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Generalized seizures in a neural field model with bursting dynamics

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Abstract

The mechanisms underlying generalized seizures are explored with neural field theory. A corticothalamic neural field model that has accounted for multiple brain activity phenomena and states is used to explore changes leading to pathological seizure states. It is found that absence seizures arise from instabilities in the system and replicate experimental studies in numerous animal models and clinical studies.

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Acknowledgments

This work was supported by the Australian Research Council Center of Excellence for Integrative Brain Function (ARC Grant CE140100007) and by ARC Grant FL1401000225.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. School of Physics, The University of Sydney, Sydney, New South Wales, 2006, Australia

    X. Zhao & P. A. Robinson

  2. Center for Integrative Brain Function, University of Sydney, NSW, 2006, Australia

    X. Zhao & P. A. Robinson

  3. Neurosleep, 431 Glebe Point Rd, Glebe, New South Wales, 2037, Australia

    X. Zhao & P. A. Robinson

  4. Cooperative Research Center for Alertness, Safety, and Productivity, University of Sydney, NSW, 2006, Australia

    X. Zhao & P. A. Robinson

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Zhao, X., Robinson, P.A. Generalized seizures in a neural field model with bursting dynamics. J Comput Neurosci 39, 197–216 (2015). https://doi.org/10.1007/s10827-015-0571-7

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