Summary
Modelling studies have been carried out on the phosphodiesterase (PDE) substrates, adenosine- and guanosine-3′5′-cyclic monophosphates, and on a number of non-specific and type III-specific phosphodiesterase inhibitors. These studies have assisted the understanding of PDE substrate differentiation and the design of potent, selective PDE type III inhibitors.
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Davis, A., Warrington, B.H. & Vinter, J.G. Strategic approaches to drug design. II. Modelling studies on phosphodiesterase substrates and inhibitors. J Computer-Aided Mol Des 1, 97–119 (1987). https://doi.org/10.1007/BF01676955
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DOI: https://doi.org/10.1007/BF01676955