Abstract
The fusion of multimodal medical images has garnered painstaking attention for clinical diagnosis and surgical planning. Although various scholars have designed numerous fusion methods, the challenges of extracting substantial features without introducing noise and non-uniform contrast hindered the overall quality of fused photos. This paper presents a multimodal medical image fusion (MMIF) using a novel deep convolutional neural network (D-CNN) along with preprocessing schemes to circumvent the mentioned issues. A non-linear average median filtering (NL-AMF) and multiscale improved top-hat (MI-TH) approach are utilized at the preprocessing stage to remove noise and improve the contrast of images. The non-linear anisotropic diffusion (NL-AD) scheme is employed to split the photos into base and detailed parts. The fusion of base parts is accomplished by a dimension reduction method to retain the energy information. In contrast, the detailed parts are fused by novel D-CNN to preserve the enriched detailed features effectively. The simulation results demonstrate that the proposed method produces better brightness contrast and more image details than existing methods by acquiring 0.7649 to 0.8986, 0.3520 to 0.4783, 0.7639 to 0.9056, 68.8932 to 81.0487 gain for quality transfer ratio from source photo to a generated photo (\(Q_{G}^{AB}\)), feature mutual information (FMI), structural similarity index (SSIM), and average pixel intensity (API) respectively.

















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Bhutto, J.A., Guosong, J., Rahman, Z. et al. Feature extraction of multimodal medical image fusion using novel deep learning and contrast enhancement method. Appl Intell 54, 5907–5930 (2024). https://doi.org/10.1007/s10489-024-05431-z
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DOI: https://doi.org/10.1007/s10489-024-05431-z