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A mathematical model of recurrent spreading depolarizations

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Abstract

A detailed biophysical model for a neuron/astrocyte network is developed in order to explore mechanisms responsible for the initiation and propagation of recurrent cortical spreading depolarizations. The model incorporates biophysical processes not considered in the earlier models. This includes a model for the Na+-glutamate transporter, which allows for a detailed description of reverse glutamate uptake. In particular, we consider the specific roles of elevated extracellular glutamate and K+ in the initiation, propagation and recurrence of spreading depolarizations.

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Acknowledgments

This work was partially supported by the US National Science Foundation DMS Award 1410935. The first three authors all contributed equally to this work.

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Authors and Affiliations

  1. Department of Mathematics, Ohio State University, Columbus, OH, USA

    Cameron Conte, Ray Lee, Monica Sarkar & David Terman

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  1. Cameron Conte
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  2. Ray Lee
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  3. Monica Sarkar
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  4. David Terman
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Correspondence to David Terman.

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Conte, C., Lee, R., Sarkar, M. et al. A mathematical model of recurrent spreading depolarizations. J Comput Neurosci 44, 203–217 (2018). https://doi.org/10.1007/s10827-017-0675-3

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