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Investigation of different neural models for blood cell type identification

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Abstract

The analysis of blood cells in microscope images can provide useful information concerning the health of patients; however, manual classification of blood cells is time-consuming and susceptible to error due to the different morphological features of the cells. Therefore, a fast and automated method for identifying the different blood cells is required. In this paper, we investigate the use of different neural network models for the purpose of cell identification. The neural models are based on the back propagation learning algorithm and differ in design according to the way data features are extracted from the cell microscopic images. Three different topologies of neural networks are investigated, and a comparison between these models is drawn. Experimental results suggest that the proposed method performs well in identifying blood cell types regardless of their irregular shapes, sizes, and orientation.

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References

  1. Michalewicz Z, Schmidt M, Michalewicz M, Chiriac C (2005) Case study: an ıntelligent decision-support system. IEEE Intell Syst 20(4):44–49

    Article  Google Scholar 

  2. Sheikh H, Zhu B, Micheli–Tzanakou E (1997) Neural networks and blood cell identification. J Med Syst 21(4):201–210

    Article  Google Scholar 

  3. Lin W, Xiao J, Micheli-Tzanakou E (1998) A computational intelligence system for cell classification. IEEE ınternational conference on ınformation technology applications to biomedicine, May 1998, pp 105–109

  4. Shitong W, Min W (2006) A new detection algorithm (NDA) based on fuzzy cellular neural networks for white blood cell detection. IEEE Trans Inf Technol Biomed 10(1):5–10

    Article  Google Scholar 

  5. Buxton BF, Abdallahi H, Fernandez-Reyes D, Jarra W (2007) Development of an extension of the Otsu algorithm for multidimensional image segmentation of thin-film blood slides. IEEE ınternational conference on computing: theory and applications, March 2007, pp 552–562

  6. Scotti F (2006) Robust segmentation and measurements techniques of white cells in blood microscope images. IEEE ınstrumentation and measurement technology conference, April 2006, pp 43–48

  7. Wang W, Song H, Zhao Q (2006) A modified watersheds image segmentation algorithm for blood cell. IEEE ınternational conference on communications, circuits and systems, vol 1, June 2006, pp 450–454

  8. Yi F, Chongxun Z, Chen P, Li L (2005) White blood cell image segmentation using on-line trained neural network. IEEE conference on engineering in medicine and biology, Sept 2005, pp 6476–6479

  9. Theera-Umpon N, Dhompongsa S (2007) Morphological granulometric features of nucleus in automatic bone marrow white blood cell classification. IEEE Trans Inf Technol Biomed 11(3):353–359

    Article  Google Scholar 

  10. Mircic S, Jorgovanovic N (2006) Application of neural network for automatic classification of leukocytes. IEEE 8th seminar on neural network applications in electrical engineering, pp 141–144

  11. Markiewicz T, Osowski S, Marianska B, Moszczynski L (2005) Automatic recognition of the blood cells of myelogenous leukemia using SVM. Proceedings of ınternational joint conference on neural networks, Canada, Aug 2005, pp 2496–2501

  12. Zheng Q, Milthorpe BK, Jones AS (2004) Direct neural network application for automated cell recognition. Cytometry A 57(1):1–9

    Article  Google Scholar 

  13. Khashman A (2008) IBCIS: ıntelligent blood cell identification system. Prog Nat Sci 18(10):1309–1314

    Article  Google Scholar 

  14. Khashman A (2008) Blood cell identification using a simple neural network. Int J Neural Syst 18(5):453–458

    Article  Google Scholar 

  15. Khashman A (2009) Application of an emotional neural network to facial recognition. Neural Comput Appl 18(4):309–320

    Article  Google Scholar 

  16. Khashman A (2009) Blood cell identification using emotional neural networks. J Inf Sci Eng 25(6):1737–1751

    Google Scholar 

  17. Khashman A (2010) Blood cell type identification using different emotional neural network models. J Multiple Valued Logic Soft Comput 16(1–2):17–35

    Google Scholar 

  18. Khashman A (2010) An emotional system with application to blood cell type identification. Transactions of the ınstitute of measurement and control, SAGE publications, pp 1–23. doi:10.1177/0142331210366640

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Correspondence to Adnan Khashman.

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Khashman, A. Investigation of different neural models for blood cell type identification. Neural Comput & Applic 21, 1177–1183 (2012). https://doi.org/10.1007/s00521-010-0476-3

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  • DOI: https://doi.org/10.1007/s00521-010-0476-3

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