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STFM: Enhancing Autism Spectrum Disorder Classification Through Ensemble Learning-Based Fusion of Temporal and Spatial fMRI Patterns

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PRICAI 2023: Trends in Artificial Intelligence (PRICAI 2023)

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Abstract

This paper presents the novel spatial and temporal fusion model (STFM), an effective approach for Autism Spectrum Disorder (ASD) detection and classification tasks using foundational machine learning models. Utilizing ensemble learning principles, STFM improves the classification performance by integrating weak classifiers. The process begins with the sliding window method applied to fMRI data, constructing brain networks through Pearson correlation calculation between brain regions. This infuses the network with both temporal and spatial patterns. Then, bidirectional LSTM (Bi-LSTM) and 2DCNN are applied for temporal and spatial feature extraction respectively. The model further ensures smoother data variations between patterns through interpolation, and utilizes a basic cross attention mechanism for fusion of patterns. The fused patterns are then classified by a simple SVM classifier. The presented STFM model demonstrates a remarkable classification accuracy of 70.42%, surpassing most fundamental machine learning models in ASD detection.

Z. Zhou, Y. Huang and Y. Wang—Equal contribution.

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References

  1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Washington, DC (2013)

    Google Scholar 

  2. Centers for disease control and prevention: Data & statistics on autism spectrum disorder (2020). https://www.cdc.gov/ncbddd/autism/data.html. Accessed 1 May 2023

  3. Ozonoff, S., et al.: A prospective study of the emergence of early behavioral signs of autism. J. Am. Acad. Child Adolesc. Psychiatry 49(3), 256–266 (2010)

    Google Scholar 

  4. Amaral, M.E.A., et al.: The structural neuroimaging of autism spectrum disorder: a systematic review and meta-analysis. Front. Psychiatry 11, 565164 (2020)

    Google Scholar 

  5. Deshpande, G., Libero, L.E., Sreenivasan, K.R., Deshpande, H.D., Kana, R.K.: Identification of neural connectivity signatures of autism using machine learning. Front. Hum. Neurosci. 7, 670 (2013)

    Article  Google Scholar 

  6. Bone, D., Bishop, S.L., Black, M.P., Goodwin, M.S., Lord, C., Narayanan, S.S.: Use of machine learning to improve autism screening and diagnostic instruments: effectiveness, efficiency, and multi-instrument fusion. J. Child Psychol. Psychiatry 57(8), 927–937 (2016)

    Article  Google Scholar 

  7. LeCun, Y., et al.: Deep learning. Nature 521, 436–444 (2015)

    Article  MathSciNet  Google Scholar 

  8. Chen, C.K.J., et al.: A support vector machine classifier for the prediction of autism spectrum disorder based on structural magnetic resonance imaging. In: 2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 934–937 (2016)

    Google Scholar 

  9. Jiao, X., et al.: Prediction of autism spectrum disorder based on eigen-connectivity patterns in functional magnetic resonance imaging. In: 2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 917–921 (2016)

    Google Scholar 

  10. Li, Y., et al.: A machine learning approach to autism spectrum disorder detection based on structural magnetic resonance imaging. In: 2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 922–927 (2016)

    Google Scholar 

  11. Mahbub, B.S., et al.: Deep learning-based identification of autism spectrum disorder using neuroimaging data. In: 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 1614–1618 (2018)

    Google Scholar 

  12. Supekar, Y., et al.: Combining MRI data and deep learning to predict autism spectrum disorder: a preliminary study. In: 2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 1144–1148 (2019)

    Google Scholar 

  13. Di Martino, A.M., et al.: The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism. Mol. Psychiatry 19(6), 659–667 (2014)

    Article  Google Scholar 

  14. Craddock, C., et al.: The neuro bureau preprocessing initiative: open sharing of preprocessed neuroimaging data and derivatives. In Neuroinformatics. Stockholm, Sweden (2013)

    Google Scholar 

  15. Gliga, A.G., et al.: A review of MRI-based autism spectrum disorder classification using machine learning techniques. In: 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 1437–1441 (2020)

    Google Scholar 

  16. Subbaraju, N., et al.: Deep learning approaches for autism spectrum disorder detection: a review of advances using neuroimaging data. In: 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 1783–1787 (2021)

    Google Scholar 

  17. Meng, C., et al.: Multi-kernel SVM based classification using temporal and spatial features in fMRI data for autism detection. In: 2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 1020–1023 (2019)

    Google Scholar 

  18. Chen, W., et al.: A multimodal deep belief network for ASD classification using temporal and spatial features from fMRI data. J. Neural Eng. 17(5), 056020 (2020)

    Google Scholar 

  19. Zhang, Y., et al.: Spatiotemporal Convolutional Neural Networks for ASD classification using fMRI data. Neurocomputing 329, 103–111 (2019)

    Article  Google Scholar 

  20. Rahman, M.M., Usman, O.L., Muniyandi, R.C., et al.: A review of machine learning methods of feature selection and classification for autism spectrum disorder. Brain Sci. 10(12), 949 (2020)

    Article  Google Scholar 

  21. Ozonoff, S., et al.: A prospective study of the emergence of early behavioral signs of autism. J. Am. Acad. Child Adolesc. Psychiatry 49(3), 256–266 (2010)

    Google Scholar 

  22. Preti, M.G., Bolton, T.A., Van De Ville, D.: The dynamic functional connectome: state-of-the-art and perspectives. Neuroimage 160, 41–54 (2017)

    Article  Google Scholar 

  23. Hochreiter, S., Schmidhuber, J.: Long short-term memory. Neural Comput. 9(8), 1735–1780 (1997)

    Article  Google Scholar 

  24. Schuster, M., Paliwal, K.K.: Bidirectional recurrent neural networks. IEEE Trans. Signal Process. 45(11), 2673–2681 (1997)

    Article  Google Scholar 

  25. Graves, A., Mohamed, A. R., Hinton, G.: Speech recognition with deep recurrent neural networks. In 2013 IEEE International Conference on Acoustics, Speech and Signal Processing, pp. 6645–6649. IEEE (2013)

    Google Scholar 

  26. Kawahara, J., et al.: BrainNetCNN: convolutional neural networks for brain networks; towards predicting neurodevelopment. Neuroimage 146, 1038–1049 (2017)

    Article  Google Scholar 

  27. Heinsfeld, A.S., Franco, A.R., Craddock, R.C., Buchweitz, A., Meneguzzi, F.: Identification of autism spectrum disorder using deep learning and the ABIDE dataset. NeuroImage Clin. 17, 16–23 (2018)

    Article  Google Scholar 

  28. Han, D., et al.: Cross-modality co-attention networks for visual question answering. Soft Comput. 25, 5411–5421 (2021). https://doi.org/10.1007/s00500-020-05539-7

    Article  Google Scholar 

  29. Cortes, C., Vapnik, V.: Support-vector networks. Mach. Learn. 20(3), 273–297 (1995)

    Article  MATH  Google Scholar 

  30. Vapnik, V.N.: The Nature of Statistical Learning Theory. Springer (2013)

    Google Scholar 

  31. Hutchison, R.M., Womelsdorf, T., Allen, E.A., et al.: Dynamic functional connectivity: promise, issues, and interpretations. Neuroimage 80, 360–378 (2013)

    Article  Google Scholar 

  32. Li, X., Dvornek, N.C., Zhou, Y., Zhuang, J., Ventola, P., Duncan, J.S.: Graph neural network for interpreting task-fMRI biomarkers. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11768, pp. 485–493. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32254-0_54

    Chapter  Google Scholar 

  33. Heinsfeld, A.S., Franco, A.R., Craddock, R.C., Buchweitz, A., Meneguzzi, F.: Identification of autism spectrum disorder using deep learning and the abide dataset. NeuroImage Clin. 17, 16–23 (2018)

    Article  Google Scholar 

  34. Dvornek, N.C., Ventola, P., Pelphrey, K.A., Duncan, J.S.: Identifying autism from resting-state fMRI using long short-term memory networks. In: Wang, Q., Shi, Y., Suk, H.-I., Suzuki, K. (eds.) MLMI 2017. LNCS, vol. 10541, pp. 362–370. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-67389-9_42

    Chapter  Google Scholar 

  35. Sherkatghanad, Z., et al.: Automated detection of autism spectrum disorder using a convolutional neural network. Front. Neurosci. 13, 1325 (2020)

    Article  Google Scholar 

  36. Eslami, T., Mirjalili, V., Fong, A., Laird, A.R., Saeed, F.: ASD-DiagNet: a hybrid learning approach for detection of autism spectrum disorder using fMRI data. Front. Neuroinform. 13, 70 (2019)

    Article  Google Scholar 

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Acknowledgement

This work is supported in part by the R &D Program of Beijing Municipal Education Commission KM202310005026.

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Correspondence to Yin Liang .

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Zhou, Z., Huang, Y., Wang, Y., Liang, Y. (2024). STFM: Enhancing Autism Spectrum Disorder Classification Through Ensemble Learning-Based Fusion of Temporal and Spatial fMRI Patterns. In: Liu, F., Sadanandan, A.A., Pham, D.N., Mursanto, P., Lukose, D. (eds) PRICAI 2023: Trends in Artificial Intelligence. PRICAI 2023. Lecture Notes in Computer Science(), vol 14327. Springer, Singapore. https://doi.org/10.1007/978-981-99-7025-4_35

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  • DOI: https://doi.org/10.1007/978-981-99-7025-4_35

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  • Online ISBN: 978-981-99-7025-4

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