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Leukocyte image segmentation by visual attention and extreme learning machine

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Abstract

This paper presents a fast and simple framework for leukocyte image segmentation by learning with extreme learning machine (ELM) and sampling via simulating visual system. In sampling stage, visual attention and the effect of microsaccades in fixation are simulated. The high gradient pixels in fixation regions are sampled to group training set. We designed an automatic sampling process for leukocyte image according to the staining knowledge of blood smears. In learning stage, ELM classifier is trained online to simulate visual neuron system and then extracts pixels of object from image. The ELM-based segmentation is fully automatic by the proposed framework, which could find efficient samples actively, train the classification model in real time and almost no parameter adjusted. Experimental results demonstrated the new method could extract entire leukocyte from complex scenes, has equivalent performance compared to the SVM-based method and exceeds the marker-controlled watershed algorithm.

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Notes

  1. The doctor came from the pathology laboratory of Fourth Military Medical University, Xi’an, China.

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Acknowledgments

This research was financially supported by the Ministry of Education, Science Technology (MEST) and National Research Foundation of Korea (NRF) through the Human Resource Training Project for Regional Innovation, the grant Second stage of Brain Korea 21.

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Authors and Affiliations

  1. College of Information Engineering, China Jiliang University, 310018, Hangzhou, Zhejiang, China

    Chen Pan

  2. Division of Electronics and Information Engineering, Chonbuk National University, Jeonju, Jeonbuk, 561-756, Korea

    Chen Pan, Dong Sun Park & Hyouck Min Yoo

  3. School of Information Technology, Jiangxi University of Finance and Economics, 330013, Nanchang, Jiangxi, China

    Yong Yang

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  1. Chen Pan
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  2. Dong Sun Park
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  3. Yong Yang
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  4. Hyouck Min Yoo
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Correspondence to Chen Pan or Dong Sun Park.

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Pan, C., Park, D.S., Yang, Y. et al. Leukocyte image segmentation by visual attention and extreme learning machine. Neural Comput & Applic 21, 1217–1227 (2012). https://doi.org/10.1007/s00521-011-0522-9

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  • DOI: https://doi.org/10.1007/s00521-011-0522-9

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