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High-Accuracy Impedance Read-out Circuit for BIA-type Biomedical Sensors

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Abstract

An impedance read-out circuit with high accuracy implemented using a TSMC 0.18 um mixed-signal CMOS process for BIA-type (bio-electrical impedance analysis) sensors to detect biomarkers is proposed in this investigation. In addition to proposing the impedance estimation circuit, the associated analytic proof is also disclosed. Using a high-order approximation model and high noise rejection capability by the addition of OPAs (operational amplifiers), the proposed system demonstrates a solution with high accuracy in terms of the maximum impedance error (\(\mathrm<\) 6 %) and the least phase error (\(\mathrm < \) 3\({^\circ }\)) in a frequency range from 1 kHz to 2 MHz.

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Acknowledgements

This work was partially supported by the Ministry of Science and Technology (MOST), Taiwan, under Grants MOST 109-2224-E-110-001- and MOST 109-2218-E-110-007-. Also, this work was also partially supported by the Ministry of Economic Affairs, Taiwan, under Grant 107-EC-17-A-17-S3-050. The authors would like to express their deepest appreciation to the TSRI (Taiwan Semiconductor Research Institute), Taiwan, for their chip fabrication service.

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Authors and Affiliations

  1. Department of Electrical Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan

    Chua-Chin Wang, Pang-Yen Lou, Tsung-Yi Tsai, I-Yu Huang, Tzung-Je Lee & Guan-Ru Chen

  2. Institute of Undersea Technology (IUT) of NSYSU, Kaohsiung, Taiwan

    Chua-Chin Wang

  3. Department of Engineering Science, National Cheng Kung University, Tainan, Taiwan

    Yu-Cheng Lin

  4. Department of Computer Science and Information Engineering, Cheng Shiu University, Kaohsiung, Taiwan

    Tzung-Je Lee

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  1. Chua-Chin Wang
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Correspondence to Chua-Chin Wang or Yu-Cheng Lin.

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Wang, CC., Senior Member IEEE., Lou, PY. et al. High-Accuracy Impedance Read-out Circuit for BIA-type Biomedical Sensors. Circuits Syst Signal Process 40, 4187–4195 (2021). https://doi.org/10.1007/s00034-021-01670-4

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