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Quasi-real time bio—Tissues monitoring using dynamic laser speckle photography

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Joint development of a laser monitor for the real-time bio-tissue analysis is presented. The monitor is based on the digital dynamic laser speckle photography and deals with soft and hard bio-tissues. In soft tissues, the dynamic bio-speckles are formed in a scattered from a tissue laser light. An optically transparent model of hard bio-tissue was prepared and preliminary analysis of a stress field in the stressed model was performed using the dependence of the refractive index of transparent solids upon the state of stress and the double exposure speckle photography data. The refractive index of the stressed material was evaluated and the state of stress was reconstructed using the stress-optical law.

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Kazuyoshi Takayama: He received his M.Sc.(Eng.) degree in Mechanical Engineering in 1965 from Nagoya Institute of Technology. He also received his Doctor Degree in Mechanical Engineering in 1970 from Tohoku University. He works in Interdisciplinary Shock Wave Research Laboratory as a professor. SWRL is recently accepted as the Center of Excellence (COE) research, entitled Investigation of Shock Wave Phenomena in Complex Media and its Interdisciplinary Applications. He is President of Japan Society for Aeronautical and Space Sciences and Chairman of the Aeroballistic Rang Association. He has been a member of International Advisory Committee for International Shock Wave Symposium since 1983 and a chairman of Japanese Shock Wave Research. He is an associate editor of Shock Wave International Journal.

Nikita Fomin: He received the Doctoral degrees in physics and mathematics, in 1978 from Institute of Physics, Minsk, and in 1986 from Institute of Problems in Mechanics, Moscow, respectively. Since 1976 he is working in the Heat & Mass Transfer Institute, Belarus. The main directions of research are physical gasdynamics and optical diagnostics. He was Invited visiting professor in University of Essen (Germany), University of Edinburgh (UK), Chiba University (Japan), Tohoku University (Japan), and University of Poitiers (France). He is a member of the Board of Directors of the Belarus Physical Society. His recent scientific interest is applications of modern optical diagnostics for bioflows.

Elena Lavinskaya: She graduated from Belarusian State University, the Department of Mechanics and Mathematics, in 1982. Since 1982 she has been working in the Heat & Mass Transfer Institute, since 2001 as a senior scientist. In 2000, she received the Ph.D. degree in Physics and Mathematics. She was visiting researcher in University of Essen (Germany), University of Edinburgh (UK), Tohoku University (Japan). Her recent scientific interest is focused on new optical diagnostics based on speckle photography and speckle tomography, diagnostics of high temperature thermophysical processes, turbulent flows investigations.

Toshiharu Mizukaki: He graduated from Science University of Tokyo in 1991. He worked in Power reactor and Nuclear Fuel Development Corporation (PNC) as a research fellow until 1999. His research topic was laser isotope separation. He received the Doctoral degree in Aerospace Engineering in 2001 from Tohoku University. He was also visiting researcher in NASA Langrey Research Center in 2001. Since 2002, he is working in Technical Research and Development Institute (TRDI) of Japan Defense Agency. His recent scientific interest is focused on advanced measurement techniques for ballistics research.

Atsuhiro Nakagawa: He has graduated from Tohoku University Medical School in 1998, and trained as neurosurgeon from 1998 to 2001 as resident. He has been engaged in application of shock waves for treatment modality in neurosurgical procedure from 2001 to 2003. He is also studying visualization techniques for surface blood flow using far infrared rays for intraoperative monitoring in neurosurgical procedure.

Takayuki Hirano: Dr. Hirano have graduated from Tohoku University Medical School in 1996, and trained as general surgeon from 1996 to 1999, and as neurosurgeon from 1998 to 1999 as resident. He has been engaged in application of Ho: YAG laser-induced liquid jet used for the enhancement of fibrinolytics for the treatment of cerebral embolism since 2001.

Sergei Rubnikovich: He graduated from the Dentistry Department of the Belarus State Medical University in 1996. In 1996–1998 he had clinical internship at the Department of Surgical and Orthopedic Dentistry of Belarusian State Institute of Post-Graduate Education for Doctors. Since 1998 he has been working as an associative professor at the Department of Orthopedic Dentistry of Belarusian State Medical University. In 2002, he got his Ph.D degree in Medical sciences. His recent research is connected with applications of optical method of digital speckle photography and mathematical modeling in dentistry.

Nikolai Bazylev: He graduated from Belarusian State University, the Department of Radiophysics and Electronics, in 1998. Since 1998 he has been working in the Heat & Mass Transfer Institute as a junior scientist. At the present time he is preparing the PhD thesis on the subject “Speckle photography in biomedical flows”. His recent scientific interests are new experimental methods of diagnostics based on digital speckle photography, experimental investigations of heat & mass transfer processes in living tissues and computerized methods of image analysis. Since 2002 he is a member of the Belarus Physical Society.

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Bazylev, N., Fomin, N., Hirano, T. et al. Quasi-real time bio—Tissues monitoring using dynamic laser speckle photography. J Vis 6, 371–380 (2003). https://doi.org/10.1007/BF03181744

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