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Hypoglycemia detection: multiple regression-based combinational neural logic approach

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Abstract

Hypoglycemia is a common and serious side effect of type 1 diabetes. We measure physiological parameters continuously to provide detection of hypoglycemic episodes in type 1 diabetes mellitus patients using a multiple regression-based combinational neural logic approach. In this work, a neural logic network with multiple regression is applied to the development of non-invasive hypoglycemia monitoring system. It is an alarm system which measures the physiological parameters of electrocardiogram signal (heart rate and corrected QT interval) and determine the onset of hypoglycemia by the use of proposed hybrid neural logic approach. In this clinical application, a combinational neural logic network with multiple regression is systematically designed to hypoglycemia detection based on the characteristic of this application. To optimize the parameter of the hybrid combinational neural logic system, hybrid particle swarm optimization with wavelet mutation is applied to tuned the parameters of the system. To illustrate the effectiveness of the proposed method, hypoglycemia monitoring system which will be practically analyzed using real data sets collected from 15 children (\(14.6 \pm 1.5\) years) with type 1 diabetes at the Department of Health, Government of Western Australia. With the use of proposed method, the best testing sensitivity of 79.07 % and specificity of 53.64 % were obtained.

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Acknowledgments

The authors would like to thank Dr. Nejhdeh Ghevondian, and Assoc. Prof. Timothy Jones for their contribution. This work was supported by a grant from Juvenile Diabetes Research International.

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Authors and Affiliations

  1. Faculty of Engineering and Information Technology, Centre for Health Technologies, University of Technology Sydney, 1 Broadway, Ultimo, NSW, 2007, Australia

    Sai Ho Ling & Hung T. Nguyen

  2. Data Analytics Department, Institute for Infocomm Research, Singapore, Singapore

    Phyo Phyo San

  3. Division of Engineering, King’s College London, London, UK

    Hak Keung Lam

Authors
  1. Sai Ho Ling
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  2. Phyo Phyo San
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  3. Hak Keung Lam
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  4. Hung T. Nguyen
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Correspondence to Sai Ho Ling.

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Communicated by V. Loia.

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Ling, S.H., San, P.P., Lam, H.K. et al. Hypoglycemia detection: multiple regression-based combinational neural logic approach. Soft Comput 21, 543–553 (2017). https://doi.org/10.1007/s00500-015-1809-z

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  • DOI: https://doi.org/10.1007/s00500-015-1809-z

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