Summary
The mathematical model of DIFRANCESCO and NOBLE (6) is a complex summary of experimental knowledge about electrophysiological processes in cardiac cell membranes. A simulation series was performed describing the role of theoretical model support in a concrete pharmacological problem giving rise to possible interpretation of our own experimental results compared to contradictory data from the literature. Model simulation suggest that the effects of potassium channel inhibiting substances on cardiac action potentials may be dependent on the duration of the action potential itself or the underlying individual constellation of ionic current components.
Zusammenfassung
Das mathematische Modell von DIFRANCESCO und NOBLE (6) stellt eine komplexe Zusammenfassung experimenteller Erkenntnisse von den elektrophysiologischen Vorgängen an Herzzellmembranen dar. Zu einer konkreten pharmakologischen Fragestellung wird eine Simulationsstudie beschrieben, die zur möglichen Erklärung eigener und scheinbar widersprüchlicher Resultate aus der Literatur geführt hat. Dabei ergab sich, daß die Wirkung von Substanzen, welche die Kaliumionenkanäle blockieren, auf das kardiale Aktionspotential verschiedenartig ausfällt in Abhängigkeit von der Dauer der Aktionspotentiale bzw. der aktuellen Konstellation verschiedener Stromkomponenten eines Zellsystems.
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© 1991 Springer-Verlag Berlin Heidelberg
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Hafner, D., Berger, F., Borchard, U., Stöcker, K. (1991). Simulation of the effects of potassium-channel inhibiting drugs on the duration of cardiac action potentials. In: Möller, D.P.F., Richter, O. (eds) Analyse dynamischer Systeme in Medizin, Biologie und Ökologie. Informatik-Fachberichte, vol 275. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77020-3_3
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DOI: https://doi.org/10.1007/978-3-642-77020-3_3
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