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Simulation of Prokaryotic Genome Evolution Subjected to Mutational Pressures Associated with DNA Replication

  • Conference paper
Biomedical Engineering Systems and Technologies (BIOSTEC 2012)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 357))

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Abstract

Each of two differently replicated DNA strands (leading and lagging) is subjected to the distinct mutational pressure associated with its synthesis. To simulate the influence of these pressures on the gene and genome evolution we worked out a computer model in which protein coding sequences were mutated according to the direct pressure (of the strand on which they were located), the reverse pressure (of the opposite strand), and the changing pressure (when the latter pressures were applied alternately). Simulated genomes were eliminated by the occurrence of stop codons in the gene sequences and the loss of their coding properties. The selection against stop codons appeared more deleterious than for coding signal. The leading strand pressure eliminated more genes because of the coding signal loss whereas the lagging strand pressure generated more stop codons. Generally, the reverse and changing pressures destroyed the coding signal weaker than the direct pressure.

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Authors and Affiliations

  1. Department of Genomics, Faculty of Biotechnology, University of Wrocław, ul. Przybyszewskiego 63/77, 51-148, Wrocław, Poland

    Paweł Błażej, Paweł Mackiewicz & Stanisław Cebrat

Authors
  1. Paweł Błażej
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  2. Paweł Mackiewicz
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  3. Stanisław Cebrat
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Editor information

Editors and Affiliations

  1. University of Porto, Portugal

    Joaquim Gabriel

  2. Institute of Information Theory and Automation of the ASCR, Pod vodárenskou věží 4, CZ-182 08, Prague 8, Czech Republic

    Jan Schier

  3. Dept. of Electrical Engineering, ESAT-SCD(SISTA), Katholieke Universiteit Leuven, Belgium

    Sabine Van Huffel

  4. University of Toulouse, France

    Emmanuel Conchon

  5. University of Coimbra, Portugal

    Carlos Correia

  6. IST - Technical University of Lisbon,, Av.Rovisco Pais, 1, 1049-001, Lisbon, Portugal

    Ana Fred

  7. Institute of Telecommunication, Lisboa, Portugal

    Hugo Gamboa

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Błażej, P., Mackiewicz, P., Cebrat, S. (2013). Simulation of Prokaryotic Genome Evolution Subjected to Mutational Pressures Associated with DNA Replication. In: Gabriel, J., et al. Biomedical Engineering Systems and Technologies. BIOSTEC 2012. Communications in Computer and Information Science, vol 357. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38256-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-38256-7_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38255-0

  • Online ISBN: 978-3-642-38256-7

  • eBook Packages: Computer ScienceComputer Science (R0)

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