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Semantic Rule-Based Determination of Cancer Stages from Free-Text Radiology Reports

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Advances in Biomedical Infrastructure 2013

Part of the book series: Studies in Computational Intelligence ((DSCC,volume 477))

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Abstract

Cancer staging provides a basis not only for determining proper treatments for a patient but also for making future national-wide health plans. Despite its benefits, it is very difficult to obtain staging data because it is not commonly performed for all cancer patients or simply not collected. Moreover, it requires medical experts to do the analysis, incurring expensive cost. In this paper, we propose a method for semantic rule based determination of a cancer stage, which is considering a semantic type (e.g. body part, organ, or organ component). Compared to previous work, our work is unique in that we utilize radiology reports instead of pathological report since they are more available. Moreover, we argue that a rule-based approach is more suitable for cancer staging than machine learning because the international staging protocols specify certain conditions for determining stages. Since semantic type of words should be considered to determine the cancer stage and construct rules, we construct rules using MetaMap, which provides a meta-thesaurus of UMLS (Unified Medical Language System) for medical text. Based on our semantic rules, TNM (Tumor Nodes Metastasis) stages are determined for 275 reports of liver cancer. From our experiments, whole performance are highly incremented than machine learning approach.

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References

  1. Varotti, G., Ramacciato, G., Ercolani, G., Grazi, G.L., Vetrone, G., Cescon, M., Del Gaudio, M., Ravaioli, M., Ziparo, V., Lauro, A., Pinna, A.: Comparison between the fifth and sixth editions of the AJCC/UICC TNM staging systems for hepatocellular carcinoma: mul-ticentric study on 393 cirrhotic resected patients. European Journal of Surgical Oncology 31(7), 760–767 (2005)

    Article  Google Scholar 

  2. Okuda, K.: Natural History of Hepatocellular Carcinomaand Prognosis in Relation to Treatment. CANCER 56, 918–928 (1983)

    Article  Google Scholar 

  3. Talian, L.I.I., Lip, P.R.C.: A New Prognostic System for Hepatocellular Carcinoma: A Retrospective Study of 435 Patients. HEPATOLOGY 28(3), 751–755 (1998)

    Article  Google Scholar 

  4. Lu, W., Dong, J., Huang, Z., Guo, D., Liu, Y., Shi, S.: Comparison of four current staging systems for Chinese patients with hepatocellular carcinoma undergoing curative resection: Okuda, CLIP, TNM and CUPI. Journal of Gastroenterology and Hepatology 23(12), 1874–1878 (2008)

    Article  Google Scholar 

  5. Ueno, G., Tanabe, S.: Prognostic performance of the new classification of primary liver cancer of Japan (4th edition) for patients with hepatocellular carcinoma: a validation anal-ysis. Hepatol Res. 24(4), 395–403 (2002)

    Article  Google Scholar 

  6. Kovalerchuk, B., Vityaev, E., Ruiz, J.F.: Design of consistent system for radiologists to support breast cancer diagnosis. In: Proc. Joint Conf Information Sciences, vol. 2, pp. 118–121 (1997)

    Google Scholar 

  7. McCowan, I., Moore, D.: Classification of cancer stage from free-text histology reports. Engineering in Medicine and 1, 5153–5156 (2006)

    Google Scholar 

  8. McCowan, I., Moore, D., Nguyen, A., Bowman, R.V., Clarke, B.E., Duhig, E.E., Fry, M.J.: Collection of cancer stage data by classifying free-text medical reports. Journal of the American Medical Informatics Association 14(6), 736 (2007)

    Article  Google Scholar 

  9. Nguyen, A.N., Lawley, M.J., Hansen, D.P., Bowman, R.V., Clarke, B.E., Duhig, E.E., Colquist, S.: Symbolic rule-based classification of lung cancer stages from free-text pa-thology reports. Journal of the American Medical Informatics Association, JAMIA 17(4), 440–445 (2010)

    Article  Google Scholar 

  10. Yu, H., Hripcsak, G.: Mapping abbreviations to full forms in biomedical articles. Journal of the American Medical Informatics Association, 262–272 (2002)

    Google Scholar 

  11. Hearst, M.A., Schwartz, A.S.: A simple algorithm for identifying abbreviation definitions in biomedical text. In: Pacific Symposium on Biocomputing, vol. 8, pp. 451–462 (2003)

    Google Scholar 

  12. Sohn, S., Comeau, D.C., Kim, W., Wilbur, W.J.: Abbreviation definition identification based on automatic precision estimates. BMC Bioinformatics 9, 402 (2008)

    Article  Google Scholar 

  13. Pakhomov, S.: Semi-supervised maximum entropy based approach to acronym and ab-breviation normalization in medical texts. In: The Association for Computational Linguistics (ACL), pp. 160–167 (July 2002)

    Google Scholar 

  14. Stevenson, M., Guo, Y., Amri, A.A.: Disambiguation of biomedical abbreviations. In: Proceedings of the Workshop on BioNLP, pp. 71–79 (June 2009)

    Google Scholar 

  15. International Health Terminology Standards Development Organisation. SNOMED Clin-ical Terms User Guide, http://www.ihtsdo.org/snomed-ct/

  16. Chang, J.: Creating an online dictionary of abbreviations from MEDLINE. Journal of the American Medical Informatics Association 9(6), 612–620 (2002)

    Article  Google Scholar 

  17. NIH, Unified Medical Language System (UMLS), http://www.nlm.nih.gov/research/umls/

  18. Aronson, A.R., Lang, F.-M.: An overview of MetaMap: historical perspective and re-cent advances. Journal of the American Medical Informatics Association, JAMIA 17(3), 229–236 (2010)

    Google Scholar 

  19. Chapman, W.W., Bridewell, W., Hanbury, P., Cooper, G.F., Buchanan, B.G.: A simple algorithm for identifying negated findings and diseases in discharge summaries. Journal of Biomedical Informatics 34(5), 301–310 (2001)

    Article  Google Scholar 

  20. Schwartz, A.S., Hearst, M.A.: A simple algorithm for identifying abbreviation defini-tions in biomedical text. In: Pacific Symposium on Biocomputing, vol. 8, pp. 451–462 (2003)

    Google Scholar 

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Correspondence to Sangsoo Nam .

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Nam, S., Oh, HS., Kim, JB., Myaeng, SH., Choi, J. (2013). Semantic Rule-Based Determination of Cancer Stages from Free-Text Radiology Reports. In: Sidhu, A., Dhillon, S. (eds) Advances in Biomedical Infrastructure 2013. Studies in Computational Intelligence, vol 477. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37137-0_6

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  • DOI: https://doi.org/10.1007/978-3-642-37137-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37136-3

  • Online ISBN: 978-3-642-37137-0

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