Abstract
Enlarged cerebral ventricles are consistently detected in patients suffering from schizophrenia. Several workers report more detailed association of this disease and particular brain areas. In order to assist these efforts at localization we define a tiled-out map of the ventricular surface, a template, based on specialized crest lines that we term: ridge curves. In this analysis we use this template to (1) average 3D MR-based ventricular surface images collected from 12 patients and 12 controls, and (2) locate the position of regularly occurring curvature maxima landmarks along the ridge curves. Statistical analysis of the locations of these curvature maxima landmarks indicate promising localization of a shape difference associated with schizophrenia in the frontal horn of the lateral cerebral ventricle.
Preview
Unable to display preview. Download preview PDF.
References
Andreasen, N., Ehrhardt, J., Swayze, V., Alliger, R., Yuh, T., Cohen, G., Ziebell, S.: Magnetic resonance imaging of the brain in schizophrenia — The pathophysiologic significance of structural abnormalities. Arch. Gen. Psych. 47 (1990) 35–44
Bookstein, F.: Biometrics, biomathematics, and the morphometric synthesis. Bull. Math. Biol. 58 (1996) 313–365
Bookstein, F.: How to produce a landmark point: the statistical geometry of incompletely registered images. SPIE 2573 (1995) 266–277
Bookstein, F.: Morphometric Tools for Landmark Data: Geometry and Biology. Cambridge: Cambridge University Press (1991)
Bookstein, F., Cutting, C.: A proposal for the apprehension of curving craniofacial form in three dimensions. In (K. Vig, A. Burdi, eds.): Craniofacial Morphogenesis and Dysmorphogenesis. Ann Arbor, MI: Center for Human Growth and Development. (1988) 127–140
Bookstein, F., Green, W.: A feature space for edges in images with landmarks. J. Math. Img. & Vis. 3 (1993) 231–261
Cannon, T., Marco, E.: Structural brain abnormalities as indicators of vulnerability to schizophrenia. Schiz. Bull. 20 (1994) 89–102
Choh, B., McKenna, P.: Schizophrenia as a brain disease. Br. J. Psych. 167 (1995) 183–94
Cutting, C., Bookstein, F., Haddad, B., Dean, D., Kim, D.: A spline-based approach for averaging three-dimensional curves and surfaces. SPIE 2035 (1993) 29–44
Cutting, C., Dean, D., Bookstein, F., Haddad, B., Khorramabadi, D., Zonneveld, F.: A three dimensional smooth surface analysis of untreated Crouzon's disease in the adult. J. Craniofac. Surg. 6 (1995) 444–453
DeGreef, G., Ashtari, M., Bogerts, B., Bilder, R., Jodi, D., Alvir, J., Lieberman, J.: Volumes of ventricular system subdivisions measured from magnetic resonance imaging in first-episode schizophrenic patients. Arch. Gen. Psych. 49 (1992) 531–537
Guéziec, A., Dean, D.: The Wrapper: A surface optimization algorithm that preserves highly curved areas. SPIE 2359 (1994) 631–642
Gur, R., Pearlson, G.: Neuroimaging in schizophrenia research [Review]. Schiz. Bull. 19 (1993) 337–353
Johnstone, E., Bruton, C., Crow, T., Frith, C., Owens, D.: Clinical correlates of postmortem brain changes in schizophrenia: decreased brain weight and length correlate with indices of early impairment. J. Neurol., Neurosurg., and Psych. 57 (1994) 474–479
Kalvin, A., Cutting, C., Haddad, B., Noz, M.: Constructing topologically connected surfaces for the comprehensive analysis of 3D medical structures. SPIE 1445 (1991) 247–258
Kent, J., Mardia, K., West, J.: (in press) Ridge curves and shape analysis. Proc. 1996 Brit. Mach. Vis. Conf.
Rohlf, F.: Rotational fit (Procrustes) methods. In (F. Rohlf, F. Bookstein, eds.) Proceedings of the Michigan Morphometrics Workshop. Ann Arbor, MI: Spec. Pub. 2 Univ. MI Mus. Zool. (1989) 227–236
Rohlf, F., Slice, D.: Extensions of the Procrustes method for optimal superimposition of landmarks, Syst. Zool. 39 (1990) 40–59
Serban, G., George, A., Siegel, S., DeLeon, M., Gaffney, M.: Computed tomography scans and negative symptoms in schizophrenia: chronic schizophrenics with negative symptoms and non-enlarged lateral ventricles. Acta Psych. Scand. 81 (1990) 441–447
Shiraishi, H., Koizumi, J., Ofuku, K., Suzuki, T., Saito, K., Hori, T., Ikuta, T., Kase, K., Hori, M.: Enlargement of the anterior horn of the lateral ventricle in schizophrenic patients: chronological and morphometric studies. Jap. J. Psych. & Neurol. 44 (1990) 693–702
Thirion, J.: The extremal mesh and the understanding of 3D surfaces. Proceedings of the IEEE Workshop on Biomedical Image Analysis. Los Alamitos, CA: Computer Society Press (1994) 3–12
Thirion, J., Subsol, G., Dean, D.: Proposal for the Cross Validation of Three Inter-Patients Matching Methods. (this volume)
Van Horn, J., McManus, I.: Ventricular enlargement in schizophrenia — A meta-analysis of studies of the ventricular-brain ratio (VBR). Brit. J. Psych. 160 (1992) 687–697
Waddington, J., Buckley, P.: The Neurodevelopmental Basis of Schizophrenia. Austin, Texas: Landes Publications (in press)
Wible, C., Shenton, M., Hokama, H., Kikinis, R., Jolesz, F., Metcalf, D., McCarley, R.: Prefrontal cortex and schizophrenia. Arch. Gen. Psych. 52 (1995) 279–288
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Dean, D. et al. (1996). Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles. In: Höhne, K.H., Kikinis, R. (eds) Visualization in Biomedical Computing. VBC 1996. Lecture Notes in Computer Science, vol 1131. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0046975
Download citation
DOI: https://doi.org/10.1007/BFb0046975
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-61649-8
Online ISBN: 978-3-540-70739-4
eBook Packages: Springer Book Archive