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Assessing patterns and rates of brain atrophy by serial magnetic resonance imaging: A segmentation, registration, display and quantification procedure

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Visualization in Biomedical Computing (VBC 1996)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 1131))

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Abstract

We describe a new procedure for assessing rates of brain atrophy by registration of serial 3D MRI incorporating interactive methods for the accurate identification of neuroanatomical structures which are then used in an automated registration procedure to compensate for voxel dimension and intensity inconsistencies. Original methods for visualising and quantifying rates of atrophy are described. In 11 subjects with Alzheimer's disease characteristic patterns of atrophy were seen and rates of atrophy were significantly greater (p<0.001) than in 11 age matched controls.

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Bibliography

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Author information

Authors and Affiliations

  1. Dementia Research Group, The National Hospital, Queen Square, WC1 3BG, London, UK

    P. A. Freeborough & N. C. Fox

  2. Imperial College of Science, Technology and Medicine, W2 1PG, London

    P. A. Freeborough & N. C. Fox

Authors
  1. P. A. Freeborough
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  2. N. C. Fox
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Editor information

Karl Heinz Höhne Ron Kikinis

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© 1996 Springer-Verlag Berlin Heidelberg

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Freeborough, P.A., Fox, N.C. (1996). Assessing patterns and rates of brain atrophy by serial magnetic resonance imaging: A segmentation, registration, display and quantification procedure. In: Höhne, K.H., Kikinis, R. (eds) Visualization in Biomedical Computing. VBC 1996. Lecture Notes in Computer Science, vol 1131. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0046982

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  • DOI: https://doi.org/10.1007/BFb0046982

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61649-8

  • Online ISBN: 978-3-540-70739-4

  • eBook Packages: Springer Book Archive

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