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RPUC: Semi-supervised 3D Biomedical Image Segmentation Through Rectified Pyramid Unsupervised Consistency

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Neural Information Processing (ICONIP 2023)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 14449))

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Abstract

Deep learning models have demonstrated remarkable performance in various biomedical image segmentation tasks. However, their reliance on a large amount of labeled data for training poses challenges as acquiring well-annotated data is expensive and time-consuming. To address this issue, semi-supervised learning (SSL) has emerged as a potential solution to leverage abundant unlabeled data. In this paper, we propose a simple yet effective consistency regularization scheme called Rectified Pyramid Unsupervised Consistency (RPUC) for semi-supervised 3D biomedical image segmentation. Our RPUC adopts a pyramid-like structure by incorporating three segmentation networks. To fully exploit the available unlabeled data, we introduce a novel pyramid unsupervised consistency (PUC) loss, which enforces consistency among the outputs of the three segmentation models and facilitates the transfer of cyclic knowledge. Additionally, we perturb the inputs of the three networks with varying ratios of Gaussian noise to enhance the consistency of unlabeled data outputs. Furthermore, three pseudo labels are generated from the outputs of the three segmentation networks, providing additional supervision during training. Experimental results demonstrate that our proposed RPUC achieves state-of-the-art performance in semi-supervised segmentation on two publicly available 3D biomedical image datasets.

This work was partially supported by the National Natural Science Foundation of China under Grants 62171133.

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References

  1. Chen, X., Yuan, Y., Zeng, G., Wang, J.: Semi-supervised semantic segmentation with cross pseudo supervision. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 2613–2622 (2021)

    Google Scholar 

  2. Fountas, K., Kapsalaki, E.Z.: Epilepsy Surgery and Intrinsic Brain Tumor Surgery. Springer, Cham (2019). https://doi.org/10.1007/978-3-319-95918-4

  3. Gao, F., et al.: Segmentation only uses sparse annotations: unified weakly and semi-supervised learning in medical images. Med. Image Anal. 80, 102515 (2022)

    Article  Google Scholar 

  4. Laine, S., Aila, T.: Temporal ensembling for semi-supervised learning. arXiv preprint arXiv:1610.02242 (2016)

  5. Lin, X., et al.: A super-resolution guided network for improving automated thyroid nodule segmentation. Comput. Methods Programs Biomed. 227, 107186 (2022)

    Article  Google Scholar 

  6. Luo, X., Chen, J., Song, T., Wang, G.: Semi-supervised medical image segmentation through dual-task consistency. In: Proceedings of the AAAI Conference on Artificial Intelligence, vol. 35, pp. 8801–8809 (2021)

    Google Scholar 

  7. Menze, B.H., et al.: The multimodal brain tumor image segmentation benchmark (Brats). IEEE Trans. Med. Imaging 34(10), 1993–2024 (2014)

    Article  Google Scholar 

  8. Milletari, F., Navab, N., Ahmadi, S.A.: V-net: fully convolutional neural networks for volumetric medical image segmentation. In: 2016 Fourth International Conference on 3D Vision (3DV), pp. 565–571. IEEE (2016)

    Google Scholar 

  9. Nie, X., et al.: N-net: a novel dense fully convolutional neural network for thyroid nodule segmentation. Front. Neurosci. 16, 872601 (2022)

    Article  Google Scholar 

  10. Njoku, A., et al.: Left atrial volume predicts atrial fibrillation recurrence after radiofrequency ablation: a meta-analysis. EP Europace 20(1), 33–42 (2018)

    Article  Google Scholar 

  11. Tarvainen, A., Valpola, H.: Mean teachers are better role models: weight-averaged consistency targets improve semi-supervised deep learning results. In: Advances in Neural Information Processing Systems, vol. 30 (2017)

    Google Scholar 

  12. Vu, T.H., Jain, H., Bucher, M., Cord, M., Pérez, P.: Advent: adversarial entropy minimization for domain adaptation in semantic segmentation. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 2517–2526 (2019)

    Google Scholar 

  13. Xiong, Z., et al.: A global benchmark of algorithms for segmenting the left atrium from late gadolinium-enhanced cardiac magnetic resonance imaging. Med. Image Anal. 67, 101832 (2021)

    Article  Google Scholar 

  14. Yu, L., Wang, S., Li, X., Fu, C.-W., Heng, P.-A.: Uncertainty-aware self-ensembling model for semi-supervised 3D left atrium segmentation. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11765, pp. 605–613. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32245-8_67

    Chapter  Google Scholar 

  15. Zhang, Y., Yang, L., Chen, J., Fredericksen, M., Hughes, D.P., Chen, D.Z.: Deep adversarial networks for biomedical image segmentation utilizing unannotated images. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10435, pp. 408–416. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66179-7_47

    Chapter  Google Scholar 

  16. Zheng, H., Zhou, X., Li, J., Gao, Q., Tong, T.: White blood cell segmentation based on visual attention mechanism and model fitting. In: 2020 International Conference on Computer Engineering and Intelligent Control (ICCEIC), pp. 47–50. IEEE (2020)

    Google Scholar 

  17. Zhou, X., Li, Z., Tong, T.: DTSC-net: semi-supervised 3d biomedical image segmentation through dual-teacher simplified consistency. In: 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 1429–1434. IEEE (2022)

    Google Scholar 

  18. Zhou, X., Li, Z., Tong, T.: DM-Net: a dual-model network for automated biomedical image diagnosis. In: Tang, H. (eds.) Research in Computational Molecular Biology. RECOMB 2023. LNCS, vol. 13976, pp. 74–84. Springer, Cham (2023). https://doi.org/10.1007/978-3-031-29119-7_5

  19. Zhou, X., et al.: CUSS-net: a cascaded unsupervised-based strategy and supervised network for biomedical image diagnosis and segmentation. IEEE J. Biomed. Health Inform. (2023)

    Google Scholar 

  20. Zhou, X., et al.: Leukocyte image segmentation based on adaptive histogram thresholding and contour detection. Curr. Bioinform. 15(3), 187–195 (2020)

    Article  MathSciNet  Google Scholar 

  21. Zhou, X., et al.: H-net: a dual-decoder enhanced FCNN for automated biomedical image diagnosis. Inf. Sci. 613, 575–590 (2022)

    Article  Google Scholar 

  22. Zhou, X., Tong, T., Zhong, Z., Fan, H., Li, Z.: Saliency-CCE: exploiting colour contextual extractor and saliency-based biomedical image segmentation. Compute. Biol. Med. 106551 (2023)

    Google Scholar 

  23. Zhou, X., Wang, C., Li, Z., Zhang, F.: Adaptive histogram thresholding-based leukocyte image segmentation. In: Pan, J.-S., Li, J., Tsai, P.-W., Jain, L.C. (eds.) Advances in Intelligent Information Hiding and Multimedia Signal Processing. SIST, vol. 157, pp. 451–459. Springer, Singapore (2020). https://doi.org/10.1007/978-981-13-9710-3_47

    Chapter  Google Scholar 

  24. Zhuang, X., Li, Y., Hu, Y., Ma, K., Yang, Y., Zheng, Y.: Self-supervised feature learning for 3D medical images by playing a Rubik’s cube. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11767, pp. 420–428. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32251-9_46

    Chapter  Google Scholar 

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Zhou, X., Li, Z., Tong, T. (2024). RPUC: Semi-supervised 3D Biomedical Image Segmentation Through Rectified Pyramid Unsupervised Consistency. In: Luo, B., Cheng, L., Wu, ZG., Li, H., Li, C. (eds) Neural Information Processing. ICONIP 2023. Lecture Notes in Computer Science, vol 14449. Springer, Singapore. https://doi.org/10.1007/978-981-99-8067-3_25

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  • DOI: https://doi.org/10.1007/978-981-99-8067-3_25

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  • Online ISBN: 978-981-99-8067-3

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