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Tumor Gene Expressive Data Classification Based on Locally Linear Representation Fisher Criterion

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Intelligent Computing Theories and Technology (ICIC 2013)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 7996))

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Abstract

In this paper, a discriminant manifold learning method based on Locally Linear Embedding (LLE), which is named Locally Linear Representation Fisher Criterion (LLRFC), is proposed for the classification of tumor gene expressive data. In the proposed LLRFC, an inter-class graph and intra-class graph is constructed based on the class information of tumor gene expressive data, where the weights between nodes in both graph are optimized using locally linear representation trick. Moreover, a Fisher criterion is modeled to maximize the inter-class scatter and minimize the intra-class scatter simultaneously. Experiments on some benchmark tumor gene expressive data validate its efficiency.

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References

  1. Alon, A.: Broad Patterns of Gene Expression Revealed by Clustering Analysis of Tumorand Normal Colon Tissues Probed by Clustering Analysis of Tumor and Normal Colon Tissues Probed by Oligonucleotide Arrays. Proc. Natl Acad. Sci. 96, 6745–6750 (1999)

    Article  Google Scholar 

  2. Bittner, M.: Molecular Classification of Cetaceous Malignant Melanoma by Gene Expression Profiling. Nature 406, 536–540 (2000)

    Article  Google Scholar 

  3. Furey, T.S., Cristianini, N., Duffy, N., Bednarski, D.W., Schummer, M., Haussler, D.: Support Vector Machines Classification and Validation of Cancer Tissue Samples Using Microarray Expression Data. Bioinformatics 16, 906–914 (2000)

    Article  Google Scholar 

  4. Hoyer, P.O.: Non-negative Matrix Factorization with Sparseness Constraints. J. Mach.Learn. Res. 5, 1457–1469 (2004)

    MathSciNet  MATH  Google Scholar 

  5. Gao, Y., Church, G.: Improving Molecular Cancer Class Discovery Through Sparse Nonnegative Matrix Factorization. Bioinformatics 21, 3970–3975 (2005)

    Article  Google Scholar 

  6. Huang, D.S., Zheng, C.H.: Independent Component Analysis Based Penalized Discriminate Method for Tumor Classification Using Gene Expression Data. Bioinformatics 22, 1855–1862 (2006)

    Article  Google Scholar 

  7. Comon, P.: Independent Component Analysis— A New Concept. Signal Processing 36, 287–314 (1994)

    Article  MATH  Google Scholar 

  8. Chiappetta, P., Roubaud, M.C., Torresani, B.: Blind Source Separation and the Analysis of Microarray Data. Journal of Computational Biology 11, 1090–1109 (2004)

    Article  Google Scholar 

  9. Roweis, S.T., Saul, L.K.: Nonlinear dimensionality reduction by locally linear embedding. Science 290, 2323–2326 (2000)

    Article  Google Scholar 

  10. Saul, L.K., Roweis, S.T.: Think Globally, Fit Locally: Unsupervised Learning of Low Dimensional Manifolds. J. Mach. Learning Res. 4, 119–155 (2003)

    MathSciNet  Google Scholar 

  11. Li, B., Zheng, C., Huang, D.: Locally linear discriminant embedding: an efficient method for face recognition. Pattern Recognition 41(12), 3813–3821 (2008)

    Article  MATH  Google Scholar 

  12. He, X., Cai, D., Yan, S.: Neighborhood preserving embedding. In: Proceedings of the 10th IEEE International Conference on Computer Vision, pp. 1208–1213 (2005)

    Google Scholar 

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Li, B., Tian, BB., Liu, J. (2013). Tumor Gene Expressive Data Classification Based on Locally Linear Representation Fisher Criterion. In: Huang, DS., Jo, KH., Zhou, YQ., Han, K. (eds) Intelligent Computing Theories and Technology. ICIC 2013. Lecture Notes in Computer Science(), vol 7996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39482-9_51

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  • DOI: https://doi.org/10.1007/978-3-642-39482-9_51

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-39481-2

  • Online ISBN: 978-3-642-39482-9

  • eBook Packages: Computer ScienceComputer Science (R0)

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