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A hub gene in an HIV-1 gene regulatory network is a promising target for anti-HIV-1 drugs

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Abstract

The existing anti-HIV-1 drugs have troublesome problems with side-effects and the development of drug resistance, etc. To avoid these problems by using our knowledge of complex network analyses, this study examines the topological conditions needed for a satisfactory anti-HIV-1 drug target, and suggests that a promising anti-HIV-1 drug target should be endowed with the features of a “hub” and a “bottleneck” in the HIV-1 proteins-intracellular agent interaction network.

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Author information

Authors and Affiliations

  1. Department of Knowledge-Based Information Engineering, Toyohashi University of Technology, 1-1 Tempaku, Toyohashi, Aichi, 441-8585, Japan

    Kouji Harada & Yoshiteru Ishida

Authors
  1. Kouji Harada
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  2. Yoshiteru Ishida
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Corresponding author

Correspondence to Kouji Harada.

Additional information

This work was presented in part at the 14th International Symposium on Artificial Life and Robotics, Oita, Japan, February 5–7, 2009

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Harada, K., Ishida, Y. A hub gene in an HIV-1 gene regulatory network is a promising target for anti-HIV-1 drugs. Artif Life Robotics 14, 528–531 (2009). https://doi.org/10.1007/s10015-009-0735-5

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  • DOI: https://doi.org/10.1007/s10015-009-0735-5

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