Abstract
Gene expression profiles produced by Microarray present a potential method for exploring the relationship between genes and brain. Here we analyzed the human gene expression levels among eight brain regions, including frontal lobe, Insula, limblic lobe, occipital lobe, parietal lobe, temporal lobe, basal ganglia and other cerebral nuclei. Top 45 schizophrenia candidate genes(179 probes) expression levels were compared between each two of these regions. Strikingly, 66.7% gene(83.2% probe) expression in basal ganglia distinguished from other regions. The great variation of the schizophrenia candidate gene expression in different brain regions indicated there is different neuropathologic mechanisms regulated by these candidate genes to this disease and basal ganglia would be the expression center of schizophrenia candidate genes.
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Lu, X., Liu, P., Zeng, Ll., Li, R., Hu, D. (2013). Schizophrenia Candidate Genes Specific to Human Brain Region Are Restricted to Basal Ganglia. In: Yang, J., Fang, F., Sun, C. (eds) Intelligent Science and Intelligent Data Engineering. IScIDE 2012. Lecture Notes in Computer Science, vol 7751. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36669-7_69
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DOI: https://doi.org/10.1007/978-3-642-36669-7_69
Publisher Name: Springer, Berlin, Heidelberg
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