Abstract
Clinical Concept normalization is an essential task aiming to normalize recognized clinical concepts from clinical narratives. This paper presents a hybrid model combining traditional rule-based methods and a novel neural network to realize the normalization process. The experiment is set on MCN corpus and we generate candidates by modifying phrases and setting sieves to acquire terminologies from the UMLS system. Then the mentions are normalized through a flow of processes. Firstly, if mentions of testing data once appeared in the training data, the ontologies of mentions in training data are referred to. Secondly, we exert the exact matching between mentions and candidates after modifying phrases. Thirdly, a new deep neural network with an attention mechanism is designed for normalizing. If the above three methods failed to link the mention to its ontology, the first candidate in its candidate set will be recommended. The experimental results show our hybrid model performs better than both rule-based and deep learning methods and it also outperforms the baseline model of MCN corpus.
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References
Luo, Y.F., Sun, W., Rumshisky, A.: MCN: A comprehensive corpus for medical concept normalization. J. Biomed. Inform. 92, (2019). https://doi.org/10.1016/j.jbi.2019.103132
D’Souza, J., Ng, V.: Sieve-based entity linking for the biomedical domain. In: ACL-IJCNLP 2015—53rd Annual Meeting of the Association for Computational Linguistics and the 7th International Joint Conference on Natural Language Processing of the Asian Federation of Natural Language Processing, Proceedings of the Conference, pp. 297–302 (2015)
Bodenreider, O.: The Unified Medical Language System (UMLS): Integrating biomedical terminology. Nucleic Acids Res. 32, D267–D270 (2004). https://doi.org/10.1093/nar/gkh061
Rajani, N.F., Bornea, M., Barker, K.: Stacking with auxiliary features for entity linking in the medical domain. BioNLP. 39–47 (2017). https://doi.org/10.18653/v1/w17-2305
Li, H., Chen, Q., Tang, B., Wang, X., Xu, H., Wang, B., Huang, D.: CNN-based ranking for biomedical entity normalization. BMC Bioinform. 18, (2017). https://doi.org/10.1186/s12859-017-1805-7
Kim, Y.: Convolutional neural networks for sentence classification. In: EMNLP 2014—2014 Conf. Empir. Methods Nat. Lang. Process. Proc. Conf. 1746–1751 (2014). https://doi.org/10.3115/v1/d14-1181
Nguyễn, T.N., Nguyễn, T.M., Đặng, T.H.: Disease named entity normalization using pairwise learning to rank and deep learning
Wright, D., Katsis, Y., Mehta, R., Hsu, C.-N.: NormCo: deep disease normalization for biomedical knowledge base construction (2019)
Chung, J., Gulcehre, C., Cho, K., Bengio, Y.: Empirical evaluation of gated recurrent neural networks on sequence modeling. arXiv Prepr.: arXiv1412.3555 (2014)
Vaswani, A., Shazeer, N., Parmar, N., Uszkoreit, J., Jones, L., Gomez, A.N., Kaiser, Ł., Polosukhin, I.: Attention is all you need. In: Advances in Neural Information Processing Systems, pp. 5999–6009 (2017)
Devlin, J., Chang, M.-W., Lee, K., Toutanova, K.: BERT: pre-training of deep bidirectional transformers for language understanding (2018)
Uzuner, Ö., South, B.R., Shen, S., DuVall, S.L.: 2010 i2b2/VA challenge on concepts, assertions, and relations in clinical text. J. Am. Med. Inform. Assoc. 18, 552–556 (2011). https://doi.org/10.1136/amiajnl-2011-000203
Aronson, A.R.: Effective mapping of biomedical text to the UMLS Metathesaurus: the MetaMap program. In: Proceedings/AMIA Annual Symposium. AMIA Symposium, pp. 17–21. American Medical Informatics Association (2001)
Acknowledgements
This research was financially supported by the Open Research Fund from Shenzhen Research Institute of Big Data, under Grant No. 2019ORF01011. Meanwhile, Xiang Wan and Tsung-Hui Chang also gave us much help.
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Tang, C. et al. (2021). A Hybrid Model for Clinical Concept Normalization. In: Satapathy, S., Zhang, YD., Bhateja, V., Majhi, R. (eds) Intelligent Data Engineering and Analytics. Advances in Intelligent Systems and Computing, vol 1177. Springer, Singapore. https://doi.org/10.1007/978-981-15-5679-1_55
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DOI: https://doi.org/10.1007/978-981-15-5679-1_55
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