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Data Warehouses in Bioinformatics

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Approaches in Integrative Bioinformatics

Abstract

The progress in the area of biological research in recent years has led to a multiplicity of different databases and information systems. Molecular biology deals with complex problems and an enormous amount of versatile data will be produced by high-throughput techniques. Hence, the total number of databases, as well as the data itself, is continuously increasing, and with it the distribution and heterogeneity of the data rises. The importance of database integration has been recognized for many years. Therefore, this chapter presents the problems in database integration as well as a small selection of well-known existing integration systems which have been developed. Finally, this chapter presents an in-house data warehouse approach for biological data. Integrated data is the basis for network analysis, reconstruction, and visualization.

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Notes

  1. 1.

    http://www.ncbi.nlm.nih.gov/blast/fasta.shtml

References

  1. Bauer A, Günzel H (2004) Data-Warehouse-Systeme, XVI, 592 S.: graph. Darst. dpunkt-Verl., Heidelberg. 3-89864-251-8

    Google Scholar 

  2. Baumbach J (2007) CoryneRegNet 4.0 – a reference database for corynebacterial gene regulatory networks. BMC Bioinform 8:429

    Google Scholar 

  3. Baumbach J, Brinkrolf K, Czaja LF, Rahmann S, Tauch A (2006) CoryneRegNet: an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks. BMC Genomics 7:24

    Article  Google Scholar 

  4. Chen I-MA, Markowitz VM (1995) An overview of the object protocol model (OPM) and the OPM data management tools. Inf Syst 20(5):393–418. issn:0306-4379, doi:10.1016/0306-4379(95)00021-U, Elsevier Science, Oxford

    Google Scholar 

  5. Chen M, Hariharaputran S, Hofestädt R, Kormeier B, Spangardt S (2009) Petri net models for the semi-automatic construction of large scale biological networks. Nat Comput. Springer, Netherlands, 1567-7818 (Print) 1572-9796 (Online), doi:10.1007/s11047-009-9151-y

    Google Scholar 

  6. Choi C, Munch R, Leupold S, Klein J, Siegel I, Thielen B, Benkert B, Kucklick M, Schobert M, Barthelmes J, Ebeling C, Haddad I, Scheer M, Grote A, Hiller K, Bunk B, Schreiber K, Retter I, Schomburg D, Jahn D (2007) SYSTOMONAS–an integrated database for systems biology analysis of Pseudomonas. Nucl Acids Res 35:D533–D537

    Article  Google Scholar 

  7. Conrad S (1997) Föderierte Datenbanksysteme – Konzepte der Datenintegration, XI, 331 S.: graph. Darst., Springer, Berlin [u.a.]. 3-540-63176-3

    Google Scholar 

  8. Etzold T, Ulyanov A, Argos P (1996) SRS: information retrieval system for molecular biology data banks. Meth Enzymol 266:114–128

    Google Scholar 

  9. Haas LM, Schwarz PM, Kodali P, Kotlar E, Rice JE, Swope WC (2001) DiscoveryLink: a system for integrated access to life sciences data sources. IBM Syst J 40(2):489–511. 0018-8670, IBM Corp., Riverton

    Google Scholar 

  10. Hippe K, Kormeier B, Janowski S, Töpel T, Hofestädt R (2010) DAWIS-M.D. – a data warehouse system for metabolic data. GI Jahrestag 2:720–725

    Google Scholar 

  11. Janowski S, Kormeier B, Töpel T, Hippe K, Hofestädt R, Willassen N, Friesen R, Rubert S, Borck D, Haugen P, Chen M (2010) Modeling of cell-cell communication processes using Petri nets in the example of quorum sensing. Silico Biol 10:182–203. Studies in health technology and informatics, Biological petri nets, vol 162. doi:10.3233/978-1-60750-704-8-182

    Google Scholar 

  12. Köhler J, Baumbach J, Taubert J, Specht M, Skusa A, Rüegg A, Rawlings C, Verrier P, Philippi S (2006) Graph-based analysis and visualization of experimental results with ONDEX. Bioinformatics 22:1383–1390

    Article  Google Scholar 

  13. Kormeier B, Hippe K, Töpel T, Hofestädt R (2009) CardioVINEdb: a data warehouse approach for integration of life science data in cardiovascular diseases, Im Focus das Leben. Beiträge der 39. Jahrestagung der Gesellschaft für Informatik e.V. (GI), S. Fischer et al. (Hrsg.), INFORMATIK 2009, Koellen Druck+Verlag., Bonn, 40,704–708

    Google Scholar 

  14. Kormeier B, Hippe K, Arrigo P, Topel T, Janowski S, Hofestädt R (2010) Reconstruction of biological networks based on life science data integration. J Integr Bioinform 7(2). doi:10.2390/biecoll-jib-2010-146

    Google Scholar 

  15. Lee TJ, Pouliot Y, Wagner V, Gupta P, Stringer-Calvert DW, Tenenbaum JD, Karp PD (2006) BioWarehouse: a bioinformatics database warehouse toolkit. BMC Bioinform 7:170

    Article  Google Scholar 

  16. Leser U, Naumann F (2006) Informations integration. Dpunkt Verlag, Heidelberg

    Google Scholar 

  17. Pauling J, Rottger R, Tauch A, Azevedo V, Baumbach J (2012) CoryneRegNet 6.0–updated database content, new analysis methods and novel features focusing on community demands. Nucl Acids Res 40(Database issue):D610–D614

    Google Scholar 

  18. Shah SP, Huang Y, Xu T, Yuen MM, Ling J, Ouellette BF (2005) Atlas – a data warehouse for integrative bioinformatics. BMC Bioinform 6:34

    Article  Google Scholar 

  19. Sheth AP, Larson JA (1990) Federated database systems for managing distributed, heterogeneous, and autonomous databases. ACM Comput Surv 22(3):183–236. 0360–0300, doi:10.1145/96602.96604, ACM, New York

    Google Scholar 

  20. Stevens R, Baker P, Bechhofer S, Ng G, Jacoby A, Paton NW, Goble CA, Brass A (2000) TAMBIS: transparent access to multiple bioinformatics information sources. Bioinformatics 16:184–185

    Article  Google Scholar 

  21. Töpel T, Kormeier B, Klassen A, Hofestädt R (2008) BioDWH: a data warehouse kit for life science data integration. J Integr Bioinform 5(2):93. 1613-4516, http://dx.doi.org/10.2390/biecoll-jib-2008-93

  22. Trissl S, Rother K, Müller H, Steinke T, Koch I, Preissner R, Frömmel C, Leser U (2005) Columba: an integrated database of proteins, structures, and annotations. BMC Bioinform 6:81

    Article  Google Scholar 

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Correspondence to Benjamin Kormeier .

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Kormeier, B. (2014). Data Warehouses in Bioinformatics. In: Chen, M., Hofestädt, R. (eds) Approaches in Integrative Bioinformatics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41281-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-41281-3_4

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  • Online ISBN: 978-3-642-41281-3

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