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Computation of DNA-Based Parameters from Chromosome Scans

  • Conference paper
Digitale Bildverarbeitung Digital Image Processing

Part of the book series: Informatik — Fachberichte ((INFORMATIK,volume 8))

Summary

In this paper algorithms are described and evaluated to compute DNA-based parameters of chromosomes in scanned metaphases. Four parameters are investigated: DNA content, DNA arm ratio, length and centromeric index. The coefficients of variation introduced by the successive steps are given and it is concluded, that the measuring errors are smaller than the errors due to preparation and staining procedures. Classification results obtained with these features are given.

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References

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Author information

Authors and Affiliations

  1. Pattern Recognition Group, Dept. of Applied Physics, Delft University of Technology, The Netherlands

    F. C. A. Groen & P. W. Verbeek

  2. Dept. of Histochemistry and Cytochemistry, State University Leyden, The Netherlands

    M. van der Ploeg

Authors
  1. F. C. A. Groen
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  2. P. W. Verbeek
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  3. M. van der Ploeg
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Editor information

Editors and Affiliations

  1. Institut für Informatik, Universität Hamburg, Schlüterstraße 70, 2000, Hamburg 13, Deutschland

    Hans-Hellmut Nagel

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© 1977 Springer-Verlag Berlin Heidelberg

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Groen, F.C.A., Verbeek, P.W., van der Ploeg, M. (1977). Computation of DNA-Based Parameters from Chromosome Scans. In: Nagel, HH. (eds) Digitale Bildverarbeitung Digital Image Processing. Informatik — Fachberichte, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95298-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-95298-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08169-2

  • Online ISBN: 978-3-642-95298-2

  • eBook Packages: Springer Book Archive

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