Abstract
Protein structure prediction (PSP) problem is a multimodal problem that can be tackled efficiently by evolutionary algorithms. However, evolutionary algorithms often fail to find the global optima due to genetic drift while solving the complex problems with a lot of peaks in the fitness landscape. Therefore, the need to efficiently measure as well as maintaining population diversity has significant effects in performance of evolutionary algorithms. In this paper, we introduce a composite measure of population diversity by hybridizing the phenotypic properties along with the distribution of individuals in a population over the fitness landscape. We further propose a memory-based diversification technique for the maintenance and promotion of diversity to prevent occurrence of stuck condition in multimodal problems such as PSP. Experiments conducted on protein structure prediction with HP benchmark sequences for 3D cubic lattice model illustrate that the proposed techniques are useful in improving the optimization process in terms of convergence as well as for achieving the optimal energy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Crescenzi, P., Goldman, D., Papadimitriou, C.H., Piccolboni, A., Yannakakis, M.: On the complexity of protein folding. In: RECOMB, pp. 61–62 (1998)
Lau, K., Dill, K.A.: A lattice statistical mechanics model of the conformational and sequence spaces of proteins. Macromolecules 22(10), 3986–3997 (1989)
Islam, M.K., Chetty, M.: Clustered memetic algorithm with local heuristics for ab initio protein structure prediction. IEEE Trans. Evolutionary Computation 17(4), 558–576 (2013)
Unger, R., Moult, J.: Genetic algorithm for protein folding simulations. Journal of Molecular Biology 231(1), 75–81 (1993)
Santana, R., Larranaga, P., Lozano, J.A.: Protein folding in simplified models with estimation of distribution algorithms. IEEE Transactionson on Evolutionary Computation 12(4), 418–438 (2008)
Burke, E., Gustafson, S., Kendall, G.: Diversity in genetic programming: An analysis of measures and correlation with fitness. IEEE Trans. on Evolutionary Computation 8(1), 47–62 (2004)
Caponio, A., Cascella, G.L., Neri, F., Salvatore, N., Sumner, M.: A fast adaptive memetic algorithm for off-line and on-line control design of pmsm drives. IEEE Trans. on Systems Man and Cybernetics Part B, Special Issue on Memetic Algorithms 37(1), 28–41 (2007)
Tirronen, V., Neri, F., Karkkainen, T., Majava, K., Rossi, T.: A memetic differential evolution in filter design for defect detection in paper production. In: Giacobini, M. (ed.) EvoWorkshops 2007. LNCS, vol. 4448, pp. 320–329. Springer, Heidelberg (2007)
Nazmul, R., Chetty, M., Samudrala, R., Chalmers, D.: Protein structure prediction based on optimal hydrophobic core formation. In: IEEE Congress on Evolutionary Computation, pp. 1–9 (2012)
Neri, F., Toivanen, J., Cascella, G.L., Ong, Y.S.: An adaptive multimeme algorithm for designing hiv multidrag therapies. IEEE-ACM Trans. on Comput. Biology and Bioinformatics 4(2), 264–278 (2007)
Neri, F., Toivanen, J., Makinen, R.: An adaptive evolutionary algorithm with intelligent mutation local searchers for designing multidrug therapies for hiv. Applied Intellegence, Special Issue on Cdicine and Biology (2007)
Rosca, J.: Entropy driven adaptive representation. In: Proceedings of the Workshop on Genetic Programming: From Theory to Real world Application, pp. 23–32 (1995)
Grefenstette, J.J.: Genetic algorithms for changing environments. In: Parallel Problem Solving From Nature II, pp. 137–144 (1992)
Wang, H., Wang, D., Shengxiang, Y.: A memetic algorithm with adaptive hill climbing startegy for dynamic optimization problems. Soft Comput. 13(8-9), 763–780 (2009)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Nazmul, R., Chetty, M. (2013). Protein Structure Prediction with a New Composite Measure of Diversity and Memory-Based Diversification Strategy. In: Lee, M., Hirose, A., Hou, ZG., Kil, R.M. (eds) Neural Information Processing. ICONIP 2013. Lecture Notes in Computer Science, vol 8227. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-42042-9_80
Download citation
DOI: https://doi.org/10.1007/978-3-642-42042-9_80
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-42041-2
Online ISBN: 978-3-642-42042-9
eBook Packages: Computer ScienceComputer Science (R0)