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Cognitive reserve and its implications for rehabilitation and Alzheimer’s disease

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Abstract

According to the Cognitive reserve hypothesis, several factors related to mental engagement, such as level of education, type of occupation, leisure activities and social network, appear to affect the risk of developing clinical dementia. The present article provides an overview of the studies that have investigated the effects of mental engagement and cognitive stimulation specifically on dementia of the Alzheimer’s type (AD). Mental training and cognitive stimulation interventions in AD have been shown to be useful in increasing patients’ ability in performing activities of daily living (ADL), allowing them to maintain relative independence. Since cognitive engagement and stimulation are known to modify the brain processes to perform tasks, by recruiting alternative and more efficient networks, this review is especially focused on cognitive rehabilitation in AD patients, which has been shown to improve their global functioning and cognition. This perspective stresses the idea that cognitive reserve is not a fixed factor, but can be continuously modified by life experiences, even when the brain is already affected by neuropathology.

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References

  • Adam S, Van der Linden M, Juillerat A-C, Salmon E (2010) The cognitive management of daily life activities in patients with mild to moderate Alzheimer’s disease in day care centre: a case report. Neuropsychol Rehabil 10:485–509

    Google Scholar 

  • Aldridge D (1995) Music therapy and the treatment of Alzheimer’s disease. Clin Gerontol 16(1):41–57

    Google Scholar 

  • Anderson J, Arens K, Johnson R, Coppens P (2001) Spaced retrieval vs. memory tape therapy in memory rehabilitation for dementia of the Alzheimer’s type. Clin Gerontol 24(1):123–140

    Google Scholar 

  • Anttila T, Helkala EL, Kivipelto M, Hallikainen M, Alhainen K, Heinonen H, Mannermaa A, Tuomilehto J, Soininen H, Nissinen A (2002) Midlife income, occupation, APOE status, and dementia: a population-based study. Neurology 59(6):887–893

    PubMed  CAS  Google Scholar 

  • Arkin SM (1992) Audio-assisted memory training with early Alzheimer’s patients: two single subject experiments. Clin Gerontol 12(2):77–96

    Google Scholar 

  • Arkin SM (1999) Elder rehab: a student-supervised exercise program for Alzheimer’s patients. The Gerontologist 39(6):729–735

    PubMed  CAS  Google Scholar 

  • Arkin SM (2000) Alzheimer memory training: students replicate learning successes. Am J Alzheimers Dis Other Demen 15(3):152–162

    Google Scholar 

  • Arkin S (2007) Language-enriched exercise plus socialization slows cognitive decline in Alzheimer’s disease. Am J Alzheimers Dis Other Demen 22(1):62–77

    PubMed  Google Scholar 

  • Au R, Albert ML, Obler LK (1988) The relationship of aphasia to dementia. Aphasiology 2:161–173

    Google Scholar 

  • Bäckman L, Josephsson S, Herlitz A, Stigsdotter A, Viitanen M (1991) The generalizability of training gains in dementia: effects of an imagery-based mnemonic on face-name retention duration. Psychol Aging 6(3):489–492

    PubMed  Google Scholar 

  • Barnett S, Ceci S (2002) When and where do we apply what we learn? A taxonomy for Far transfer. Psychol Bull 128:612–637

    PubMed  Google Scholar 

  • Beard CM, Kokmen E, Offord P, Kurland LT (1992) Lack of association between Alzheimer’s disease and education, occupation, marital status, or living arrangement. Neurology 42(11):2063

    PubMed  CAS  Google Scholar 

  • Beatty WW, Zavadil KD, Bailly RC, Rixen GJ, Farnham N, Fisher L (1988) Preserved musical skill in a severely demented patient. Int J Clin Neuropsychol 10:158–164

    Google Scholar 

  • Beatty WW, Winn P, Adams RL, Allen EW, Wilson DA, Prince JR, Olson KA, Dean K, Littleford D (1994) Preserved cognitive skills in dementia of the Alzheimer type. Arch Neurol 51:1040–1046

    PubMed  CAS  Google Scholar 

  • Bird M, Kinsella G (1996) Long-term cued recall of tasks in senile dementia. Psychol Aging 11(1):45–56

    PubMed  CAS  Google Scholar 

  • Borroni B, Alberici A, Agosti C, Premi E, Padovani A (2008) Education plays a different role in Frontotemporal Dementia and Alzheimer’s disease. Int J Geriatr Psychiatry 23(8):796–800

    PubMed  Google Scholar 

  • Bourgeois MS (1990) Enhancing conversation skills in patients with Alzheimer’s disease using a prosthetic memory aid. J Appl Behav Anal 23(1):29–42

    PubMed  CAS  Google Scholar 

  • Bourgeois MS (1992) Evaluating memory wallets in conversations with persons with dementia. J Speech Hear Disord 35(6):1344–1357

    CAS  Google Scholar 

  • Broe GA, Henderson AS, Creasey H et al (1990) A case–control study of Alzheimer’s disease in Australia. Neurology 40:1698–1707

    PubMed  CAS  Google Scholar 

  • Cahn-Weiner DA, Malloy PF, Rebok GW, Ott BR (2003) Results of a randomized placebo-controlled study of memory training for mildly impaired Alzheimer’s disease patients. Appl Neuropsychol 10(4):215–223

    PubMed  Google Scholar 

  • Camp CJ, Foss JW, O’Hanlon AM, Stevens AB (1996) Memory interventions for persons with dementia. Appl Cogn Psychol 10(3):193–210

    Google Scholar 

  • Chandra V, Ganguli M, Pandav R, Johnston J, Belle S, DeKosky ST (1998) Prevalence of Alzheimer’s disease and other dementias in rural India: the Indo-US study. Neurology 51(4):1000–1008

    PubMed  CAS  Google Scholar 

  • Cipriani G, Bianchetti A, Trabucchi M (2006) Outcomes of a computer-based cognitive rehabilitation program on Alzheimer’s disease patients compared with those on patients affected by mild cognitive impairment. Arch Gerontol Geriatr 43(3):327–335

    PubMed  Google Scholar 

  • Clare L, Woods RT (2004) Cognitive training and cognitive rehabilitation for people with early-stage Alzheimer’s disease: a review. Neuropsychol Rehabil 14(4):385–401

    Google Scholar 

  • Clare L, Wilson BA, Breen K, Hodges JR (1999) Errorless learning of face-name associations in early Alzheimer’s disease. Neurocase 5(1):37–46

    Google Scholar 

  • Clare L, Wilson BA, Carter G, Breen K, Gosses A, Hodges JR (2000) Intervening with everyday memory problems in dementia of Alzheimer type: an errorless learning approach. J Clin Exp Neuropsychol 22(1):132–146

    PubMed  CAS  Google Scholar 

  • Clare L, Wilson BA, Carter G, Hodges JR, Adams M (2001) Long-term maintenance of treatment gains following a cognitive rehabilitation intervention in early dementia of Alzheimer type: a single case study. Neuropsychol Rehabil 11(3):477–494

    Google Scholar 

  • Clare L, Wilson BA, Carter G, Roth I, Hodges JR (2002) Relearning face-name associations in early Alzheimer’s disease. Neuropsychology 16(4):538–547

    PubMed  Google Scholar 

  • Clare L, Wilson BA, Carter G, Hodges JR (2003) Cognitive rehabilitation as a component of early intervention in Alzheimer’s disease: a single case study. Aging Ment Health 7(1):15–21

    PubMed  CAS  Google Scholar 

  • Clare L, Wilson BA, Carter G, Roth I, Hodges JR (2004) Awareness in early-stage Alzheimer’s disease: relationship to outcome of cognitive rehabilitation. J Clin Exp Neuropsychol 26(2):215–226

    PubMed  Google Scholar 

  • Clare L, Linden D, Woods R, Whitaker R, Evans S, Parkinson C, van Paasschen J, Nelis S, Hoare Z, Yuen K, Rugg M (2010) Goal-oriented cognitive rehabilitation for people with early-stage alzheimer disease: a single-blind randomized controlled trial of clinical efficacy. Am J Geriatr Psychiatry 18:928–939

    PubMed  Google Scholar 

  • Cobb JL, Wolf PA, Au R, White R (1995) The effect of education on the incidence of dementia and Alzheimer’s disease in the Framingham study. Neurology 45(9):1707–1712

    PubMed  CAS  Google Scholar 

  • Crowe M, Andel R, Pedersen NL, Johansson B, Gatz M (2003) Does participation in leisure activities lead to reduced risk of Alzheimer’s disease? A prospective study of Swedish twins. J Gerontol B-Psychol 58(5):P249–P255

    Google Scholar 

  • Cuddy LL, Duffin JM (2005) Music, memory, and Alzheimer’s disease: is music recognition spared in dementia, and how can it be assessed? Med Hypotheses 64:229–235

    PubMed  Google Scholar 

  • Cummings JL (2004) Alzheimer’s disease. N Engl J Med 351:56–67

    PubMed  CAS  Google Scholar 

  • De Ronchi D, Fratiglioni L, Rucci P, Paternicò A, Graziani S, Dalmonte E (1998) The effect of education on dementia occurrence in an Italian population with middle to high socioeconomic status. Neurology 50(5):1231–1238

    PubMed  Google Scholar 

  • De Vreese LP, Neri M, Fioravanti M, Belloi L, Zanetti O (2001) Memory rehabilitation in Alzheimer’s disease: a review of progress. Int J Geriatr Psychiatry 16:794–809

    PubMed  Google Scholar 

  • Deweer B, Ergis AM, Fossati P, Pillon B (1994) Explicit memory, procedural learning and lexical priming in Alzheimer’s disease. Cortex 30(1):113–126

    PubMed  CAS  Google Scholar 

  • Di Carlo A, Baldereschi M, Amaducci LA et al (2002) Incidence of dementia, Alzheimer’s disease, and vascular dementia in Italy. The ILSA study. J Am Geriatr Soc 50:41–48

    PubMed  Google Scholar 

  • Diamond M (1993) An optimistic view of the aging brain. Generations 17:31–33

    Google Scholar 

  • Evans DA, Hebert LE, Beckett LA, Scherr PA, Albert MS, Chown MJ, Pilgrim DM, Taylor JO (1997) Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons. Arch Neurol 54(11):1399–1405

    PubMed  CAS  Google Scholar 

  • Fabrigoule C, Letenneur L, JFo Dartigues, Zarrouk M (1995) Social and leisure activities and risk of dementia: a prospective longitudinal study. J Am Geriatr Soc 43(5):485–490

    PubMed  CAS  Google Scholar 

  • Farina E, Fioravanti R, Chiavari L, Imbornone E, Alberoni M, Pomati S, Pinardi G, Pegnatti R, Mariani C (2002) Comparing two programs of cognitive training in Alzheimer’s disease: a pilot study. Acta Neurol Scand 105(5):365–371

    PubMed  Google Scholar 

  • Fornazzari L, Castle T, Nadkarni S, Ambrose M, Miranda D, Apanasiewicz N et al (2006) Preservation for episodic musical memory in a pianist with Alzheimer disease. Neurology 66:610–611

    PubMed  CAS  Google Scholar 

  • Fratiglioni L, Wang HX, Ericsson K, Maytan M, Winblad B (2000) Influence of social network on occurrence of dementia: a community-based longitudinal study. Lancet 355(9212):1315–1319

    PubMed  CAS  Google Scholar 

  • Friedland RP (1993) Epidemiology, education, and the ecology of Alzheimer’s disease. Neurology 43(2):246–249

    PubMed  CAS  Google Scholar 

  • Friedland RP, Fritsch T, Smyth KA, Koss E, Lerner AJ, Chen CH, Petot GJ, Debanne SM (2001) Patients with Alzheimer’s disease have reduced activities in midlife compared with healthy control-group members. Proc Natl Acad Sci USA 98(6):3440–3445

    PubMed  CAS  Google Scholar 

  • Fritsch T, McClendon MJ, Smyth KA, Lerner AJ, Chen CH, Petot GJ, Debanne SM, Soas A, Friedland RP (2001) Effects of educational attainment on the clinical expression of Alzheimer’s disease: results from a research registry. Am J Alzheimers Dis Other Demen 16(6):369–376

    PubMed  CAS  Google Scholar 

  • Gerber GJ, Prince PN, Snider HG, Atchison K, Dubois L, Kilgour JA (1991) Group activity and cognitive improvement among patients with Alzheimer’s disease. Hosp Community Psychiatry 42(8):843–845

    PubMed  CAS  Google Scholar 

  • Gilleard CJ (1997) Education and Alzheimer’s disease: a review of recent international epidemiological studies. Aging Ment Health 1(1):33–46

    Google Scholar 

  • Gotestam KG (1987) Learning versus environmental support for increasing reality orientation in senile demented patients. Eur J Psychiatry 1:7–12

    Google Scholar 

  • Grundman M, Ellis R, Olichney JM et al (1996) Importance of clinical features and marital status on survival in Alzheimer’s disease. Neurobiol Aging 17:S88–S89

    Google Scholar 

  • Håkanson K, Rovio S, Helkala E-L, Vilska A-R, Winblad B, Soininen H, Nissinen A, Mohammed AH, Kivipelto M (2009) Association between mid-life marital status and cognitive function in later life: population based cohort study. Br Med J 339(7712):1–12

    Google Scholar 

  • Hanley IG, Lusty K (1984) Case histories and shorter communications: memory aids in reality orientation: a single-case study. Behav Res Ther 22(6):709–712

    PubMed  CAS  Google Scholar 

  • Helmer C, Damon D, Letenneur L, Fabrigoule C, Barberger-Gateau P, Lafont S, Fuhrer R, Antonucci T, Commenges D, Orgogozo JM, Dartigues JF (1999) Marital status and risk of Alzheimer’s disease: a French population-based cohort study. Neurology 53(9):1953–1958

    PubMed  CAS  Google Scholar 

  • Heun R, Burkart M, Benkert O (1997a) Effect of repetition and inspection times on picture recall in patients with dementia of Alzheimer type. Dement Geriatr Cogn Disord 8(3):152–156

    PubMed  CAS  Google Scholar 

  • Heun R, Burkart M, Benkert O (1997b) Improvement of a picture recall by repetition in patients with dementia of Alzheimer type. Int J Geriatr Psychiatry 12(1):85–92

    PubMed  CAS  Google Scholar 

  • Hill LR, Klauber MR, Salmon DP, Yu ES (1993) Functional status, education, and the diagnosis of dementia in the Shanghai survey. Neurology 43(1):138–145

    PubMed  CAS  Google Scholar 

  • Hirono N, Mori E, Ikejiri Y, Imamura T, Shimomura T, Ikeda M, Yamashita H, Takatsuki Y, Tokimasa A, Yamadori A (1997) Procedural memory in patients with mild Alzheimer’s disease. Dement Geriatr Cogn Disord 8(4):210–216

    PubMed  CAS  Google Scholar 

  • Hofmann M, Hock C, Kühler A, Müller-Spahn F (1996) Interactive computer-based cognitive training in patients with Alzheimer’s disease. J Psychiatr Res 30(6):493–501

    PubMed  CAS  Google Scholar 

  • Hofmann M, Rösler A, Schwarz W, Müller-Spahn F, Krauchi K, Hock C, Seifritz E (2003) Interactive computer-training as a therapeutic tool in Alzheimer’s disease. Compr Psychiatry 44(3):213–219

    PubMed  Google Scholar 

  • Hultsch DF, Hertzog C, Small BJ, Dixon RA (1999) Use it or lose it: engaged lifestyle as a buffer of cognitive decline in aging? Psychol Aging 14(2):245–263

    PubMed  CAS  Google Scholar 

  • Jacobs DM, Sano M, Dooneief G, Marder K (1995) Neuropsychological detection and characterization of preclinical Alzheimer’s disease. Neurology 45(5):957–962

    PubMed  CAS  Google Scholar 

  • Karp A, Kareholt I, Qiu C, Bellander T, Winblad B, Fratiglioni L (2004) Relation of education and occupation-based socioeconomic status to incident Alzheimer’s disease. Am J Epidemiol 159(2):175–183

    PubMed  Google Scholar 

  • Katzman R (1993) Education and the prevalence of dementia and Alzheimer’s disease. Neurology 43(1):13–20

    PubMed  CAS  Google Scholar 

  • Katzman R, Brown T, Thal LJ, Fuld PA, Aronson M, Butters N, Klauber MR, Wiederholt W, Pay M, Xiong RB (1988) Comparison of rate of annual change of mental status score in four independent studies of patients with Alzheimer’s disease. Ann Neurol 24(3):384–389

    PubMed  CAS  Google Scholar 

  • Kawashima R, Okita K, Yamazaki R, Tajima N, Yoshida H, Taira M, Iwata K, Sasaki T, Maeyama K, Usui N, Sugimoto K (2005) Reading aloud and arithmetic calculation improve frontal function of people with dementia. J Gerontol A-Biol 60(3):380–384

    Google Scholar 

  • Kazui H, Mori E, Hashimoto M, Hirono N (2003) Enhancement of declarative memory by emotional arousal and visual memory function in Alzheimer’s disease. J Neuropsychiatry Clin Neurosci 15:221–226

    PubMed  Google Scholar 

  • Kesslak JP, Nackoul K, Sandman CA (1997) Memory training for individuals with Alzheimer’s disease improves name recall. Behav Neurol 10(4):137–142

    Google Scholar 

  • Koger SM, Chapin K, Brotons M (1999) Is music therapy an effective intervention for dementia? A meta-analytic review of the literature. J Music Ther 36:2–15

    PubMed  Google Scholar 

  • Kokmen E, Beard CM, O’Brien J, Kurland LT (1993) Educational attainment and Alzheimer’s disease: reassessment of the Rochester, Minnesota data (1975–1984). Neurology 43:A317

    Google Scholar 

  • Kondo K, Niino M, Shido K (1994) A case-control study of Alzheimer’s disease in Japan: significance of life-styles. Dementia 5(6):314–326

    PubMed  CAS  Google Scholar 

  • Letenneur L, Gilleron V, Commenges D, Helmer C, Orgogozo JM, Dartigues JF (1999) Are sex and educational level independent predictors of dementia and Alzheimer’s disease? Incidence data from the PAQUID project. J Neurol Neurosurg Psychiatry 66(2):177–183

    PubMed  CAS  Google Scholar 

  • Liao Y-C, Liu R-S, Teng EL, Lee Y-C, Wang P-N, Lin K-N, Chung C-P, Liu H-C (2005) Cognitive reserve: a SPECT study of 132 Alzheimer’s disease patients with an education range of 0–19 years. Dement Geriatr Cogn Disord 20(1):8–14

    PubMed  Google Scholar 

  • Lindsay J, Laurin D, Verreault R, Hébert R, Helliwell B, Hill GB, McDowell I (2002) Risk factors for Alzheimer’s disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol 156(5):445–453

    PubMed  Google Scholar 

  • Mahendra N, Arkin S (2003) Effects of four years of exercise, language, and social interventions on Alzheimer discourse. J Comm Disord 36(5):395–422

    Google Scholar 

  • McKitrick LA, Camp CJ (1993) Relearning the names of things: the spaced-retrieval intervention implemented by a caregiver. Clin Gerontol 14(2):60–62

    Google Scholar 

  • Miller E (1989) Language impairment in Alzheimer type dementia. Clin Psychol Rev 9(2):181–195

    Google Scholar 

  • Nielsen H, Lolk A, Andersen K, Andersen J, Kragh-Sørensen P (1999) Charateristics of elderly who develop Alzheimer’s disease during the next two years—a neuropsychological study using CAMCOG: the Odense Study. Int J Geriatr Psychiatry 14(11):957–963

    PubMed  CAS  Google Scholar 

  • Nijboer F, Hoffmann U, Morin F, Carmien S, Leon E, Koene R (2009) Affective brain-computer interfaces: psychophysiological markers of emotion in healthy people and people with amyotrophic lateral sclerosis. In: Workshop on affective brain-computer interfaces & IEEE international workshop on social signal processing ABCI 2009, 10–12 Sept 2009, Amsterdam, the Netherlands. Proceedings vol II, pp 1–11

  • Nithianantharajah J, Hannan A (2006) Enriched environments, experience-dependent plasticity and disorders of the nervous system. Nat Rev Neurosci 7:697–709

    PubMed  CAS  Google Scholar 

  • Ogunniyi A, Hall KS, Gureje O, Baiyewu O, Gao S, Unverzagt FW, Smith-Gamble V, Evans RE, Dickens J, Musick BS, Hendrie HC (2006) Risk factors for incident Alzheimer’s disease in African Americans and Yoruba. Metab Brain Dis 21(2–3):235–240

    PubMed  CAS  Google Scholar 

  • Ohnishi T, Matsuda H, Asada T, Aruga M, Hirakata M, Nishikawa M et al (2001) Functional anatomy of musical perception in musicians. Cereb Cortex 11:754–760

    PubMed  CAS  Google Scholar 

  • Olazarán J, Muñiz R, Reisberg B, Peña-Casanova J, del Ser T, Cruz-Jentoft AJ, Serrano P, Navarro E, Garcia de la Rocha ML, Frank A, Galiano M, Fernández-Bullido Y, Serra JA, Gonzáles-Salvador MT, Servilla C (2004) Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease. Neurology 63:2348–2353

    PubMed  Google Scholar 

  • Oriani M, Moniz-Cook E, Binetti G, Zanieri G, Frisoni GB, Geroldi C, De Vreese LP, Zanetti O (2003) An electronic memory aid to support prospective memory in patients in the early stages of Alzheimer’s disease: a pilot study. Aging Ment Health 7(1):22–27

    PubMed  CAS  Google Scholar 

  • Perneczky R, Drzezga A, Diehl-Schmid J, Schmid G, Wohlschläger A, Kars S, Grimmer T, Wagenpfeil S, Monsch A, Kurz A (2006) Schooling mediates brain reserve in Alzheimer’s disease: findings of fluoro-deoxy-glucose-positron emission tomography. J Neurol Neurosurg Psychiatry 77(9):1060–1063

    PubMed  CAS  Google Scholar 

  • Provencher Vr, Bier N, Trs Audet, Gagnon L (2008) Errorless-based techniques can improve route finding in early Alzheimer’s disease: a case study. Am J Alzheimers Dis Other Demen 23(1):47–56

    PubMed  Google Scholar 

  • Ptak R, Van der Linden M, Schnider A (2010) Cognitive rehabilitation of episodic memory disorders: from theory to practice. Front Hum Neurosci 4(57):1–11

    Google Scholar 

  • Qiu C, Bäckman L, Winblad B, Agüero-Torres H, Fratiglioni L (2001) The influence of education on clinically diagnosed dementia incidence and mortality data from the Kungsholmen Project. Arch Neurol 58(12):2034–2039

    PubMed  CAS  Google Scholar 

  • Qiu C, Karp A, von Strauss E, Winblad B, Fratiglioni L, Bellander T (2003) Lifetime principal occupation and risk of Alzheimer’s disease in the Kungsholmen project. Am J Ind Med 43(2):204–211

    PubMed  Google Scholar 

  • Quayhagen MP, Quayhagen M (1989) Differential effects of family-based strategies on Alzheimer’s disease. Gerontologist 29(2):150–155

    PubMed  CAS  Google Scholar 

  • Quayhagen MP, Quayhagen M (2001) Testing of cognitive stimulation intervention for dementia caregiving dyads. Neuropsychol Rehabil 11(3/4):319–332

    Google Scholar 

  • Quayhagen MP, Quayhagen M, Corbeil RR, Roth PA, Rodgers JA (1995) A dyadic remediation program for care recipients with dementia. Nurs Res 44:153–159

    Google Scholar 

  • Raggi A, Iannaccone S, Marcone A, Ginex V, Ortelli P, Nonis A, Giusti MC, Cappa SF (2007) The effects of a comprehensive rehabilitation program of Alzheimer’s disease in a hospital setting. Behav Neurol 18(1):1–6

    PubMed  Google Scholar 

  • Scarmeas N, Stern Y (2003) Cognitive reserve and lifestyle. J Clin Exp Neuropsychol 25(5):625–633

    PubMed  Google Scholar 

  • Scarmeas N, Levy G, Tang MX, Manly J, Stern Y (2001) Influence of leisure activity on the incidence of Alzheimer’s disease. Neurology 57(12):2236–2242

    PubMed  CAS  Google Scholar 

  • Schlaug G (2001) The brain of musicians. A model for functional and structural adaptation. Ann NY Acad Sci 930:281–299

    PubMed  CAS  Google Scholar 

  • Schreiber M, Lutz K, Schweizer A, Kalveram KT, Jäncke L (1998) Development and evaluation of an interactive computer-based training as a rehabilitation tool for dementia. Psychol Beitr 40(1):85–102

    Google Scholar 

  • Schreiber M, Schweizer A, Lutz K, Kalveram KT, Jäncke L (1999) Potential of an interactive computer-based training in the rehabilitation of dementia: an initial study. Neuropsychol Rehabil 9(2):155–167

    Google Scholar 

  • Seidler A, Bernhardt T, Nienhaus A, Frölich L (2003) Association between the psychosocial network and dementia—a case-control study. J Psychiat Res 37(2):89–98

    PubMed  Google Scholar 

  • Simmons-Stern NR, Budson AE, Ally BA (2010) Music as a memory enhancer in patients with Alzheimer’s disease. Neuropsychologia 48(10):3164–3167

    PubMed  Google Scholar 

  • Smith-Marchese K (1994) The effects of participatory music on the reality orientation and sociability of Alzheimer’s residents in a long-term care setting. Activ Adapt Aging 18(2):41–55

    Google Scholar 

  • Sobel BP (2001) Bingo vs. physical intervention in stimulating short-term cognition in Alzheimer’s disease patients. Am J Alzheimers Dis Other Demen 16(2):115–120

    PubMed  CAS  Google Scholar 

  • Spector A, Orrell M, Davies S, Woods B (2001) Can reality orientation be rehabilitated? Development and piloting of an evidence-based programme of cognition-based therapies for people with dementia. Neuropsychol Rehabil 11(3):377–397

    Google Scholar 

  • Stern Y (2002) What is cognitive reserve? Theory and reserve application of the reserve concept. J Int Neuropsychol Soc 8:448–460

    PubMed  Google Scholar 

  • Stern Y (2003) The concept of cognitive reserve: a catalyst for research. J Clin Exp Neuropsychol 25:589–593

    PubMed  Google Scholar 

  • Stern Y (2009) Cognitive reserve. Neuropsychologia 47(10):2015–2028

    PubMed  Google Scholar 

  • Stern Y, Alexander GE, Prohovnik I, Mayeux R (1992) Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer’s disease. Ann Neurol 32(3):371–375

    PubMed  CAS  Google Scholar 

  • Stern Y, Gurland B, Tatemichi TK, Tang MX (1994) Influence of education and occupation on the incidence of Alzheimer’s disease. JAMA 271(13):1004–1010

    PubMed  CAS  Google Scholar 

  • Tang MX, Cross P, Andrews H, Jacobs DM, Small S, Bell K, Merchant C, Lantigua R, Costa R, Stern Y, Mayeux R (2001) Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan. Neurology 56:49–56

    Google Scholar 

  • Teter B, Ashford W (2002) Neuroplasticity in Alzheimer’s disease. J Neurosci Res 70:402–437

    PubMed  CAS  Google Scholar 

  • The Canadian Study of Health and Aging (1994) Risk factors for Alzheimer’s disease in Canada. Neurology 44(11):2073–2080

    Google Scholar 

  • Thivierge S, Simard M, Jean L, Grandmaison É (2008) Errorless learning and spaced retrieval techniques to relearn instrumental activities of daily living in mild Alzheimer’s disease: a case report study. Neuropsychiatr Dis Treat 4(5):987–999

    PubMed  Google Scholar 

  • Thompson RG, Moulin CJA, Hayre S, Jones RW (2005) Music enhances category fluency in healthy older adults and Alzheimer’s disease patients. Exp Aging Res 31(1):91–99

    PubMed  CAS  Google Scholar 

  • Tsolaki M, Fountoulakis K, Chantzi E, Kazis A (1997) Risk factors for clinically diagnosed Alzheimer’s disease: a case-control study of a Greek population. Int Psychogeriatr 9(3):327–341

    PubMed  CAS  Google Scholar 

  • Van der Linden M, Juillerat A-C, Adam S (2003) Cognitive intervention. In: Mulligan R, Van der Linden M, Juillerat A-C (eds) The clinical management of early Alzheimer’s disease: a handbook. Lawrence Erlbaum Associates, Mahwah, NJ, pp 169–233

    Google Scholar 

  • Vance DE, Crowe M (2006) A proposed model of neuroplasticity and cognitive reserve in older adults. Activ Adapt Aging 30(3):61–79

    Google Scholar 

  • Vance DE, Roberson AJ, McGuinness TM, Fazeli PL (2010) How neuroplasticity and cognitive reserve protect cognitive functioning. J Psychosoc Nurs Ment Health Serv 48(4):23–30

    PubMed  Google Scholar 

  • Vanstone AD, Cuddy LL (2009) Musical memory in Alzheimer disease. Aging Neuropsychol Cogn 17(1):108–128

    Google Scholar 

  • Vanstone AD, Cuddy LL, Duffin JM, Alexander E (2009) Exceptional preservation of memory for tunes and lyrics. Ann NY Acad Sci 1169:291–294

    PubMed  Google Scholar 

  • Verghese J, Lipton RB, Katz MJ, Hall CB, Derby CA, Kuslansky G, Ambrose AF, Sliwinski M, Buschke H (2003) Leisure activities and the risk of dementia in the elderly. N Engl J Med 348(25):2508–2516

    PubMed  Google Scholar 

  • Wang H-X, Karp A, Winblad B, Fratiglioni L (2002) Late-life engagement in social and leisure activities is associated with a decreased risk of dementia: a longitudinal study from the Kungsholmen project. Am J Epidemiol 155(12):1081–1087

    PubMed  Google Scholar 

  • Whalley LJ, Deary IJ, Appleton CL, Starr JM (2004) Cognitive reserve and the neurobiology of cognitive aging. Ageing Res Rev 3:369–382

    PubMed  Google Scholar 

  • Wilson RS, Bennett DA, Gilley DW, Beckett LA, Barnes LL, Evans DA (2000) Premorbid reading activity and patterns of cognitive decline in Alzheimer disease. Arch Neurol 57(12):1718–1723

    PubMed  CAS  Google Scholar 

  • Wilson RS, Bennett DA, Bienias JL, Aggarwal NT, Mendes De Leon CF, Morris MC, Schneider JA, Evans DA (2002) Cognitive activity and incident AD in a population-based sample of older persons. Neurology 59(12):1910–1914

    PubMed  CAS  Google Scholar 

  • Zanetti O, Magni E, Binetti G, Bianchetti A (1994) Is procedural memory stimulation effective in Alzheimer’s disease? Int J Geriatr Psychiatry 9(12):1006–1007

    Google Scholar 

  • Zanetti O, Frisoni GB, De Leo D, Dello Buono M, Bianchetti A, Trabucchi M (1995) Reality orientation therapy in Alzheimer disease: useful or not? A controlled study. Alzheimer Dis Assoc Dis 9(3):132–138

    CAS  Google Scholar 

  • Zanetti O, Binetti G, Magni E, Rozzini L, Bianchetti A, Trabucchi M (1997) Procedural memory stimulation in Alzheimer’s disease: impact of a training programme. Acta Neurol Scand 95(3):152–157

    PubMed  CAS  Google Scholar 

  • Zanetti O, Zanieri G, Di Giovanni G, De Vreese LP, Pezzini A, Metitieri T, Trabucchi M (2001) Effectiveness of procedural memory stimulation in mild Alzheimer’s disease patients: a controlled study. Neuropsychol Rehabil 11(3):263–272

    Google Scholar 

  • Zarit SH, Zarit JM, Reever KE (1982) Memory training for severe memory loss: effects on senile dementia patients and their families. The Gerontologist 22(4):373–377

    PubMed  CAS  Google Scholar 

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Correspondence to Giulia Liberati.

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Liberati, G., Raffone, A. & Olivetti Belardinelli, M. Cognitive reserve and its implications for rehabilitation and Alzheimer’s disease. Cogn Process 13, 1–12 (2012). https://doi.org/10.1007/s10339-011-0410-3

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  • DOI: https://doi.org/10.1007/s10339-011-0410-3

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