Nonlinear Pharmacokinetical Modelling and Simulation

Summary

Profound pharmacological and pharmacokinetical studies of drugs are unavoidable in the modern realization of successfull therapy. Linear and nonlinear pharmacokinetical modelling and simulation enable dosage forms and dosage regimen design necessary for the optimal manufacturing, consumption and application of drugs. So the needful “in vivo” studies which are expensive, time consuming and sometimes delicate, can be minimized. The work deals with the analog-hybrid simulation of the concrete drug pharmacokinetics namely Cimetidine. In the six compartmental model also the first-pass effect with liver cumulation of drug, enterohepatic cycle with time changable parameter simulating food administration and corresponding time delay after the oral application of drug simulating dosage form desintegration were taken into account. The study was realized using analog-hybrid computer EAI-580 and the corresponding “in vivo” data.