Abstract
For the exchangeable binary data with random cluster sizes, we develop an approximately optimal non-parametric procedure for obtaining estimates of the moments of all orders. Moreover, based on this procedure, we can also obtain efficient estimates of underlying parameters of moments of all orders. An application is made to data sets from a developmental toxicity study. Simulation results show that our procedure is valid and performs better than Bowman and George’s procedure and the pairwise likelihood procedure.
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Aerts M, Geys H, Molenberghs G, Ryan L (eds) (2002) Topics in modeling of clustered data. Chapman and Hall, London
Bowman D, George EO (1995) A saturated model for analyzing exchangeable binary data: applications to clinical and developmental toxicity studies. J Am Stat Assoc 90:871–879
Bowman D, Chen JJ, George EO (1995) Estimating variance functions in developmental toxicity studies. Biometrics 51:1523–1528
Fitzmaurice G, Laird NM (1995) Regression models for a bivariate discrete and continuous outcome with clustering. J Am Stat Assoc 90:845–852
George EO, Bowman D (1995) A full likelihood procedure for analysing exchangeable binary data. Biometrics 51:512–523
Godambe VP, Heyde CC (1987) Quasi-likelihood and optimal estimation. Int Stat Rev 55:231–244
Kuk AYC (2004) A litter-based approach to risk assessment in developmental toxicity studies via a power family of completely monotone functions. Appl Stat 53:369–386
Kuk AYC, Nott DJ (2000) A pairwise likelihood approach to analyzing correlated binary data. Stat Probab Lett 47:329–335
Moore DF (1986) Asymptotic properties of moment estimators for overdispersed counts and proportions. Biometrika 73:583–588
Prentice RL (1986) Binary regression using an extended beta-binomial distribution with discussion of correlation induced by measurements. J Am Stat Assoc 81:819–829
Stefanescu C, Turnbull BW (2003) Likelihood inference for exchangeable binary data with varying cluster sizes. Biometrics 59:18–24
Xu JL, Prorok PC (2003) Modelling and analysing exchangeable binary data with random cluster sizes. Stat Med 22:2401–2416
Yi GY, Reid N (2010) A note on mis-specified estimating functions. Statistica Sinica 20:1749–1769
Zhao HX, Lin JG (2012) The large sample properties of the solutions of general estimating equations. J Syst Sci Complex 25:315–328
Zhao HX, Ma WQ (2009) A pairwise likelihood procedure for analyzing exchangeable binary data with random cluster sizes. Commun Stat Theor Meth 38:594–606
Zhao LP, Prentice RL (1990) Correlated binary regression using a quadratic exponential model. Biometrika 77:642–648
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The project supported by NSFC 11171065, NSFJS BK 2011058, NSFC 11201229, NSFC 11271189, China Postdoctoral Science Foundation funded project (Grant Number 2010471366) and Jiangsu Planned Projects for Postdoctoral Research Funds (Grant Number 1001068C).
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Zhao, HX., Lin, JG. An approximately optimal non-parametric procedure for analyzing exchangeable binary data with random cluster sizes. Comput Stat 28, 2029–2047 (2013). https://doi.org/10.1007/s00180-012-0393-2
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DOI: https://doi.org/10.1007/s00180-012-0393-2