Skip to main content

Segment Anything Model for Semi-supervised Medical Image Segmentation via Selecting Reliable Pseudo-labels

  • Conference paper
  • First Online:
Neural Information Processing (ICONIP 2023)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 1964))

Included in the following conference series:

  • 583 Accesses

Abstract

Semi-supervised learning (SSL) has become a hot topic due to its less dependence on annotated data compared to fully supervised methods. This advantage becomes more evident in the field of medical imaging, where acquiring labeled data is challenging. Generating pseudo-labels for unlabeled images is one of the most classic and intuitive methods in semi-supervised segmentation. However, this method may also produce unreliable pseudo-labels that can provide incorrect guidance to the model and impair its performance. The reliability of pseudo-labels is difficult to evaluate due to the lack of ground truth labels for unlabeled images. In this paper, a SSL framework was presented, in which we proposed a simple but effective strategy to select reliable pseudo-labels by leveraging the Segment Anything Model (SAM) for segmentation. Concretely, the SSL model trained with domain knowledge provides the generated pseudo-labels as prompts to the SAM. Reliable pseudo-labels usually make SAM to conduct predictions consistent with the semi-supervised segmentation model. Based on this result, the reliable pseudo-labels are selected to further boost the existing semi-supervised learning methods. The experimental results show that the proposed strategy effectively improves the performance of different algorithms in the semi-supervised scenarios. On the publicly available ACDC dataset, the proposed method achieves 6.84% and 10.76% improvement over the advanced two baselines respectively on 5% of labeled data. The extended experiments on pseudo-labels verified that the quality of the selected reliable pseudo-labels by the proposed strategy is superior to that of the unreliable pseudo-labels. This study may provide a new avenue for SSL medical image segmentation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bai, W., et al.: Semi-supervised learning for network-based cardiac MR image segmentation. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017, Part II. LNCS, vol. 10434, pp. 253–260. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66185-8_29

    Chapter  Google Scholar 

  2. Cao, H., et al.: Swin-Unet: Unet-like pure transformer for medical image segmentation. In: Karlinsky, L., Michaeli, T., Nishino, K. (eds.) Computer Vision, ECCV 2022 Workshops, Proceedings, Part III, Tel Aviv, Israel, 23–27 October 2022, vol. 13803, pp. 205–218. Springer, Cham (2023). https://doi.org/10.1007/978-3-031-25066-8_9

  3. Chen, X., Yuan, Y., Zeng, G., Wang, J.: Semi-supervised semantic segmentation with cross pseudo supervision. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 2613–2622 (2021)

    Google Scholar 

  4. Cui, W., et al.: Semi-supervised brain lesion segmentation with an adapted mean teacher model. In: Chung, A.C.S., Gee, J.C., Yushkevich, P.A., Bao, S. (eds.) IPMI 2019. LNCS, vol. 11492, pp. 554–565. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-20351-1_43

    Chapter  Google Scholar 

  5. Han, K., et al.: An effective semi-supervised approach for liver CT image segmentation. IEEE J. Biomed. Health Inform. 26(8), 3999–4007 (2022)

    Article  Google Scholar 

  6. Hang, W., et al.: Local and global structure-aware entropy regularized mean teacher model for 3D left atrium segmentation. In: Martel, A.L., et al. (eds.) MICCAI 2020. LNCS, vol. 12261, pp. 562–571. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-59710-8_55

    Chapter  Google Scholar 

  7. Hu, C., Li, X.: When SAM meets medical images: an investigation of segment anything model (SAM) on multi-phase liver tumor segmentation. arXiv preprint arXiv:2304.08506 (2023)

  8. Isensee, F., Jaeger, P.F., Kohl, S.A., Petersen, J., Maier-Hein, K.H.: nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation. Nat. Meth. 18(2), 203–211 (2021)

    Article  Google Scholar 

  9. Jiao, R., Zhang, Y., Ding, L., Cai, R., Zhang, J.: Learning with limited annotations: a survey on deep semi-supervised learning for medical image segmentation. arXiv preprint arXiv:2207.14191 (2022)

  10. Kirillov, A., et al.: Segment anything. arXiv preprint arXiv:2304.02643 (2023)

  11. Lee, D.H., et al.: Pseudo-label: the simple and efficient semi-supervised learning method for deep neural networks. In: Workshop on Challenges in Representation Learning, ICML, vol. 3, p. 896 (2013)

    Google Scholar 

  12. Liu, Y., Tian, Y., Chen, Y., Liu, F., Belagiannis, V., Carneiro, G.: Perturbed and strict mean teachers for semi-supervised semantic segmentation. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 4258–4267 (2022)

    Google Scholar 

  13. Luo, X., Chen, J., Song, T., Wang, G.: Semi-supervised medical image segmentation through dual-task consistency. In: Proceedings of the AAAI Conference on Artificial Intelligence, vol. 35, pp. 8801–8809 (2021)

    Google Scholar 

  14. Luo, X., Hu, M., Song, T., Wang, G., Zhang, S.: Semi-supervised medical image segmentation via cross teaching between CNN and transformer. In: International Conference on Medical Imaging with Deep Learning, pp. 820–833. PMLR (2022)

    Google Scholar 

  15. Luo, X., et al.: Efficient semi-supervised gross target volume of nasopharyngeal carcinoma segmentation via uncertainty rectified pyramid consistency. In: de Bruijne, M., et al. (eds.) MICCAI 2021. LNCS, vol. 12902, pp. 318–329. Springer, Cham (2021). https://doi.org/10.1007/978-3-030-87196-3_30

    Chapter  Google Scholar 

  16. Luo, X., et al.: MIDeepSeg: minimally interactive segmentation of unseen objects from medical images using deep learning. Med. Image Anal. 72, 102102 (2021)

    Article  Google Scholar 

  17. Ma, J., Wang, B.: Segment anything in medical images. arXiv preprint arXiv:2304.12306 (2023)

  18. OpenAI: GPT-4 technical report (2023)

    Google Scholar 

  19. Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015, Part III. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28

    Chapter  Google Scholar 

  20. Roy, S., et al.: SAM.MD: zero-shot medical image segmentation capabilities of the segment anything model. arXiv preprint arXiv:2304.05396 (2023)

  21. Sohn, K., et al: FixMatch: simplifying semi-supervised learning with consistency and confidence. In: Advances in Neural Information Processing Systems, vol. 33, pp. 596–608 (2020)

    Google Scholar 

  22. Tarvainen, A., Valpola, H.: Mean teachers are better role models: weight-averaged consistency targets improve semi-supervised deep learning results. In: Advances in Neural Information Processing Systems, vol. 30 (2017)

    Google Scholar 

  23. Wang, G., et al.: DeepIGeoS: a deep interactive geodesic framework for medical image segmentation. IEEE Trans. Pattern Anal. Mach. Intell. 41(7), 1559–1572 (2018)

    Article  Google Scholar 

  24. Wu, J., et al.: Medical SAM adapter: adapting segment anything model for medical image segmentation. arXiv preprint arXiv:2304.12620 (2023)

  25. Wu, Y., Wu, Z., Wu, Q., Ge, Z., Cai, J.: Exploring smoothness and class-separation for semi-supervised medical image segmentation. In: Wang, L., Dou, Q., Fletcher, P.T., Speidel, S., Li, S. (eds.) Proceedings of the 25th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2022, Part V, Singapore, 18–22 September 2022, pp. 34–43. Springer, Cham (2022). https://doi.org/10.1007/978-3-031-16443-9_4

  26. Xu, Z., et al.: All-around real label supervision: cyclic prototype consistency learning for semi-supervised medical image segmentation. IEEE J. Biomed. Health Inf. 26(7), 3174–3184 (2022)

    Article  MathSciNet  Google Scholar 

  27. Yang, L., Zhuo, W., Qi, L., Shi, Y., Gao, Y.: St++: make self-training work better for semi-supervised semantic segmentation. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 4268–4277 (2022)

    Google Scholar 

  28. Yu, L., Wang, S., Li, X., Fu, C.-W., Heng, P.-A.: Uncertainty-aware self-ensembling model for semi-supervised 3D left atrium segmentation. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11765, pp. 605–613. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32245-8_67

    Chapter  Google Scholar 

  29. Yu, Q., Xie, L., Wang, Y., Zhou, Y., Fishman, E.K., Yuille, A.L.: Recurrent saliency transformation network: incorporating multi-stage visual cues for small organ segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 8280–8289 (2018)

    Google Scholar 

Download references

Acknowledgement

This work was supported in part by the National Natural Science Foundation of China under Grant No. 62076209.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yangsong Zhang .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2024 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Li, N., Xiong, L., Qiu, W., Pan, Y., Luo, Y., Zhang, Y. (2024). Segment Anything Model for Semi-supervised Medical Image Segmentation via Selecting Reliable Pseudo-labels. In: Luo, B., Cheng, L., Wu, ZG., Li, H., Li, C. (eds) Neural Information Processing. ICONIP 2023. Communications in Computer and Information Science, vol 1964. Springer, Singapore. https://doi.org/10.1007/978-981-99-8141-0_11

Download citation

  • DOI: https://doi.org/10.1007/978-981-99-8141-0_11

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-8140-3

  • Online ISBN: 978-981-99-8141-0

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics