Abstract
The recent advancements in information technology and bioinformatics have led to exceptional contributions in medical sciences. Extensive developments have been recorded for digital devices, thermometers, digital equipments and health monitoring systems for the automated disease diagnosis of different diseases. These automated systems assist doctors with accurate and efficient disease diagnosis. Parkinson’s disease is a neurodegenerative disorder that affects the nervous system. Over the years, numerous efforts have been reported for the efficient automatic detection of Parkinson’s disease. Different datasets including voice data samples, radiology images, and handwriting samples and gait specimens have been used for analysis and detection. Techniques such as machine learning and deep learning have been used broadly and reported promising results. This review paper aims to provide a comprehensive survey of the use of artificial intelligence for Parkinson’s disease diagnosis. The available datasets and their various properties are discussed in detail. Further, a thorough overview is provided for the existing algorithms, methods and approaches utilizing different datasets. Several key peculiarities and challenges are also provided based on the comprehensive literature review to diagnose a healthy or unhealthy person.








Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.References
Agarwal A, Chandrayan S, Sahu SS (2016) Prediction of Parkinson’s disease using speech signal with extreme learning machine. In: 2016 international conference on electrical, electronics, and optimization techniques (ICEEOT). IEEE, pp 3776–3779
Ahlrichs C, Lawo M (2013) Parkinson’s disease motor symptoms in machine learning: a review. arXiv preprint arXiv:1312.3825
Aich S, Kim HC, Hui KL, Al-Absi AA, Sain M et al (2019) A supervised machine learning approach using different feature selection techniques on voice datasets for prediction of Parkinson’s disease. In: 2019 21st international conference on advanced communication technology (ICACT). IEEE, pp. 1116–1121
Akyol K (2017) A study on the diagnosis of Parkinson’s disease using digitized wacom graphics tablet dataset. Int J Inf Technol Comput Sci 9:45–51
Al-Fatlawi AH, Jabardi MH, Ling SH (2016) Efficient diagnosis system for Parkinson’s disease using deep belief network. In: 2016 IEEE congress on evolutionary computation (CEC). IEEE, pp 1324–1330
Alhussein M (2017) Monitoring Parkinson’s disease in smart cities. IEEE Access 5:19835–19841
Ali L, Zhu C, Zhou M, Liu Y (2019) Early diagnosis of Parkinson’s disease from multiple voice recordings by simultaneous sample and feature selection. Expert Syst Appl 137:22–28
Almeida JS, Reboucas PP, Carneiro T, Wei W, Damasevicius R, Maskeliunas R, de Albuquerque VHC (2019) Detecting Parkinson’s disease with sustained phonation and speech signals using machine learning techniques. Pattern Recognit Lett 125:55–62
Alomari MA, Khalil H, Khabour OF, Wood R (2018) Cardiovascular function is related to neuromuscular performance in Parkinson’s disease. Neurodegener Dis Manag 8(4):243–255
Alqahtani EJ, Alshamrani FH, Syed HF, Olatunji SO (2018) Classification of Parkinson’s disease using nnge classification algorithm. In: 2018 21st Saudi computer society national computer conference (NCC). IEEE, pp 1–7
Amoroso N, La Rocca M, Monaco A, Bellotti R, Tangaro S (2018) Complex networks reveal early MRI markers of Parkinson’s disease. Med Image Anal 48:12–24
Armananzas R, Bielza C, Chaudhuri KR, Martinez-Martin P, Larranaga P (2013) Unveiling relevant non-motor Parkinson’s disease severity symptoms using a machine learning approach. Artif Intell Med 58(3):195–202
Arora S, Baghai-Ravary L, Tsanas A (2019) Developing a large scale population screening tool for the assessment of Parkinson’s disease using telephone-quality voice. J Acoust Soc Am 145(5):2871–2884
Baby MS, Saji A, Kumar CS (2017) Parkinsons disease classification using wavelet transform based feature extraction of gait data. In: 2017 international conference on circuit, power and computing technologies (ICCPCT). IEEE, pp 1–6
Bachlin M, Plotnik M, Roggen D, Maidan I, Hausdorff JM, Giladi N, Troster G (2009) Wearable assistant for Parkinson’s disease patients with the freezing of gait symptom. IEEE Trans Inf Technol Biomed 14(2):436–446
Badea L, Onu M, Wu T, Roceanu A, Bajenaru O (2017) Exploring the reproducibility of functional connectivity alterations in Parkinson’s disease. PLoS ONE 12(11):127
Banerjee M, Okun MS, Vaillancourt DE, Vemuri BC (2016) A method for automated classification of Parkinson’s disease diagnosis using an ensemble average propagator template brain map estimated from diffusion mri. PLoS ONE 11(6):e0155764
Bansode P, Chivte V, Nikalje A (2018) EC pharmacology and toxicology: a brief review on Parkinson’s disease
Bayestehtashk A, Asgari M, Shafran I, McNames J (2015) Fully automated assessment of the severity of Parkinson’s disease from speech. Comput Speech Lang 29(1):172–185
Behroozi M, Sami A (2016) A multiple-classifier framework for Parkinson’s disease detection based on various vocal tests. Int J Telemed Appl 2016:256
Benba A, Jilbab A, Hammouch A (2014) Voice analysis for detecting persons with Parkinson’s disease using MFCC and VQ. In: The 2014 international conference on circuits, systems and signal processing, pp 23–25
Benba, A., Jilbab, A., Hammouch, A.: Voiceprint analysis using perceptual linear prediction and support vector machines for detecting persons with parkinson’s disease. In: The 3rd international conference on health science and biomedical systems, pp. 22–24 (2014)
Benba A, Jilbab A, Hammouch A (2016) Analysis of multiple types of voice recordings in cepstral domain using MFCC for discriminating between patients with Parkinson’s disease and healthy people. Int J Speech Technol 19(3):449–456
Benba A, Jilbab A, Hammouch A (2017) Using human factor cepstral coefficient on multiple types of voice recordings for detecting patients with Parkinson’s disease. IRBM 38(6):346–351
Benba A, Jilbab A, Hammouch A, Sandabad S (2015) Voiceprints analysis using mfcc and svm for detecting patients with Parkinson’s disease. In: 2015 international conference on electrical and information technologies (ICEIT). IEEE, pp 300–304
Benmalek E, Elmhamdi J, Jilbab A (2018) Multiclass classification of Parkinson’s disease using cepstral analysis. Int J Speech Technol 21(1):39–49
Bernardo LS, Quezada A, Munoz R, Maia FM, Pereira CR, Wu W, de Albuquerque VHC (2019) Handwritten pattern recognition for early Parkinson’s disease diagnosis. Pattern Recognit Lett 125:78–84
Bielby J, Kuhn S, Colreavy-Donnelly S, Caraffini F, O’Connor S, Anastassi Z (2020) Identifying Parkinson’s disease through the classification of audio recording data. IEEE
Big C, Reineck LA, Aronoff DM (2009) Viral infections of the central nervous system: a case-based review. Clin Med Res 7(4):142–146
B¨ohme M, Paul S (2014) On the efficiency of automated testing. In: Proceedings of the 22nd ACM SIGSOFT international symposium on foundations of software engineering, pp 632–642
Bougea A, Anagnostou E, Konstantinos G, George P, Triantafyllou N, Kararizou E (2015) A systematic review of peripheral and central nervous system involvement of rheumatoid arthritis, systemic lupus erythematosus, primary Sjogren’s syndrome, and associated immunological profiles. Int J Chron Dis 2015:897
Braga D, Madureira AM, Coelho L, Ajith R (2019) Automatic detection of Parkinson’s disease based on acoustic analysis of speech. Eng Appl Artif Intell 77:148–158
Broeder S, Nackaerts E, Nieuwboer A, Smits-Engelsman BC, Swinnen SP, Heremans E (2014) The effects of dual tasking on handwriting in patients with Parkinson’s disease. Neuroscience 263:193–202
Caesarendra W, Putri FT, Ariyanto M, Setiawan JD (2015) Pattern recognition methods for multi stage classification of Parkinson’s disease utilizing voice features. In: 2015 IEEE international conference on advanced intelligent mechatronics (AIM). IEEE, pp 802–807
Camps J, Sama A, Martin M, Rodrıguez-Martın D, Perez-Lopez C, Alcaine S, Mestre B, Prats A, Crespo MC, Cabestany J et al (2017) Deep learning for detecting freezing of gait episodes in Parkinson’s disease based on accelerometers. In: International work-conference on artificial neural networks. Springer, pp 344–355
Can M (2013) Neural networks to diagnose the Parkinson’s disease. Southeast Europe J Soft Comput 2(1):7
Channa A, Popescu N, Ciobanu V (2020) Wearable solutions for patients with Parkinson’s disease and neurocognitive disorder: a systematic review. Sensors 20(9):2713
Chen HL, Wang G, Ma C, Cai ZN, Liu WB, Wang SJ (2016) An efficient hybrid kernel extreme learning machine approach for early diagnosis of Parkinson s disease. Neurocomputing 184:131–144
Chen L, Hagenah J, Mertins A (2012) Feature analysis for Parkinson’s disease detection based on transcranial sonography image. In: international conference on medical image computing and computer-assisted intervention. Springer, pp 272–279
Chen X, Yao X, Tang C, Sun Y, Wang X, Wu X (2018) Detecting Parkinson’s disease using gait analysis with particle swarm optimization. In: international conference on human aspects of IT for the aged population. Springer, pp 263–275
Cho CW, Chao WH, Lin SH, Chen YY (2009) A vision-based analysis system for gait recognition in patients with Parkinson’s disease. Expert Syst Appl 36(3):7033–7039
Chrischilles EA, Rubenstein LM, Voelker MD, Wallace RB, Rodnitzky RL (1998) The health burdens of Parkinson’s disease. Mov Disord 13(3):406–413
Cigdem O, Beheshti I, Demirel H (2018) Effects of different covariates and contrasts on classification of Parkinson’s disease using structural MRI. Comput Biol Med 99:173–181
Dauer W, Przedborski S (2003) Parkinson’s disease: mechanisms and models. Neuron 39(6):889–909
Diaz M, Ferrer MA, Impedovo D, Pirlo G, Vessio G (2019) Dynamically enhanced static handwriting representation for Parkinson’s disease detection. Pattern Recognit Lett 128:204–210
Dorsey ER, Elbaz A, Nichols E, Abd-Allah F, Abdelalim A, Adsuar JC, Ansha MG, Brayne C, Choi JYJ, Collado-Mateo D et al (2018) Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet Neurol 17(11):939–953
Drotar P, Mekyska J, Rektorova I, Masarova L, Smekal Z, Faundez-Zanuy M (2014) Analysis of in-air movement in handwriting: a novel marker for parkinson’s disease. Comput Methods Programs Biomed 117(3):405–411
Drotar P, Mekyska J, Rektorova I, Masarova L, Smekal Z, Faundez-Zanuy M (2014) Decision support frame-work for Parkinson’s disease based on novel handwriting markers. IEEE Trans Neural Syst Rehab Eng 23(3):508–516
Drotar P, Mekyska J, Rektorova I, Masarova L, Smekal Z, Faundez-Zanuy M (2016) Evaluation of handwriting kinematics and pressure for differential diagnosis of Parkinson’s disease. Artif Intell Med 67:39–46
Drotar P, Mekyska J, Smekal Z, Rektorova I, Masarova L, Faundez-Zanuy M (2015) Contribution of different handwriting modalities to differential diagnosis of Parkinson’s disease. In: 2015 IEEE international symposium on medical measurements and applications (MeMeA) proceedings. IEEE, pp 344–348
Dunne-Willows M, Watson P, Shi J, Rochester L, Del Din S (2019) A novel parameterisation of phase plots for monitoring of parkinson’s disease. In: 2019 41st annual international conference of the IEEE engineering in medicine and biology society (EMBC). IEEE, pp 5890–5893
El Maachi I, Bilodeau GA, Bouachir W (2020) Deep 1d-convnet for accurate parkinson disease detection and severity prediction from gait. Expert Syst Appl 143:113075
Eskofier BM, Lee SI, Daneault JF, Golabchi FN, Ferreira-Carvalho G, Vergara-Diaz G, Sapienza S, Costante G, Klucken J, Kautz T et al (2016) Recent machine learning advancements in sensor-based mobility analysis: deep learning for Parkinson’s disease assessment. In: 2016 38th annual international conference of the IEEE engineering in medicine and biology society (EMBC). IEEE, pp 655–658
Ferrucci R, Cortese F, Bianchi M, Pittera D, Turrone R, Bocci T, Borroni B, Vergari M, Cogiamanian F, Ardolino G et al (2016) Cerebellar and motor cortical transcranial stimulation decrease levodopa-induced dyskinesias in parkinson’s disease. The Cerebellum 15(1):43–47
Gallicchio C, Micheli A, Pedrelli L (2016) Deep echo state networks for diagnosis of Parkinson’s disease. arXiv preprint arXiv:1802.06708
Garcıa AM, Carrillo F, Orozco-Arroyave JR, Trujillo N, Bonilla JFV, Fittipaldi S, Adolfi F, Noth E, Sigman M, Slezak DF et al (2016) How language flows when movements don’t: an automated analysis of spontaneous discourse in parkinson’s disease. Brain Lang 162:19–28
Gavrilescu M (2015) Study on determining the myers-briggs personality type based on individual’s handwriting. In: 2015 E-health and bioengineering conference (EHB). IEEE, pp 1–6
Gil D, Manuel DJ (2009) Diagnosing parkinson by using artificial neural networks and support vector machines. Glob J Comput Sci Technol 9(4):256
Gil-Martın M, Montero JM, San-Segundo R (2019) Parkinson’s disease detection from drawing movements using convolutional neural networks. Electronics 8(8):907
Giladi N, Nieuwboer A (2008) Understanding and treating freezing of gait in parkinsonism, proposed working definition, and setting the stage. Mov Disord 23(S2):S423–S425
Goldberger AL, Amaral LA, Glass L, Hausdorff JM, Ivanov PC, Mark RG, Mietus JE, Moody GB, Peng CK, Stanley HE (2000) Physiobank, physiotoolkit, and physionet: components of a new research resource for complex physiologic signals. Circulation 101(23):e215–e220
Gupta D, Julka A, Jain S, Aggarwal T, Khanna A, Arunkumar N, de Albuquerque VHC (2018) Optimized cuttlefish algorithm for diagnosis of parkinson’s disease. Cogn Syst Res 52:36–48
Gupta D, Sundaram S, Khanna A, Hassanien AE, De Albuquerque VHC (2018) Improved diagnosis of Parkinson’s disease using optimized crow search algorithm. Comput Electr Eng 68:412–424
Gupta JD, Chanda B (2019) Novel features for diagnosis of parkinson’s disease from off-line archimedean spiral images. In: 2019 IEEE 10th international conference on awareness science and technology (iCAST). IEEE, pp 1–6
Gupta U, Bansal H, Joshi D (2020) An improved sex-specific and age-dependent classification model for Parkinson’s diagnosis using handwriting measurement. Comput Methods Programs Biomed 189:105305
Guttman M, Slaughter P, Theriault ME, DeBoer D, Naylor C (2001) Parkinsonism in ontario: increased mortality compared with controls in a large cohort study. Neurology 57(12):2278–2282
Hamdi S, Laouini O. Computer aided diagnosis system for Parkinson’s disease detection based on histogramm equalization and support vector machine
Haq AU, Li JP, Memon MH, Malik A, Ahmad T, Ali A, Nazir S, Ahad I, Shahid M et al (2019) Feature selection based on l1-norm support vector machine and effective recognition system for Parkinson’s disease using voice recordings. IEEE Access 7:37718–37734
Huang YP, Singh P, Kuo HC (2020) A hybrid fuzzy clustering approach for the recognition and visualization of MRI images of Parkinson’s disease. IEEE Access 8:25041–25051
Impedovo D (2019) Velocity-based signal features for the assessment of parkinsonian handwriting. IEEE Signal Process Lett 26(4):632–636
Impedovo D, Pirlo G, Vessio G (2018) Dynamic handwriting analysis for supporting earlier Parkinson’s disease diagnosis. Information 9(10):247
Isenkul M, Sakar B, Kursun O (2014) Improved spiral test using digitized graphics tablet for monitoring Parkinson’s disease. In: Proceedings of the international conference on e-health and telemedicine, pp 171–175 (2014)
Islam MS, Parvez I, Deng H, Goswami P (2014) Performance comparison of heterogeneous classifiers for detection of Parkinson’s disease using voice disorder (dysphonia). In: 2014 international conference on informatics, electronics & vision (ICIEV). IEEE, pp 1–7
Jafari A (2013) Classification of Parkinson’s disease patients using nonlinear phonetic features and mel-frequency cepstral analysis. Biomed Eng Appl Basis Commun 25(04):1350001
Jain S, Shetty S (2016) Improving accuracy in noninvasive telemonitoring of progression of Parkinson’s disease using two-step predictive model. In: 2016 third international conference on electrical, electronics, computer engineering and their applications (EECEA). IEEE, pp 104–109
Jankovic J (2008) Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psych 79(4):368–376
Jin L, Zeng Q, He J, Feng Y, Zhou S, Wu Y (2019) A Relieff-SVM-based method for marking dopamine-based disease characteristics: a study on Swedd and Parkinson’s disease. Behav Brain Res 356:400–407
Kamran I, Naz S, Razzak I, Imran M (2021) Handwriting dynamics assessment using deep neural network for early identification of Parkinson’s disease. Futur Gener Comput Syst 117:234–244
Karimi Rouzbahani H, Daliri MR (2011) Diagnosis of Parkinson’s disease in human using voice signals. Basic Clin Neurosci 2(3):12–20
Khan AA (2013) Detecting freezing of gait in parkinson’s disease for automatic application of rhythmic auditory stimuli. Ph.D. thesis, University of Reading
Khan T, Westin J, Dougherty M (2014) Cepstral separation difference: A novel approach for speech impairment quantification in Parkinson’s disease. Biocybern Biomed Eng 34(1):25–34
Kollia I, Stafylopatis AG, Kollias S (2019) Predicting Parkinson’s disease using latent information extracted from deep neural networks. In: 2019 international joint conference on neural networks (IJCNN). IEEE, pp 1–8
Kollias D, Tagaris A, Stafylopatis A, Kollias S, Tagaris G (2018) Deep neural architectures for prediction in healthcare. Complex Intell Syst 4(2):119–131
Kondragunta J, Wiede C, Hirtz G (2019) Gait analysis for early Parkinson’s disease detection based on deep learning. Curr Dir Biomed Eng 5(1):9–12
Lahmiri S, Shmuel A (2019) Detection of Parkinson’s disease based on voice patterns ranking and optimized support vector machine. Biomed Signal Process Control 49:427–433
Laukamp KR, Thiele F, Shakirin G, Zopfs D, Faymonville A, Timmer M, Maintz D, Perkuhn M, Borggrefe J (2019) Fully automated detection and segmentation of meningiomas using deep learning on routine multiparametric mri. Eur Radiol 29(1):124–132
Levin SN, Lyons JL (2018) Infections of the nervous system. Am J Med 131(1):25–32
Little M, McSharry P, Hunter E, Spielman J, Ramig L (2008) Suitability of dysphonia measurements for telemonitoring of Parkinson’s disease. Nat Preced 25:1
Little MA, McSharry PE, Roberts SJ, Costello DA, Moroz IM (2007) Exploiting nonlinear recurrence and fractal scaling properties for voice disorder detection. Biomed Eng Online 6(1):23
Little S, Beudel M, Zrinzo L, Foltynie T, Limousin P, Hariz M, Neal S, Cheeran B, Cagnan H, Gratwicke J et al (2016) Bilateral adaptive deep brain stimulation is effective in Parkinson’s disease. J Neurol Neurosurg Psychiatry 87(7):717–721
Liu H, Wang EQ, Metman LV, Larson CR (2012) Vocal responses to perturbations in voice auditory feedback in individuals with Parkinson’s disease. PLoS ONE 7(3):25897
Loconsole C, Cascarano GD, Brunetti A, Trotta GF, Losavio G, Bevilacqua V, Di Sciascio E (2019) A model-free technique based on computer vision and SEMG for classification in Parkinson’s disease by using computer-assisted handwriting analysis. Pattern Recognit Lett 121:28–36
Long D, Wang J, Xuan M, Gu Q, Xu X, Kong D, Zhang M (2012) Automatic classification of early Parkinson’s disease with multi-modal mr imaging. PLoS ONE 7(11):56721
Ma C, Ouyang J, Chen HL, Zhao XH (2014) An efficient diagnosis system for Parkinson’s disease using kernel-based extreme learning machine with subtractive clustering features weighting approach. Comput Math Methods Med 2014:546
Marek K, Jennings D, Lasch S, Siderowf A, Tanner C, Simuni T, Coffey C, Kieburtz K, Flagg E, Chowdhury S et al (2011) The Parkinson progression marker initiative (PPMI). Prog Neurobiol 95(4):629–635
Mathur R, Pathak V, Bandil D (2019) Parkinson disease prediction using machine learning algorithm. In: Emerging trends in expert applications and security. Springer, pp 357–363
McGill A, Houston S, Lee RY (2019) Effects of a ballet-based dance intervention on gait variability and balance confidence of people with parkinson’s. Arts Health 11(2):133–146
Medeiros L, Almeida H, Dias L, Perkusich M, Fischer R (2016) A gait analysis approach to track Parkinson’s disease evolution using principal component analysis. In: 2016 IEEE 29th international symposium on computer-based medical systems (CBMS). IEEE, pp 48–53
Medicine GNR (2015) 6 dimensions of Parkinson’s disease. URL https://interestingmedical.com/-dimensions-of-parkinsons-disease/. Accessed 1 Mar 2020
Meghraoui D, Boudraa B, Merazi-Meksen T, Boudraa M (2016) Parkinson’s disease recognition by speech acoustic parameters classification. In: modelling and implementation of complex systems. Springer, pp 165–173
Mekyska J, Smekal Z, Drotar P, Masarova L, Rektorova I, Faundez-Zanuy M. Parkinson’s disease hand-writing database (PAHAW)
Mendonca IP, Duarte-Silva E, Chaves-Filho AJM, Peixoto CA et al (2020) Neurobiological findings under- lying depressive behavior in park. Int Immunopharmacol 83:106434
Moetesum M, Siddiqi I, Vincent N, Cloppet F (2019) Assessing visual attributes of handwriting for prediction of neurological disorders—a case study on parkinson’s disease. Pattern Recognit Lett 121:19–27
Monajemi S, Eftaxias K, Sanei S, Ong SH (2016) An informed multitask diffusion adaptation approach to study tremor in Parkinson’s disease. IEEE J Sel Top Signal Process 10(7):1306–1314
Montana D, Campos-Roca Y, Perez CJ (2018) A diadochokinesis-based expert system considering articulatory features of plosive consonants for early detection of Parkinson’s disease. Comput Methods Programs Biomed 154:89–97
Moon S, Song HJ, Sharma VD, Lyons KE, Pahwa R, Akinwuntan AE, Devos H (2020) Classification of Parkinson’s disease and essential tremor based on balance and gait characteristics from wearable motion sensors via machine learning techniques: a data-driven approach. J Neuroeng Rehabil 17(1):1–8
Morales DA, Vives-Gilabert Y, Gomez-Anson B, Bengoetxea E, Larranaga P, Bielza C, Pagonabarraga J, Kulisevsky J, Corcuera-Solano I, Delfino M (2013) Predicting dementia development in parkinson’s disease using bayesian network classifiers. Psych Res NeuroImaging 213(2):92–98
Morton G, Cummings D, Baskin D, Barsh G, Schwartz M (2006) Central nervous system control of food intake and body weight. Nature 443(7109):289–295
Mostafa SA, Mustapha A, Mohammed MA, Hamed RI, Arunkumar N, Ghani MKA, Jaber MM, Khaleefah SH (2019) Examining multiple feature evaluation and classification methods for improving the diagnosis of Parkinson’s disease. Cogn Syst Res 54:90–99
Munoz DA, Kilinc MS, Nembhard HB, Tucker C, Huang X (2017) Evaluating the cost-effectiveness of an early detection of Parkinson’s disease through innovative technology. Eng Econ 62(2):180–196, 235
Nackaerts E, Broeder S, Pereira MP, Swinnen SP, Vandenberghe W, Nieuwboer A, Heremans E (2017) Hand-writing training in Parkinson’s disease: a trade-off between size, speed and fluency. PLoS ONE 12(12):89
Nackaerts E, Heremans E, Smits-Engelsman BC, Broeder S, Vandenberghe W, Bergmans B, Nieuwboer A (2017) Validity and reliability of a new tool to evaluate handwriting difficulties in parkinson’s disease. PLoS ONE 12(3):78456
Naranjo L, Perez CJ, Campos-Roca Y, Martın J (2016) Addressing voice recording replications for Parkinson’s disease detection. Expert Syst Appl 46:286–292
Naranjo L, Perez CJ, Martın J, Campos-Roca Y (2017) A two-stage variable selection and classification approach for Parkinson’s disease detection by using voice recording replications. Comput Methods Programs Biomed 142:147–156
Naseer A, Rani M, Naz S, Razzak MI, Imran M, Xu G (2020) Refining Parkinson’s neurological disorder identification through deep transfer learning. Neural Comput Appl 32(3):839–854
Oh SL, Hagiwara Y, Raghavendra U, Yuvaraj R, Arunkumar N, Murugappan M, Acharya UR (2018) A deep learning approach for Parkinson’s disease diagnosis from eeg signals. Neural Comput Appl 1–7
Oikonomou VP, Blekas K, Astrakas L (2018) Functional connectivity in Parkinson disease through mixture modelling. In: 2018 IEEE 13th image, video, and multidimensional signal processing workshop (IVMSP). IEEE, pp 1–5
Orozco-Arroyave JR, Arias-Londono JD, Vargas-Bonilla JF, Gonzalez-R´ativa MC, Noth E (2014) New spanish speech corpus database for the analysis of people suffering from Parkinson’s disease. In: LREC, pp 342–347
Orozco-Arroyave JR, Belalcazar-Bolanos EA, Arias-Londono JD, Vargas-Bonilla JF, Skodda S, Rusz J, Daqrouq K, Honig F, Noth E (2015) Characterization methods for the detection of multiple voice disorders: neurological, functional, and laryngeal diseases. IEEE J Biomed Health Inf 19(6):1820–1828
Orozco-Arroyave JR, Garcıa N, Vargas-Bonilla JF, Noth E (2015) Automatic detection of Parkinson’s disease from compressed speech recordings. In: International conference on text, speech, and dialogue. Springer, pp 88–95
Orozco-Arroyave JR, Honig F, Arias-Londono JD, Vargas-Bonilla JF, Skodda S, Rusz J, Noth E (2014) Automatic detection of parkinson’s disease from words uttered in three different languages. In: Fifteenth annual conference of the international speech communication association
Orozco-Arroyave JR, Honig F, Arias-Londono JD, Vargas-Bonilla JF, Skodda S, Rusz J, Noth E (2015) Voiced/unvoiced transitions in speech as a potential bio-marker to detect Parkinson’s disease. In: Sixteenth annual conference of the international speech communication association
Orphanidou NK, Hussain A, Keight R, Lishoa P, Hind J, Al-Askar H (2018) Predicting freezing of gait in Parkinsons disease patients using machine learning. In: 2018 IEEE congress on evolutionary computation (CEC). IEEE, pp 1–8
O’Sullivan JD, Said CM, Dillon LC, Hoffman M, Hughes AJ (1998) Gait analysis in patients with Parkinson’s disease and motor fluctuations: influence of levodopa and comparison with other measures of motor function. Mov Disord 13(6):900–906
Oung QW, Muthusamy H, Basah SN, Lee H, Vijean V (2018) Empirical wavelet transform based features for classification of Parkinson’s disease severity. J Med Syst 42(2):29
Pahuja G, Nagabhushan T, Prasad B, Pushkarna R (2018) Early detection of Parkinson’s disease through multi-modal features using machine learning approaches. Int J Signal Imaging Syst Eng 11(1):31–43
Pang SYY, Ho PWL, Liu HF, Leung CT, Li L, Chang EES, Ramsden DB, Ho SL (2019) The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease. Transl Neurode-gener 8(1):1–11
Parisi L, RaviChandran N, Manaog ML (2018) Feature-driven machine learning to improve early diagnosis of Parkinson’s disease. Expert Syst Appl 110:182–190
Pasman EP, McKeown MJ, Cleworth TW, Bloem BR, Inglis JT, Carpenter MG (2019) A novel MRI compatible balance simulator to detect postural instability in Parkinson’s disease. Front Neurol 10:922
Pearce JM (1989) Aspects of the history of Parkinson’s disease. J Neurol Neurosurg Psych 52(Suppl):6
Penberthy L, Brown R, Puma F, Dahman B (2010) Automated matching software for clinical trials eligibility: measuring efficiency and flexibility. Contemp Clin Trials 31(3):207–217
Peng B, Wang S, Zhou Z, Liu Y, Tong B, Zhang T, Dai Y (2017) A multilevel-ROI-features-based machine learning method for detection of morphometric biomarkers in Parkinson’s disease. Neurosci Lett 651:88–94
Pepa L, Capecci M, Andrenelli E, Ciabattoni L, Spalazzi L, Ceravolo MG (2020) A fuzzy logic system for the home assessment of freezing of gait in subjects with Parkinsons disease. Expert Syst Appl 186:113197
Pereira CR, Pereira DR, Rosa GH, Albuquerque VH, Weber SA, Hook C, Papa JP (2018) Handwritten dynamics assessment through convolutional neural networks: an application to Parkinson’s disease identification. Artif Intell Med 87:67–77
Pereira CR, Pereira DR, Silva FA, Masieiro JP, Weber SA, Hook C, Papa JP (2016) A new computer vision-based approach to aid the diagnosis of Parkinson’s disease. Comput Methods Programs Biomed 136:79–88
Pereira CR, Pereira DR, Weber SA, Hook C, de Albuquerque VHC, Papa JP (2019) A survey on computer-assisted Parkinson’s disease diagnosis. Artif Intell Med 95:48–63
Pereira CR, Weber SA, Hook C, Rosa GH, Papa JP (2016) Deep learning-aided Parkinson’s disease diagnosis from handwritten dynamics. In: 2016 29th SIBGRAPI conference on graphics, patterns and images (SIBGRAPI). IEEE, pp 340–346
Pereira CR, Weber SAT, Hook C, Rosa GH, Papa JP (2016) Deep Learning-aided Parkinson’s disease diagnosis from handwritten dynamics. In: Proceedings of the SIBGRAPI 2016—conference on graphics, patterns and images
Pham TT, Moore ST, Lewis SJG, Nguyen DN, Dutkiewicz E, Fuglevand AJ, McEwan AL, Leong PH (2017) Freezing of gait detection in Parkinson’s disease: a subject-independent detector using anomaly scores. IEEE Trans Biomed Eng 64(11):2719–2728
Plamondon R, Srihari SN (2000) Online and off-line handwriting recognition: a comprehensive survey. IEEE Trans Pattern Anal Mach Intell 22(1):63–84
Plummer P (2019) Critically appraised paper: exercise interventions improve some walking-related outcomes in people with Parkinson’s disease [synopsis]. J Physiother 65(2):108
Polat K (2019) A hybrid approach to Parkinson disease classification using speech signal: the combination of smote and random forests. In: 2019 scientific meeting on electrical-electronics & biomedical engineering and computer science (EBBT). IEEE, pp 1–3
Poorjam AH, Raykov YP, Badawy R, Jensen JR, Christensen MG, Little MA (2019) Quality control of voice recordings in remote parkinson’s disease monitoring using the infinite hidden markov model. In: ICASSP 2019-2019 IEEE international conference on acoustics, speech and signal processing (ICASSP). IEEE, pp 805–809
Poser CM (1987) The peripheral nervous system in multiple sclerosis: a review and pathogenetic hypothesis. J Neurol Sci 79(1–2):83–90
Prashanth R, Roy SD, Mandal PK, Ghosh S (2014) Parkinson’s disease detection using olfactory loss and rem sleep disorder features. In: 2014 36th annual international conference of the IEEE engineering in medicine and biology society. IEEE, pp 5764–5767
Pringsheim T, Jette N, Frolkis A, Steeves TD (2014) The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord 29(13):1583–1590
Proenca J, Veiga A, Candeias S, Lemos J, Januario C, Perdigao F (2014) Characterizing Parkinson’s disease speech by acoustic and phonetic features. In: International conference on computational processing of the portuguese language. Springer, pp 24–35
Przybyszewski AW (2014) Applying data mining and machine learning algorithms to predict symptom development in Parkinson’s disease. In: Annales academiae medicae silesiensis, vol 68, pp 332–349
Rajanikanth C, Amardeep A, Kishore B, Azeez S. Detection of Parkinson’s disease by speech analysis
Razzak I, Kamran I, Naz S (2020) Deep analysis of handwritten notes for early diagnosis of neurological disorders. In: 2020 international joint conference on neural networks (IJCNN). IEEE, pp 1–6
Rehman A, Naz S, Razzak I (2021) Leveraging big data analytics in healthcare enhancement: trends, challenges and opportunities. Multimed Syst 56:1–33
Rewar S (2015) A systematic review on Parkinson’s disease (PD). Indian J Res Pharm Biotechnol 3(2):176
Rios-Urrego CD, Vasquez-Correa JC, Vargas-Bonilla JF, Noth E, Lopera F, Orozco-Arroyave JR (2019) Analysis and evaluation of handwriting in patients with Parkinson’s disease using kinematic, geometrical, and non-linear features. Comput Methods Programs Biomed 173:43–52
Rosenblum S, Dvorkin AY, Weiss PL (2006) Automatic segmentation as a tool for examining the handwriting process of children with dysgraphic and proficient handwriting. Hum Mov Sci 25(4–5):608–621
Rosenblum S, Samuel M, Zlotnik S, Erikh I, Schlesinger I (2013) Handwriting as an objective tool for Parkinson’s disease diagnosis. J Neurol 260(9):2357–2361
Ross GW, Abbott RD, Petrovitch H, Morens DM, Grandinetti A, Tung KH, Tanner CM, Masaki KH, Blanchette PL, Curb JD et al (2000) Association of coffee and caffeine intake with the risk of parkinson disease. JAMA 283(20):2674–2679
Rusz J, Cmejla R, Ruzickova H, Ruzicka E (2011) Objectification of dysarthria in Parkinson’s disease using bayes theorem. Age (Year) 61(1260):58–68
Rusz J, Cmejla R, Ruzickova H, Ruzicka E (2011) Quantitative acoustic measurements for characterization of speech and voice disorders in early untreated Parkinson’s disease. J Acoust Soc Am 129(1):350–367
Sakar BE, Isenkul ME, Sakar CO, Sertbas A, Gurgen F, Delil S, Apaydin H, Kursun O (2013) Collection and analysis of a parkinson speech dataset with multiple types of sound recordings. IEEE J Biomed Health Inform 17(4):828–834
Salvatore C, Cerasa A, Castiglioni I, Gallivanone F, Augimeri A, Lopez M, Arabia G, Morelli M, Gilardi M, Quattrone A (2014) Machine learning on brain mri data for differential diagnosis of Parkinson’s disease and progressive supranuclear palsy. J Neurosci Methods 222:230–237
Scheife RT, Schumock GT, Burstein A, Gottwald MD, Luer MS (2000) Impact of Parkinson’s disease and its pharmacologic treatment on quality of life and economic outcomes. Am J Health Syst Pharm 57(10):953–962
Scott LJ (2016) Opicapone: a review in Parkinson’s disease. Drugs 76(13):1293–1300
Senturk ZK (2020) Early diagnosis of Parkinson’s disease using machine learning algorithms. Med Hyp 138:109603
Shahbakhi M, Far DT, Tahami E (2014) Speech analysis for diagnosis of Parkinson’s disease using genetic algorithm and support vector machine. J Biomed Sci Eng 2014:8547
Shanahan J, Morris ME, Bhriain ON, Volpe D, Lynch T, Clifford AM (2017) Dancing for parkinson disease: a randomized trial of irish set dancing compared with usual care. Arch Phys Med Rehabil 98(9):1744–1751
Sharma A, Giri RN (2013) An elegant approach for diagnosis of parkinson’s disease on mri brain images by means of a neural network. Int J Eng Sci Res Technol 2(9):2553–2557
Sharma P, Sundaram S, Sharma M, Sharma A, Gupta D (2019) Diagnosis of Parkinson’s disease using modified grey wolf optimization. Cogn Syst Res 54:100–115
Shinde S, Prasad S, Saboo Y, Kaushick R, Saini J, Pal PK, Ingalhalikar M (2019) Predictive markers for Parkinson’s disease using deep neural nets on neuromelanin sensitive mri. Neuroimage Clin 22:101748
Shirvan RA, Tahami E (2011) Voice analysis for detecting Parkinson’s disease using genetic algorithm and knn classification method. In: 2011 18th Iranian conference of biomedical engineering (ICBME). IEEE, pp 278–283
Shukla AK, Singh P, Vardhan M (2019) Medical diagnosis of Parkinson disease driven by multiple preprocessing technique with scarce lee silverman voice treatment data. In: Engineering vibration, communication and information processing. Springer, pp 407–421
Singhal B, Lalkaka J, Sankhla C (2003) Epidemiology and treatment of Parkinson’s disease in India. Parkinsonism Relat Disord 9:105–109
Skodda S, Flasskamp A, Schlegel U (2010) Instability of syllable repetition as a model for impaired motor processing: is Parkinson’s disease a “rhythm disorder”? J Neural Transm 117(5):605–612
Soares NM, Pereira GM, Altmann V, de Almeida RMM, Rieder CR (2019) Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson’s disease: a systematic review. J Neural Transm 126(3):219–232
Soubra R, Diab MO, Moslem B (2016) Identification of Parkinson’s disease by using multichannel vertical ground reaction force signals. In: 2016 International conference on bio-engineering for smart technologies (BioSMART). IEEE, pp 1–4
Su M, Chuang KS (2015) Dynamic feature selection for detecting Parkinson’s disease through voice signal. In: 2015 IEEE MTT-S 2015 international microwave workshop series on RF and wireless technologies for biomedical and healthcare applications (IMWS-BIO). IEEE, pp 148–149
Summa S, Tosi J, Taffoni F, Di Biase L, Marano M, Rizzo AC, Tombini M, Di Pino G, Formica D (2017) Assessing bradykinesia in parkinson’s disease using gyroscope signals. In: 2017 international conference on rehabilitation robotics (ICORR). IEEE, pp 1556–1561
Svehlık M, Zwick EB, Steinwender G, Linhart WE, Schwingenschuh P, Katschnig P, Ott E, Enzinger C (2009) Gait analysis in patients with Parkinson’s disease off dopaminergic therapy. Arch Phys Med Rehab 90(11):1880–1886
Sztah´o D, Kiss G, Vicsi K (2015) Estimating the severity of Parkinson’s disease from speech using linear regression and database partitioning. In: Sixteenth annual conference of the international speech communication association
Tagaris A, Kollias D, Stafylopatis A, Tagaris G, Kollias S (2018) Machine learning for neurodegenerative disorder diagnosis—survey of practices and launch of benchmark dataset. Int J Artif Intell Tools 27(03):1850011
Taleb C, Khachab M, Mokbel C, Likforman-Sulem L (2017) Feature selection for an improved Parkinson’s disease identification based on handwriting. In: 2017 1st international workshop on arabic script analysis and recognition (ASAR). IEEE, pp 52–56
Taleb C, Khachab M, Mokbel C, Likforman-Sulem L (2018) A reliable method to predict Parkinson’s disease stage and progression based on handwriting and re-sampling approaches. In: 2018 IEEE 2nd international workshop on arabic and derived script analysis and recognition (ASAR). IEEE, pp 7–12
Taleb C, Khachab M, Mokbel C, Likforman-Sulem L (2019) Visual representation of online handwriting time series for deep learning Parkinson’s disease detection. In: 2019 international conference on document analysis and recognition workshops (ICDARW). IEEE, vol 6, pp 25–30
Taleb C, Likforman-Sulem L, Mokbel C (2019) Improving deep learning Parkinson’s disease detection through data augmentation training. In: Mediterranean conference on pattern recognition and artificial intelligence. Springer, pp 79–93
Tang J, Yang B, Adams MP, Shenkov NN, Klyuzhin IS, Fotouhi S, Davoodi-Bojd E, Lu L, Soltanian-Zadeh H, Sossi V et al (2019) Artificial neural network–based prediction of outcome in Parkinson’s disease patients using datscan spect imaging features. Mol Imag Biol 21(6):1165–1173
Teipel SJ, Wegrzyn M, Meindl T, Frisoni G, Bokde AL, Fellgiebel A, Filippi M, Hampel H, Kloppel S, Hauenstein K et al (2012) Anatomical MRI and DTI in the diagnosis of Alzheimer’s disease: a european multicenter study. J Alzheimer’s Dis 31(3):S33–S47
Tiwari AK (2016) Machine learning based approaches for prediction of Parkinson’s disease. Mach Learn Appl 3(2):33–39
Torvi VG, Bhattacharya A, Chakraborty S (2018) Deep domain adaptation to predict freezing of gait in patients with parkinson’s disease. In: 2018 17th IEEE international conference on machine learning and applications (ICMLA). IEEE, pp 1001–1006
Tsanas A, Little MA, Fox C, Ramig LO (2013) Objective automatic assessment of rehabilitative speech treatment in Parkinson’s disease. IEEE Trans Neural Syst Rehabil Eng 22(1):181–190
Tsanas A, Little MA, McSharry PE, Ramig LO (2012) Using the cellular mobile telephone network to remotely monitor Parkinsons disease symptom severity. IEEE Trans Biomed Eng 9:458
Tsanas A, Little MA, McSharry PE, Spielman J, Ramig LO (2012) Novel speech signal processing algorithms for high-accuracy classification of parkinson’s disease. IEEE Trans Biomed Eng 59(5):1264–1271
Tsoulos I, Mitsi G, Stavrakoudis A, Papapetropoulos M et al (2019) Application of machine learning in a Parkinson’s disease digital biomarker dataset using neural network construction (NNC) methodology discriminates patient motor status. Front ICT 6:10
Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Yoneyama N, Hara K, Nakamura R, Watanabe H, Senda J, Atsuta N et al (2015) Distinct phenotypes of speech and voice disorders in Parkinson’s disease after subthalamic nucleus deep brain stimulation. J Neurol Neurosurg Psychiatry 86(8):856–864
Tuncer T, Dogan S, Acharya UR (2020) Automated detection of parkinson’s disease using minimum average maximum tree and singular value decomposition method with vowels. Biocybern Biomed Eng 40(1):211–220
Vaiciukynas E, Verikas A, Gelzinis A, Bacauskiene M (2017) Detecting Parkinson’s disease from sustained phonation and speech signals. PLoS ONE 12(10):859
Van Gemmert A, Adler CH, Stelmach G (2003) Parkinson’s disease patients undershoot target size in handwriting and similar tasks. J Neurol Neurosurg Psychiatry 74(11):1502–1508
Vasquez-Correa JC, Arias-Vergara T, Orozco-Arroyave JR, Vargas-Bonilla JF, Arias-Londono JD, Noth E (2015) Automatic detection of Parkinson’s disease from continuous speech recorded in non-controlled noise conditions. In: Sixteenth annual conference of the international speech communication association
Vasquez Correa JC, Orozco Arroyave JR, Arias-Londono JD, Vargas Bonilla JF, Noth E (2014) New computer aided device for real time analysis of speech of people with parkinson’s disease. Rev Fac Ingen Univ Antioq 72:87–103
Wan S, Liang Y, Zhang Y, Guizani M (2018) Deep multi-layer perceptron classifier for behavior analysis to estimate Parkinson’s disease severity using smartphones. IEEE Access 6:36825–36833
Wingate J, Kollia I, Bidaut L, Kollias S (2019) A unified deep learning approach for prediction of Parkinson’s disease. arXiv preprint arXiv:1911.10653
Wu K, Zhang D, Lu G, Guo Z (2018) Learning acoustic features to detect Parkinson’s disease. Neurocomputing 318:102–108
Xia Y, Zhang J, Ye Q, Cheng N, Lu Y, Zhang D (2018) Evaluation of deep convolutional neural networks for detection of freezing of gait in Parkinson’s disease patients. Biomed Signal Process Control 46:221–230
Yassir E, Ghizlane K, Mostafa M, Driss C (2019) Towards an automatic and early detection of parkinson’s disease: modeling of a polar coordinates system based on spiral tests. In: AIP conference proceedings. AIP Publishing LLC, vol 2074, p 020011
Zago M, Sforza C, Pacifici I, Cimolin V, Camerota F, Celletti C, Condoluci C, De Pandis MF, Galli M (2018) Gait evaluation using inertial measurement units in subjects with Parkinson’s disease. J Electromyogr Kinesiol 42:44–48
Zahid L, Maqsood M, Durrani MY, Bakhtyar M, Baber J, Jamal H, Mehmood I, Song OY (2020) A spectrogram-based deep feature assisted computer-aided diagnostic system for Parkinson’s disease. IEEE Access 8:35482–35495
Zeng W, Liu F, Wang Q, Wang Y, Ma L, Zhang Y (2016) Parkinson’s disease classification using gait analysis via deterministic learning. Neurosci Lett 633:268–278
Zham P, Kumar DK, Dabnichki P, Poosapadi Arjunan S, Raghav S (2017) Distinguishing different stages of Parkinson’s disease using composite index of speed and pen-pressure of sketching a spiral. Front Neurol 8:435
Zhan A, Little MA, Harris DA, Abiola SO, Dorsey E, Saria S, Terzis A (2016) High frequency remote monitoring of Parkinson’s disease via smartphone: platform overview and medication response detection. arXiv preprint arXiv:1601.00960
Zhao A, Qi L, Li J, Dong J, Yu H (2018) A hybrid spatio-temporal model for detection and severity rating of Parkinson’s disease from gait data. Neurocomputing 315:1–8
Zhuang X, Walsh RR, Sreenivasan K, Yang Z, Mishra V, Cordes D (2018) Incorporating spatial constraint in co-activation pattern analysis to explore the dynamics of resting-state networks: an application to Parkinson’s disease. Neuroimage 172:64–84
Ziegler M (2019) The impact of fall prevention education for individuals with Parkinson’s disease
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
Author declares no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Ayaz, Z., Naz, S., Khan, N.H. et al. Automated methods for diagnosis of Parkinson’s disease and predicting severity level. Neural Comput & Applic 35, 14499–14534 (2023). https://doi.org/10.1007/s00521-021-06626-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00521-021-06626-y