Abstract.
To elucidate the mechanism of the self-organizing control of heartbeats, models that include the electrical and mechanical processes of heartbeat are proposed. As the mutual interaction between the two processes, mechano-electrical feedback (MEF), mediated by stretch-activated ionic channels, is considered. Analyses of the models show that coordination of beats among myocardial cells is established by MEF even in the absence of electrical coupling. The coordination of heartbeats is found to show in-phase synchronization under normal conditions, while it is out of phase or irregular under mechanically abnormal conditions. It is concluded that coupling by MEF is important for the self-organization of heartbeats.
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Received: 4 December 1997 / Accepted in revised form: 29 July 1998
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Hori, S., Yamaguchi, Y. & Shimizu, H. Self-organization of the heartbeat as coordination among ventricular myocardial cells through mechano-electrical feedback. Biol Cybern 80, 1–10 (1999). https://doi.org/10.1007/s004220050500
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DOI: https://doi.org/10.1007/s004220050500