shown that the presented algorithm can be used for the global identification of osteolytic regions.

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Literatur

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Author information

Authors and Affiliations

  1. Division of Medical Physics in Radiation Oncology, DKFZ, Heidelberg, Deutschland

    Andrea Fränzle & Rolf Bendl

  2. Division of Medical Physics in Radiology, DKFZ, Heidelberg, Deutschland

    Maren Bretschi & Tobias Bäuerle

  3. Department of Medical Informatics, Heilbronn University, Heilbronn, Deutschland

    Rolf Bendl

Authors
  1. Andrea Fränzle
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  2. Maren Bretschi
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  3. Tobias Bäuerle
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  4. Rolf Bendl
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Corresponding author

Correspondence to Andrea Fränzle .

Editor information

Editors and Affiliations

  1. Abt. Med./Biol.Inform./H0100, Deutsches Krebsforschungzentrum (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Hans-Peter Meinzer

  2. Inst. Medizinische Informatik, RWTH Aachen, Pauwelsstr. 30, Aachen, 52074, Germany

    Thomas Martin Deserno

  3. , Institut für Medizinische Informatik, Universität zu Lübeck, Ratzeburger Allee 160, Lübeck, 23562, Germany

    Heinz Handels

  4. Charité Campus Benjamin Franklin, Inst. Medizinische Informatik,, Universitätsklinikum Berlin, Hindenburgdamm 30, Berlin, 12200, Berlin, Germany

    Thomas Tolxdorff

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© 2013 Springer-Verlag Berlin Heidelberg

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Fränzle, A., Bretschi, M., Bäuerle, T., Bendl, R. (2013). Automatic Detection of Osteolytic Lesions in Rat Femur With Bone Metastases. In: Meinzer, HP., Deserno, T., Handels, H., Tolxdorff, T. (eds) Bildverarbeitung für die Medizin 2013. Informatik aktuell. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36480-8_55

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