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The Keratectasia Volume (KEV) in Corneal Topography to Evaluate the Effect of Corneal Collagen Cross-linking in Pediatric Keratoconus

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Abstract

The study aimed to evaluate the keratectasia volume (KEV) before and after corneal cross-linking (CXL) in pediatric patients. This study included 40 eyes of 25 pediatric patients (10–19 years) undergoing standard CXL. The support vector machine (SVM) algorithm was applied to transform mass pixels in corneal topography into a three-dimensioned model to calculate the KEV. The KEV, Kmax, K1, K2, Kave, keratectasia area (KEA), and thinnest corneal thickness (TCT) were determined before CXL and at 3, 6, and 12 months after surgery. The correlation between KEV and other parameters (Kmax, TCT, max decentration, eccentricity, and so on) was calculated. The KEV was 4.75 ± 0.74 preoperatively and 4.43 ± 1.22 postoperatively at last follow-up (p < 0.002). There was strong positive correlation between the KEV and Kmax (r = 0.806, p < 0.0005). The preoperat ive KEV was 4.32 ± 0.69 in mild to moderate keratoconus (Kmax < 58D) and 5.27 ± 0.37 in advanced keratoconus (Kmax > 58D) (p < 0.0005, t-test). Postoperative KEV and K readings remained stable at the early stage, and the KEV showed a more drastic decreasing trend than Kmax at sixth month. Statistical significance was found in the KEV between preoperative and 6 months after surgery (p < 0.0005), but not in Kmax and other parameters. In 83.3% (15 eyes out of 18 eyes) of the eyes, the preoperative KEV was greater than 4.6 in patients with significant flattening after CXL. Compared with K readings, the KEV can be regarded as a more sensitive index to evaluate the postoperative morphological changes after CXL in pediatric patients.

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Funding

This work was supported by Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, China.

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Authors and Affiliations

  1. Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China

    Xiangjun Wang, Zhiwei Li, Mengyao Li, Jia Wang & Guoying Mu

  2. School of Mathematics, Shandong University, Jinan, China

    Bo Zhang

  3. Liaocheng Aier Eye Hospital, Aier Eye Hospital Group, Liaocheng, China

    Jia Wang

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  1. Xiangjun Wang
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Correspondence to Guoying Mu.

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Wang, X., Zhang, B., Li, Z. et al. The Keratectasia Volume (KEV) in Corneal Topography to Evaluate the Effect of Corneal Collagen Cross-linking in Pediatric Keratoconus. J Digit Imaging 36, 1752–1759 (2023). https://doi.org/10.1007/s10278-021-00515-5

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