Abstract
We have developed a technique to reconstruct 3-D microstructures from serial histologic section, and demonstrated the robustness of the method on microvessels associated with prostate cancer and bile ducts in liver specimens. The method is critically based on image coregistration techniques, particularly two dimensional surface matching between extracted image features. The reconstruction paradigm allows 3-D regions of information in several locations throughout a block of tissue to be obtained at different magnifications while maintaining proper spatial relationship to the original data. The reconstructed objects have a generally unmapped and unknown topography. Visualizing anatomic microstructures in 3-D and analyzing their topography will help physicians to better understand and correctly interpret changes in disease.
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References
Garnick MB, “The dilemmas of prostate cancer”, Scientific American, pp 72–81, April 1994.
Brawer MK, Deering RE, Brown M, Preston SD, Biglor SA, “Predictors of pathologic stage in prostatic carcinoma: The role of neovascularity”, Cancer, vol 73(3), pp 678–687, 1994.
McNeal JE, Bostwick DG, Kindrachuk RA, Redwine EA, Freiha FS, Starney RA, “Patterns of progression in prostate cancer”, Lancet, vol I, pp 60–63, 1986.
Weidner N, Carroll PR, Flax J, Blumenfeld W, Folkman J, “Tumor angiogenesis correlates with invasive prostate cancer”, Am J Path, vol 143(2), pp 401–409, 1993.
Fidler IJ, Ellis LM, “The implications of angiogenesis for the biology and therapy of cancer metastasis”, Cell, vol 79, pp 185–188, 1994.
Siegal JA, Yu E, Brawer MK, “Topography of Neovascularity in Human prostate carcinoma” Cancer, vol 75, pp 2545–2551, 1994.
Kreite A., ed., Visualization in Biomedical Microscopies: 3-D Imaging and Computer Applications, VCH, 1992.
Salisbury JR, Whimster WF, “Progress in computer-generated three-dimensional reconstruction” Journal of Pathology, vol. 170, pp 223–227, 1993
Rydmark M, Jansson T, Berthold C.-H., Gustavsson T, “Computer Assisted realignment of light micrograph images from consecutive sections series of cat cerebral cortex”, Journal of Microscopy, vol. 165, pp 29–47, 1992.
Jiang HJ, Robb RA, Holton KS, “A new approach to 3-D registration of multi-modality medical images by surface matching”, Proceeding of Visualization in Biomedical Computing, vol 2, 1992.
Robb RA, Hanson DP, Karwoski RA, Larson AG, Workman EL, Stacy MC, ANALYZE™: A comprehensive, operator-interactive software package for multidimensional medical image display and analysis, Computerized Medical Imaging and Graphics, vol 13(6), pp 433–454, 1989.
Kay PA, Robb RA, Bostwick DG, Leske DA, Camp JJ, Three-dimensional visualization of microvessels in prostate cancer, SPIE Proceeding of Medical Imaging 1995, San Diego, CA, Feb. 1995.
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© 1996 Springer-Verlag Berlin Heidelberg
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Kay, P.A., Robb, R.A., Bostwick, D.G., Camp, J.J. (1996). Robust 3-D reconstruction and analysis of microstructures from serial histologic sections, with emphasis on microvessels in prostate cancer. In: Höhne, K.H., Kikinis, R. (eds) Visualization in Biomedical Computing. VBC 1996. Lecture Notes in Computer Science, vol 1131. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0046946
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DOI: https://doi.org/10.1007/BFb0046946
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