Abstract
A gene-expression model for an E-CELL simulation was constructed, and the simulation was carried out. The model was integrated with a metabolism model of the self-sustaining virtual cell model which was constructed based on aMycoplasma genitalium cell. Details of the model structure and the results of the simulation are shown. AnEscherichia coli lac-operon model was also constructed by integrating and abstracting the gene-expression model. Wherever possible, experimental parameters were used to construct the model
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Hashimoto, K., Seno, S., Dhar, P.K. et al. Integrative modeling of gene expression and metabolism with E-CELL System. Artif Life Robotics 6, 99–107 (2002). https://doi.org/10.1007/BF02481322
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DOI: https://doi.org/10.1007/BF02481322