Skip to main content
Log in

An approximately optimal non-parametric procedure for analyzing exchangeable binary data with random cluster sizes

  • Original Paper
  • Published:
Computational Statistics Aims and scope Submit manuscript

Abstract

For the exchangeable binary data with random cluster sizes, we develop an approximately optimal non-parametric procedure for obtaining estimates of the moments of all orders. Moreover, based on this procedure, we can also obtain efficient estimates of underlying parameters of moments of all orders. An application is made to data sets from a developmental toxicity study. Simulation results show that our procedure is valid and performs better than Bowman and George’s procedure and the pairwise likelihood procedure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Aerts M, Geys H, Molenberghs G, Ryan L (eds) (2002) Topics in modeling of clustered data. Chapman and Hall, London

    Google Scholar 

  • Bowman D, George EO (1995) A saturated model for analyzing exchangeable binary data: applications to clinical and developmental toxicity studies. J Am Stat Assoc 90:871–879

    Article  MATH  Google Scholar 

  • Bowman D, Chen JJ, George EO (1995) Estimating variance functions in developmental toxicity studies. Biometrics 51:1523–1528

    Article  MATH  Google Scholar 

  • Fitzmaurice G, Laird NM (1995) Regression models for a bivariate discrete and continuous outcome with clustering. J Am Stat Assoc 90:845–852

    Article  MathSciNet  MATH  Google Scholar 

  • George EO, Bowman D (1995) A full likelihood procedure for analysing exchangeable binary data. Biometrics 51:512–523

    Google Scholar 

  • Godambe VP, Heyde CC (1987) Quasi-likelihood and optimal estimation. Int Stat Rev 55:231–244

    Article  MathSciNet  MATH  Google Scholar 

  • Kuk AYC (2004) A litter-based approach to risk assessment in developmental toxicity studies via a power family of completely monotone functions. Appl Stat 53:369–386

    MathSciNet  MATH  Google Scholar 

  • Kuk AYC, Nott DJ (2000) A pairwise likelihood approach to analyzing correlated binary data. Stat Probab Lett 47:329–335

    Article  MATH  Google Scholar 

  • Moore DF (1986) Asymptotic properties of moment estimators for overdispersed counts and proportions. Biometrika 73:583–588

    Article  MathSciNet  MATH  Google Scholar 

  • Prentice RL (1986) Binary regression using an extended beta-binomial distribution with discussion of correlation induced by measurements. J Am Stat Assoc 81:819–829

    Article  Google Scholar 

  • Stefanescu C, Turnbull BW (2003) Likelihood inference for exchangeable binary data with varying cluster sizes. Biometrics 59:18–24

    Article  MathSciNet  MATH  Google Scholar 

  • Xu JL, Prorok PC (2003) Modelling and analysing exchangeable binary data with random cluster sizes. Stat Med 22:2401–2416

    Article  Google Scholar 

  • Yi GY, Reid N (2010) A note on mis-specified estimating functions. Statistica Sinica 20:1749–1769

    MathSciNet  MATH  Google Scholar 

  • Zhao HX, Lin JG (2012) The large sample properties of the solutions of general estimating equations. J Syst Sci Complex 25:315–328

    Google Scholar 

  • Zhao HX, Ma WQ (2009) A pairwise likelihood procedure for analyzing exchangeable binary data with random cluster sizes. Commun Stat Theor Meth 38:594–606

    Article  MathSciNet  MATH  Google Scholar 

  • Zhao LP, Prentice RL (1990) Correlated binary regression using a quadratic exponential model. Biometrika 77:642–648

    Article  MathSciNet  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jin-Guan Lin.

Additional information

The project supported by NSFC 11171065, NSFJS BK 2011058, NSFC 11201229, NSFC 11271189, China Postdoctoral Science Foundation funded project (Grant Number 2010471366) and Jiangsu Planned Projects for Postdoctoral Research Funds (Grant Number 1001068C).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhao, HX., Lin, JG. An approximately optimal non-parametric procedure for analyzing exchangeable binary data with random cluster sizes. Comput Stat 28, 2029–2047 (2013). https://doi.org/10.1007/s00180-012-0393-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00180-012-0393-2

Keywords

Navigation