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Multi-class Glioma Classification from MRI Images Using 3D Convolutional Neural Networks

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Computer Vision and Image Processing (CVIP 2020)

Abstract

Glioma is a prevalent and deadly form of brain tumor. Most of the existing models have used 2D MRI slices for general tumor classification. In this paper, a 3D convolutional neural network has been proposed to automatically classify gliomas namely, astrocytoma, oligodendroglioma, and glioblastoma from MRI images. MRI modalities like T1, T1ce, FLAIR, and T2 are used for glioma classification. This step is essential for diagnosis and treatment planning for a patient. Manual classification is costly, time-consuming, and human-error prone. So, there is a need for accurate, robust, and automatic classification of glioma. Convolution neural networks have achieved state-of-the-art accuracy in many image processing classification tasks. In this work, 3D and 2D CNN models have been studied with multiple (T1, T1ce, FLAIR, and T2) and single (T1ce) MRI image modalities as input. The effect of segmentation of glioma on the classification accuracy has also been studied. The CNN models have been validated on the publicly available CPM-RadPath2019 dataset. It has been observed that the 3D CNN with segmented glioma along with multiple MRI modalities (T1, T1ce, FLAIR, and T2) has achieved an overall accuracy of 75.45%.

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References

  1. Afshar, P., Mohammadi, A., Plataniotis, K.N.: Brain tumor type classification via capsule networks. In: International Conference on Image Processing (ICIP), pp. 3129–3133. IEEE (2018)

    Google Scholar 

  2. Allen, N.J., Barres, B.A.: Glia—More than just brain glue. Nature 457(7230), 675–677 (2009)

    Article  Google Scholar 

  3. Bakas, S., et al.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-GBM collection. The Cancer Imaging Archive (2017)

    Google Scholar 

  4. Bakas, S., et al.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-LGG collection. The Cancer Imaging Archive, vol. 286 (2017)

    Google Scholar 

  5. Bakas, S., et al.: Advancing the cancer genome atlas glioma MRI collections with expert segmentation labels and radiomic features. Sci. Data 4, 170117 (2017)

    Article  Google Scholar 

  6. Chan, H.-W., Weng, Y.-T., Huang, T.-Y.: Automatic classification of brain tumor types with the MRI scans and histopathology images. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11993, pp. 353–359. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46643-5_35

    Chapter  Google Scholar 

  7. Cheng, J., et al.: Enhanced performance of brain tumor classification via tumor region augmentation and partition. PLoS ONE 10(10), e0140381 (2015)

    Article  Google Scholar 

  8. Erickson, B., Akkus, Z., Sedlar, J., Kofiatis, P.: Data from LGG-1p19qDeletion. The Cancer Imaging Archive (2017)

    Google Scholar 

  9. Ge, C., Gu, I.Y.H., Jakola, A.S., Yang, J.: Deep learning and multi-sensor fusion for glioma classification using multistream 2D convolutional networks. In: Engineering in Medicine and Biology Society (EMBC), pp. 5894–5897. IEEE (2018)

    Google Scholar 

  10. Ge, C., Gu, I.Y.H., Jakola, A.S., Yang, J.: Cross-modality augmentation of brain MR images using a novel pairwise generative adversarial network for enhanced glioma classification. In: International Conference on Image Processing (ICIP), pp. 559–563. IEEE (2019)

    Google Scholar 

  11. Kurc, T., et al.: Segmentation and classification in digital pathology for glioma research: challenges and deep learning approaches. Front. Neurosci. 14, 27 (2020)

    Article  Google Scholar 

  12. Louis, D.N., et al.: The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 131(6), 803–820 (2016)

    Article  Google Scholar 

  13. Menze, B.H., et al.: The multimodal brain tumor image segmentation benchmark (BRATS). IEEE Trans. Med. Imaging 34(10), 1993–2024 (2014)

    Article  Google Scholar 

  14. Myronenko, A.: 3D MRI brain tumor segmentation using autoencoder regularization. In: Crimi, A., Bakas, S., Kuijf, H., Keyvan, F., Reyes, M., van Walsum, T. (eds.) BrainLes 2018. LNCS, vol. 11384, pp. 311–320. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11726-9_28

    Chapter  Google Scholar 

  15. Nyúl, L.G., Udupa, J.K., Zhang, X.: New variants of a method of MRI scale standardization. IEEE Trans. Med. Imaging 19(2), 143–150 (2000)

    Article  Google Scholar 

  16. Sajjad, M., Khan, S., Muhammad, K., Wu, W., Ullah, A., Baik, S.W.: Multi-grade brain tumor classification using deep CNN with extensive data augmentation. J. Comput. Sci. 30, 174–182 (2019)

    Article  Google Scholar 

  17. Siegel, R.L., Miller, K.D., Jemal, A.: Cancer statistics, 2020. CA Cancer J. Clin. 70(1), 7–30 (2020)

    Article  Google Scholar 

  18. Xue, Y., et al.: Brain tumor classification with tumor segmentations and a dual path residual convolutional neural network from MRI and pathology images. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11993, pp. 360–367. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46643-5_36

    Chapter  Google Scholar 

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Correspondence to Subin Sahayam .

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Sahayam, S., Jayaraman, U., Teja, B. (2021). Multi-class Glioma Classification from MRI Images Using 3D Convolutional Neural Networks. In: Singh, S.K., Roy, P., Raman, B., Nagabhushan, P. (eds) Computer Vision and Image Processing. CVIP 2020. Communications in Computer and Information Science, vol 1376. Springer, Singapore. https://doi.org/10.1007/978-981-16-1086-8_29

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  • DOI: https://doi.org/10.1007/978-981-16-1086-8_29

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