Skip to main content

Advertisement

Springer Nature Link
Log in

A time-dependent threshold condition to determine the onset of AIDS

  • Original Article
  • Published:
Artificial Life and Robotics Aims and scope Submit manuscript

Abstract

This study first considers the effects of “uninfectious” HIV-1 due to fatal mutations, and then analysis reveals that AIDS develops when the number of HIV-1 strains, i.e., antigenic diversity, is above a “time-dependent” threshold. This result is interesting because it suggests the possibility that the onset of AIDS could be dynamically determined. This dynamic behavior of the threshold may make the prediction of AIDS development difficult.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Explore related subjects

Discover the latest articles, news and stories from top researchers in related subjects.

References

  1. Green WC, Peterlin BM (2008) Molecular biology of HIV: implications for new therapies. In: Volberding PA, Sande MA, Warner C, et al (eds) Global HIV/AIDS medicine. Elsevier, Pennsylvania, pp 23–38

    Chapter  Google Scholar 

  2. Preston BD, Poiesz BJ, Loeb LA (1988) Fidelity of HIV-1 reverse transcriptase. Science 242(4882):1168–1171

    Article  Google Scholar 

  3. de Mercoyrol L, Job C, Job D (1989) Studies on the inhibition by alpha-amanitin of single-step addition reactions and productive RNA synthesis catalysed by wheat-germ RNA polymerase II. Biochem J 258(1):165–169

    Google Scholar 

  4. Domingo E (2000) Viruses at the edge of adaptation. Virology 270:251–253

    Article  Google Scholar 

  5. Holland JJ, Domingo E (1998) Origin and evolution of viruses. Virus genes 16:13–21

    Article  Google Scholar 

  6. Nowak MA, May RM (1991) Mathematical biology of HIV infections: antigenic variation and diversity threshold. Math Biosci 106:1–21

    Article  MATH  Google Scholar 

  7. Nowak MA, May RM (2000) Virus dynamics. Oxford University Press, Oxford

    MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Knowledged-Based Information Engineering, Toyohashi University of Technology, 1-1 Tempaku, Toyohashi, Aichi, 441-8585, Japan

    Kouji Harada & Yoshiteru Ishida

Authors
  1. Kouji Harada
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. Yoshiteru Ishida
    View author publications

    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence to Kouji Harada.

Additional information

This work was presented in part at the 14th International Symposium on Artificial Life and Robotics, Oita, Japan, February 5–7, 2009

About this article

Cite this article

Harada, K., Ishida, Y. A time-dependent threshold condition to determine the onset of AIDS. Artif Life Robotics 14, 532–534 (2009). https://doi.org/10.1007/s10015-009-0737-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10015-009-0737-3

Key words